Dxr is essential in
BMC Microbiology, 2008 Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis.
Parish Tanya, Brown Amanda C
doaj +4 more sources
Isoprene Increases Thermotolerance of Fosmidomycin-Fed Leaves [PDF]
Plant Physiology, 2001 Abstract Isoprene is synthesized and emitted in large amounts by a number of plant species, especially oak (Quercus sp.) and aspen (Populussp.) trees. It has been suggested that isoprene improves thermotolerance by helping photosynthesis cope with high temperature.
Sharkey, Thomas D. +2 more
openaire +4 more sources
Frontiers in Microbiology, 2012 The methylerythritol phosphate (MEP) pathway is essential in most prokaryotes and some lower eukaryotes but absent from human cells, and is a validated target for antimicrobial drug development.
Ryan S Mackie +4 more
doaj +2 more sources
Divergent Strategy for the Synthesis of α-Aryl-Substituted Fosmidomycin Analogues [PDF]
The Journal of Organic Chemistry, 2007 Fosmidomycin is the first representative of a new class of antimalarial drugs acting through inhibition of 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway for the synthesis of isoprenoids.
Devreux, Vincent +5 more
openaire +5 more sources
Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2. [PDF]
PLoS ONE, 2014 Fosmidomycin is a time-dependent nanomolar inhibitor of methylerythritol phosphate (MEP) synthase, which is the enzyme that catalyzes the first committed step in the MEP pathway to isoprenoids.
David T Fox +11 more
doaj +3 more sources
DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
Journal of Medicinal Chemistry, 2013 The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. The MEP pathway is used by a number of pathogens, including Mycobacterium tuberculosis and apicomplexan parasites, and differs ...
Jansson, Anna +17 more
openaire +5 more sources
Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro [PDF]
Frontiers in Cell and Developmental Biology, 2020 Babesia microti, the main pathogen causing human babesiosis, has been reported to exhibit resistance to the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, suggesting the necessity of developing new drugs.
Sen Wang +24 more
doaj +3 more sources
Fosmidomycin as an Antimalarial Agent
, 2012 The isoprenoid biosynthesis of Plasmodium falciparum, the causative agent of malignant tertiana malaria, solely depends on the mevalonate-independent 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway [also known as the 1-deoxy-d-xylulose 5-phosphate (DXP) pathway]. The enzymes of the MEP pathway of P.
Jochen Wiesner +10 more
openaire +2 more sources
Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria [PDF]
Malaria Journal, 2008 Background This study investigated the pharmacokinetics of fosmidomycin when given in combination with clindamycin at two dosage regimens in patients with acute uncomplicated falciparum malaria.
Chauemung Anurak +5 more
doaj +2 more sources
α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues
Molecules, 2021 Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli.
Aurore Dreneau +7 more
doaj +2 more sources