Mutant-Based Model of Two Independent Pathways for Carotenoid-Mediated Chloroplast Biogenesis in Arabidopsis Embryos [PDF]
Frontiers in Plant Science, 2019 Chloroplasts are essential for autonomous plant growth, and their biogenesis is a complex process requiring both plastid and nuclear genome. One of the essential factors required for chloroplast biogenesis are carotenoids.
Eva Vranová +3 more
doaj +3 more sources
The organ-specific differential roles of rice DXS and DXR, the first two enzymes of the MEP pathway, in carotenoid metabolism in Oryza sativa leaves and seeds. [PDF]
BMC Plant Biol, 2020 Deoxyxylulose 5-phosphate synthase (DXS) and deoxyxylulose 5-phosphate reductoisomerase (DXR) are the enzymes that catalyze the first two enzyme steps of the methylerythritol 4-phosphate (MEP) pathway to supply the isoprene building-blocks of carotenoids.
You MK +6 more
europepmc +2 more sources
Combination of Entner-Doudoroff pathway with MEP increases isoprene production in engineered Escherichia coli. [PDF]
PLoS ONE, 2013 Embden-Meyerhof pathway (EMP) in tandem with 2-C-methyl-D-erythritol 4-phosphate pathway (MEP) is commonly used for isoprenoid biosynthesis in E. coli. However, this combination has limitations as EMP generates an imbalanced distribution of pyruvate and ...
Huaiwei Liu +7 more
doaj +5 more sources
Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb. [PDF]
BMC Plant Biol, 2019 Nothapodytes nimmoniana, a plant of pivotal medicinal significance is a source of potent anticancer monoterpene indole alkaloid (MIA) camptothecin (CPT). This compound owes its potency due to topoisomerase-I inhibitory activity. However, biosynthetic and
Rather GA +5 more
europepmc +2 more sources
Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2012 Isoprenoids, which are a large group of natural and chemical compounds with a variety of applications as e.g. fragrances, pharmaceuticals and potential biofuels, are produced via two different metabolic pathways, the mevalonate (MVA) pathway and the 2-C ...
Siavash Partow +4 more
doaj +4 more sources
Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants [PDF]
Journal of Experimental Botany, 2009 The methyl-D-erythritol 4-phosphate pathway is responsible for the biosynthesis of a substantial number of natural compounds of biological and biotechnological importance. In recent years, this pathway has become an obvious target to develop new herbicides and antimicrobial drugs.
Elizabeth, Cordoba +2 more
openaire +4 more sources
MEP pathway-mediated isopentenol production in metabolically engineered Escherichia coli [PDF]
Microbial Cell Factories, 2014 BackgroundIsopentenols, such as prenol and isoprenol, are promising advanced biofuels because of their higher energy densities and better combustion efficiencies compared with ethanol.
Huaiwei Liu +5 more
semanticscholar +3 more sources
Frontiers in Plant Science, 2016 Carotenoids and chlorophylls are photosynthetic pigments synthesized in plastids from metabolic precursors provided by the methylerythritol 4-phosphate (MEP) pathway.
Kevin Simpson +3 more
doaj +2 more sources
Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2. [PDF]
PLoS ONE, 2014 Fosmidomycin is a time-dependent nanomolar inhibitor of methylerythritol phosphate (MEP) synthase, which is the enzyme that catalyzes the first committed step in the MEP pathway to isoprenoids.
David T Fox +11 more
doaj +6 more sources
Catalysts, 2019 Microbial production is a promising method that can overcome major limitations in conventional methods of lycopene production, such as low yields and variations in product quality.
Min Jae Kim +4 more
semanticscholar +3 more sources