Results 21 to 30 of about 15,771 (216)

Metabolic engineering of endogenous MEP pathway for enhanced lycopene production in <i>Escherichia coli</i>. [PDF]

Synth Syst Biotechnol
Microbial cell factories represent the primary approach for heterologous lycopene synthesis, where gene source selection and pathway regulation have been demonstrated to have a significant impact on lycopene titer. In this study, key lycopene biosynthesis genes (crtE, crtB and crtI) derived from the extremophile Deinococcus wulumuqiensis R12 were ...
Xu X, Xing H, Zhi H, Qin C, Deng Y, Wei W, Huang C.   +6 more
europepmc   +3 more sources

MEP Pathway: First-Synthesized IspH-Directed Prodrugs with Potent Antimycobacterial Activity. [PDF]

Microorganisms
We report the first synthesis of IspH-directed prodrugs targeting the terminal enzyme of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH or LytB). A series of alkyne and pyridine monophosphate cycloSaligenyl (cycloSal) prodrugs were prepared to enhance membrane permeability by masking ...
Allamand A, Noël-Duchesneau L, Ettelbruck C, De Luna E, Lièvremont D, Grosdemange-Billiard C.   +5 more
europepmc   +3 more sources

The MEP-pathway genes are polyphyletic origin and evolutionary conserved [PDF]

, 2020
Abstract BackgroundIsoprenoids are amongst the most ancient and essential class of metabolites produced in all organisms, either via mevalonate (MVA)-and/or methylerythritol dicyclophosphate (MEP)-pathways. The MEP-pathway is present in all plastid-bearing organisms and most eubacteria.
Liping Zeng, Katayoon Dehesh
openaire   +1 more source

Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots. [PDF]

PLoS ONE, 2012
Salvia miltiorrhiza has been widely used in the treatment of coronary heart disease. Tanshinones, a group of diterpenoids are the main active ingredients in S. miltiorrhiza.
Dongfeng Yang, Xuhong Du, Xiao Liang, Ruilian Han, Zongsuo Liang, Yan Liu, Fenghua Liu, Jianjun Zhao   +7 more
doaj   +1 more source

Production of Astaxanthin Using CBFD1/HFBD1 from Adonis aestivalis and the Isopentenol Utilization Pathway in Escherichia coli

Bioengineering, 2023
Astaxanthin is a powerful antioxidant and is used extensively as an animal feed additive and nutraceutical product. Here, we report the use of the β-carotene hydroxylase (CBFD1) and the β-carotene ketolase (HBFD1) from Adonis aestivalis, a flowering ...
Jared H. Roth, Valerie C. A. Ward
doaj   +1 more source

Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites. [PDF]

PLoS Pathog
A proposed treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, the parasitic source of farnesyl and geranylgeranyl pyrophosphate (FPP and GGPP, respectively). Both FPP and GGPP are crucial for the biosynthesis of several essential metabolites
Crispim M, Verdaguer IB, Hernández A, Kronenberger T, Fenollar À, Yamaguchi LF, Alberione MP, Ramirez M, de Oliveira SS, Katzin AM, Izquierdo L.   +10 more
europepmc   +5 more sources

The yield of essential oils in Melaleuca alternifolia (Myrtaceae) is regulated through transcript abundance of genes in the MEP pathway.

PLoS ONE, 2013
Medicinal tea tree (Melaleuca alternifolia) leaves contain large amounts of an essential oil, dominated by monoterpenes. Several enzymes of the chloroplastic methylerythritol phosphate (MEP) pathway are hypothesised to act as bottlenecks to the ...
Hamish Webb, Robert Lanfear, John Hamill, William J Foley, Carsten Külheim   +4 more
doaj   +1 more source

Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors. [PDF]

PLoS One, 2018
The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathways.
Sanders S, Bartee D, Harrison MJ, Phillips PD, Koppisch AT, Freel Meyers CL.   +5 more
europepmc   +5 more sources

Identification of target genes of the bZIP transcription factor OsTGAP1, whose overexpression causes elicitor-induced hyperaccumulation of diterpenoid phytoalexins in rice cells. [PDF]

PLoS ONE, 2014
Phytoalexins are specialised antimicrobial metabolites that are produced by plants in response to pathogen attack. Momilactones and phytocassanes are the major diterpenoid phytoalexins in rice and are synthesised from geranylgeranyl diphosphate, which is
Koji Miyamoto, Takashi Matsumoto, Atsushi Okada, Kohei Komiyama, Tetsuya Chujo, Hirofumi Yoshikawa, Hideaki Nojiri, Hisakazu Yamane, Kazunori Okada   +8 more
doaj   +1 more source

Mutant-Based Model of Two Independent Pathways for Carotenoid-Mediated Chloroplast Biogenesis in Arabidopsis Embryos

Frontiers in Plant Science, 2019
Chloroplasts are essential for autonomous plant growth, and their biogenesis is a complex process requiring both plastid and nuclear genome. One of the essential factors required for chloroplast biogenesis are carotenoids.
Eva Vranová, Diana Kopcsayová, Ján Košuth, Maite Colinas   +3 more
doaj   +1 more source