Results 41 to 50 of about 1,235 (162)

Divergent Strategy for the Synthesis of α-Aryl-Substituted Fosmidomycin Analogues [PDF]

The Journal of Organic Chemistry, 2007
Fosmidomycin is the first representative of a new class of antimalarial drugs acting through inhibition of 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway for the synthesis of isoprenoids.
Devreux, Vincent, Wiesner, Jochen, Jomaa, Hassan, Rozenski, Jef, Van der Eycken, Johan, Van Calenbergh, Serge   +5 more
openaire   +3 more sources

Divergent Isoprenoid Biosynthesis Pathways in Staphylococcus Species Constitute a Drug Target for Treating Infections in Companion Animals

mSphere, 2016
Staphylococcus species are a leading cause of skin and soft tissue infections in humans and animals, and the antibiotics used to treat these infections are often the same.
Ana M. Misic, Christine L. Cain, Daniel O. Morris, Shelley C. Rankin, Daniel P. Beiting   +4 more
doaj   +1 more source

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2014
The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone.
Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch   +12 more
doaj   +1 more source

New Application of cycloSaligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria

Molecules, 2023
In this work, we implemented for the first time the cycloSaligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria.
Mathilde Munier, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard   +4 more
doaj   +1 more source

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

mBio, 2019
Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathways in Plasmodium falciparum central carbon metabolism. We show that the P.
Laure Dumont, Mark B. Richardson, Phillip van der Peet, Danushka S. Marapana, Tony Triglia, Matthew W. A. Dixon, Alan F. Cowman, Spencer J. Williams, Leann Tilley, Malcolm J. McConville, Simon A. Cobbold   +10 more
doaj   +1 more source

Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2009
Deliberate and natural outbreaks of infectious disease underscore the necessity of effective vaccines and antimicrobial/antiviral therapeutics. The prevalence of antibiotic resistant strains and the ease by which antibiotic resistant bacteria can be ...
Safdar Jawaid, Heather Seidle, Weidong Zhou, Hafsa Abdirahman, Maher Abadeer, Joseph H Hix, Monique L van Hoek, Robin D Couch   +7 more
doaj   +1 more source

DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Journal of Medicinal Chemistry, 2013
The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. The MEP pathway is used by a number of pathogens, including Mycobacterium tuberculosis and apicomplexan parasites, and differs ...
Jansson, Anna, Więckowska, Anna, Björkelid, Christofer, Yahiaoui, Samir, Sooriyaarachchi, Sanjeewani, Lindh, Martin, Bergfors, Terese, Dharavath, Shyamraj, Desroses, Matthieu, Suresh, Surisetti, Andaloussi, Mounir, Nikhil, Rautela, Sreevalli, Sharma, Srinivasa, Bachally R., Larhed, Mats, Jones, T. Alwyn, Karlén, Anders, Mowbray, Sherry L.   +17 more
openaire   +4 more sources

Fosmidomycin biosynthesis diverges from related phosphonate natural products [PDF]

Nature Chemical Biology, 2019
Fosmidomycin and related molecules comprise a family of phosphonate natural products with potent antibacterial, antimalarial and herbicidal activities. To understand the biosynthesis of these compounds, we characterized the fosmidomycin producer, Streptomyces lavendulae, using biochemical and genetic approaches.
Elizabeth I. Parkinson, Annette Erb, Andrew C. Eliot, Kou-San Ju, William W. Metcalf   +4 more
openaire   +2 more sources

Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway. [PDF]

PLoS ONE, 2013
Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid, termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely central to biosynthesis pathways, including generation of isoprenoids ...
Joana M Haussig, Kai Matuschewski, Taco W A Kooij   +2 more
doaj   +1 more source

Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents [PDF]

ACS Medicinal Chemistry Letters, 2018
Two classes of prodrugs of a fosmidomycin surrogate were synthesized and investigated for their ability to inhibit in vitro growth of P. falciparum and M. tuberculosis. To this end, a novel efficient synthesis route was developed involving a cross metathesis reaction as a key step.
Charlotte Courtens, Martijn Risseeuw, Guy Caljon, Paul Cos, Serge Van Calenbergh   +4 more
openaire   +3 more sources