Results 11 to 20 of about 1,235 (162)

Metabolic Labeling and Visualization of Isoprenoids Using Alkyne-Modified DMAPP Analogs in Bacillus subtilis. [PDF]

Angew Chem Int Ed Engl
Fluorescence‐based visualization and targeted mass–spectrometric enrichment of membrane‐embedded isoprenoids in Bacillus subtilis via cell‐permeant, alkynylated DMAPP analogs. ABSTRACT Isoprenoids are a chemically and functionally diverse class of metabolites that underlie essential bacterial physiology including respiration and cell envelope ...
Hulsey ZN, McBee DP, Dolan CL, Rossi FM, Truslow NA, Taylor AR, Trybala TN, Baccile JA.   +7 more
europepmc   +2 more sources

Fosmidomycin for the Treatment of Canine Otitis Externa: A Randomised, Double-Blinded, Controlled 'Split Body' Clinical Trial. [PDF]

Vet Dermatol
ABSTRACT Background Targeted antimicrobial therapy for canine otitis externa (OE) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non‐mevalonate pathway for isoprenoid biosynthesis utilised by canine‐adapted, and not human‐adapted, staphylococci.
Citron LE, Stefanovski D, You Y, Proctor R, Watson D, Randall J, Cain CL.   +6 more
europepmc   +2 more sources

Population pharmacokinetics of fosmidomycin and clindamycin in combination with artesunate for uncomplicated Plasmodium falciparum malaria in Gabonese children and adults [PDF]

Malaria Journal
Background The increasing prevalence of artemisinin resistance in Plasmodium falciparum malaria highlights the urgent need for new, effective treatment strategies.
Christoph Pfaffendorf, Jean Claude Dejon-Agobé, Jean Ronald Edoa, Oumou Maïga-Ascofaré, Ebenezer Ahenkan, Ayôla Akim Adegnika, Michael Ramharter, Sebastian G. Wicha, Johannes Mischlinger   +8 more
doaj   +2 more sources

In vitro activity of the antimalarial, antibiotic drugs fosmidomycin and clindamycin against clinical isolates of bacterial bloodstream infections in febrile, hospitalized Ghanaian children [PDF]

Malaria Journal
Background The clinical and laboratory distinction between malaria and bacterial blood stream infections in patients with undifferentiated fever remains challenging.
Christoph Pfaffendorf, Sebastian G. Wicha, Elina Petersen, Jürgen May, Miklas Martens, Charity Wiafe Akenten, Ghyslain Mombo-Ngoma, Peter G. Kremsner, Denise Dekker, Michael Ramharter, Johannes Mischlinger   +10 more
doaj   +2 more sources

Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Fosmidomycin and clindamycin target the Plasmodium apicoplast. Combination clinical trials have produced mixed results with the primary problem being the recrudescent infection frequency by day 28.
Leah A. Walker, Vision Bagonza, Bryce Bobb, David J. Sullivan   +3 more
doaj   +2 more sources

Expanding the Chemical Space of Reverse Fosmidomycin Analogs. [PDF]

ACS Med Chem Lett
Multidrug-resistant pathogens pose a major threat to human health, necessitating the identification of new drug targets and lead compounds that are not susceptible to cross-resistance. This study demonstrates that novel reverse thia analogs of the phosphonohydroxamic acid antibiotic fosmidomycin inhibit 1-deoxy-d-xylulose 5-phosphate reductoisomerase ...
Knak T, Takada S, Illarionov B, Krisilia V, Pessanha de Carvalho L, Lungerich B, Sakamoto Y, Höfmann S, Bacher A, Kalscheuer R, Held J, Fischer M, Tanaka N, Kurz T.   +13 more
europepmc   +3 more sources

A Chemical Probe for Increasing Leaf Tocopherol Levels by Coordinated Modulation of Biosynthesis, Competition and Storage. [PDF]

Plant Biotechnol J
ABSTRACT Plant biofortification with phytonutrients typically relies on metabolic engineering strategies known as ‘push’ (enhancing biosynthetic flux), ‘block’ (inhibiting competing pathways) and ‘pull’ (promoting metabolite storage). Here, we describe a novel synthetic compound, X57, that simultaneously targets biosynthesis, competition and storage to
Perez-Colao P, Glauser G, Cruces J, Lozano-Juste J, Rodriguez-Concepcion M.   +4 more
europepmc   +2 more sources

Development and application of an LC–MS/MS method for quantification of fosmidomycin in human and rat plasma [PDF]

Malaria Journal
Background Malaria still poses a significant burden on global health, with millions of cases reported annually and rising resistance to current treatments, emphasizing the need for new therapeutic strategies.
Christoph Pfaffendorf, Keanu D. Sackmann, Johannes Mischlinger, Jean Claude Dejon-Agobé, Oumou Maïga-Ascofaré, Ebenezer Ahenkan, Ayôla Akim Adegnika, Michael Ramharter, Philipp Uhl, Gert Fricker, Sebastian G. Wicha   +10 more
doaj   +2 more sources

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents [PDF]

Molecules
It is established that reverse hydroxamate analogs of fosmidomycin inhibit the growth of Plasmodium falciparum by inhibiting 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate pathway, which is absent in humans.
Sana Takada, Mona A. Abdullaziz, Stefan Höfmann, Talea Knak, Shin-ichiro Ozawa, Yasumitsu Sakamoto, Thomas Kurz, Nobutada Tanaka   +7 more
doaj   +2 more sources

Antibiotic fosmidomycin protects bacteria from cell wall perturbations by antagonizing oxidative damage-mediated cell lysis [PDF]

Frontiers in Microbiology
Cell wall peptidoglycan is a defining component of bacterial cells, and its biosynthesis is a major target for medically important antibiotics. Recent studies have revealed that antibiotics can kill cells not only by their direct effects on wall ...
Yoshikazu Kawai, Jeff Errington
doaj   +2 more sources