Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway. [PDF]
Front Microbiol, 2023 Terpenoids are a diverse class of compounds with wide-ranging uses including as industrial solvents, pharmaceuticals, and fragrances. Efforts to produce terpenoids sustainably by engineering microbes for fermentation are ongoing, but industrial production still largely relies on nonrenewable sources.
Marshall B +4 more
europepmc +4 more sources
Differential contribution of the first two enzymes of the MEP pathway to the supply of metabolic precursors for carotenoid and chlorophyll biosynthesis in carrot (Daucus carota) [PDF]
Frontiers in Plant Science, 2016 Carotenoids and chlorophylls are photosynthetic pigments synthesized in plastids from metabolic precursors provided by the methylerythritol 4-phosphate (MEP) pathway.
Kevin Simpson +3 more
doaj +2 more sources
The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. [PDF]
Parasit Vectors, 2018 Background The apicomplexan parasite Babesia orientalis, the causative agent of water buffalo babesiosis in China, is widespread in central and south China, resulting in a huge economic loss annually.
He L +8 more
europepmc +2 more sources
Catalysts, 2019 Microbial production is a promising method that can overcome major limitations in conventional methods of lycopene production, such as low yields and variations in product quality.
Myung Hyun Noh +2 more
exaly +2 more sources
Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway
Applied Microbiology and Biotechnology, 2011 Isoprene is an aviation fuel of high quality and an important polymer building block in the synthetic chemistry industry. In light of high oil prices, sustained availability, and environmental concerns, isoprene from renewable materials is contemplated ...
Yang, Jianming +13 more
core +3 more sources
PLoS ONE, 2013 In Catharanthus roseus, the monoterpene moiety exerts a strong flux control for monoterpene indole alkaloid (MIA) formation. Monoterpene synthesis depends on the methyl-D-erythritol 4-phosphate (MEP) pathway. Here, we have explored the regulation of this
Mei Han +6 more
doaj +2 more sources
Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway. [PDF]
Hortic Res, 2021 Abstract Sclareol, an antifungal specialized metabolite produced by clary sage, Salvia sclarea, is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide. Sclareol is mainly produced in clary sage flower calyces; however, the cellular localization of the sclareol biosynthesis remains unknown ...
Chalvin C +12 more
europepmc +6 more sources
Scientific Reports, 2021 Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia
Sivamoke Dissook +5 more
doaj +1 more source
Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. [PDF]
PLoS ONE, 2011 Deliberate and natural outbreaks of infectious disease, the prevalence of antibiotic resistant strains, and the ease by which antibiotic resistant bacteria can be intentionally engineered all underscore the necessity of effective vaccines and continued ...
Arthur Tsang +5 more
doaj +1 more source
Metabolic engineering of endogenous MEP pathway for enhanced lycopene production in <i>Escherichia coli</i>. [PDF]
Synth Syst BiotechnolMicrobial cell factories represent the primary approach for heterologous lycopene synthesis, where gene source selection and pathway regulation have been demonstrated to have a significant impact on lycopene titer. In this study, key lycopene biosynthesis genes (crtE, crtB and crtI) derived from the extremophile Deinococcus wulumuqiensis R12 were ...
Xu X +6 more
europepmc +3 more sources