Results 1 to 10 of about 16,936 (186)

Synthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway [PDF]

Microbial Cell Factories, 2021
Background Cembranoids are one kind of diterpenoids with multiple biological activities. The tobacco cembratriene-ol (CBT-ol) and cembratriene-diol (CBT-diol) have high anti-insect and anti-fungal activities, which is attracting great attentions for ...
Yu Zhang, Shiquan Bian, Xiaofeng Liu, Ning Fang, Chunkai Wang, Yanhua Liu, Yongmei Du, Michael P. Timko, Zhongfeng Zhang, Hongbo Zhang   +9 more
doaj   +5 more sources

Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. [PDF]

PLoS ONE, 2012
The depleting petroleum reserve, increasingly severe energy crisis, and global climate change are reigniting enthusiasm for seeking sustainable technologies to replace petroleum as a source of fuel and chemicals.
Jianming Yang, Mo Xian, Sizheng Su, Guang Zhao, Qingjuan Nie, Xinglin Jiang, Yanning Zheng, Wei Liu   +7 more
doaj   +6 more sources

Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli [PDF]

Microbial Cell Factories, 2022
Background Lycopene is increasing in demand due to its widespread use in the pharmaceutical and food industries. Metabolic engineering and synthetic biology technologies have been widely used to overexpress the heterologous mevalonate pathway and ...
Tao Cheng, Lili Wang, Chao Sun, Congxia Xie   +3 more
doaj   +4 more sources

Cloning and expression analysis of mevalonate kinase and phosphomevalonate kinase genes associated with the MVA pathway in Santalum album. [PDF]

Sci Rep, 2021
Abstract Sandalwood ( Santalum album L.) is highly valued for its fragrant heartwood and extracted oil. Santalols, which are the main components of that oil, are terpenoids, and these are biosynthesized via the mevalonic acid (MVA) pathway.
Niu M, Xiong Y, Yan H, Zhang X, Li Y, da Silva JAT, Ma G.   +6 more
europepmc   +6 more sources

The Potential Therapeutic Applications of Natural Products in the Oxidative Stress-Related MVA Pathway: Focus on HMGCR. [PDF]

Antioxidants (Basel)
This review explores the therapeutic promise of natural compounds in modulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in cholesterol synthesis. HMGCR dysregulation is implicated in dyslipidemia, cardiovascular disease, and cancer, conditions linked to oxidative stress.
Teng YN.
europepmc   +4 more sources

Targeting the mevalonate pathway with statins overcomes acquired resistance to KRASG12C inhibitors in non-small cell lung cancer [PDF]

Experimental Hematology & Oncology
The emergence of covalent KRASG12C inhibitors has revolutionized the treatment of non-small cell lung cancer (NSCLC), yet acquired resistance remains a major clinical challenge.
Weihao Lin, Qi-an Chen, Yannan Yang, Yibo Gao, Jie He   +4 more
doaj   +2 more sources

Time-series transcriptome analysis reveals the cascade mechanism of biological processes following the perturbation of the MVA pathway in Salvia miltiorrhiza. [PDF]

Plant Mol Biol
Various biological processes are interconnected in plants. Transcription factors (TFs) often act as regulatory hubs to regulate plant growth and responses to stress by integrating various biological pathways. Despite extensive studies on TFs functions in various plant species, our understanding of the details of TFs regulation remains limited.
Liu F, Li N, Yan ZY, Chen X.
europepmc   +3 more sources

Biosynthesis of Isoprene Units in Euphorbia lathyris Laticifers vs. Other Tissues: MVA and MEP Pathways, Compartmentation and Putative Endophytic Fungi Contribution [PDF]

Molecules, 2019
Euphorbia species are characterized by a net of laticifers producing large amounts of triterpenes. These hydrocarbon-like metabolites can be converted into fuel by the methods of the oil industry. Euphorbia lathyris is easily grown at an industrial scale.
Agata Lipko, Philippe Schaeffer, Michel Rohmer   +2 more
exaly   +3 more sources

Mevalonic acid exerts procoagulant effect by potentiating factor Xa [PDF]

Natural Products and Bioprospecting
Thrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood.
Liyuan Niu, Chuanfeng Liu, Shaoying Wang, Qikai Yin, Shiping Lin, Musan Yan, Wenshuo Li, Yuanjie Yin, Wei Wang, Wenjuan Yu, Xiaopeng Tang, Min Xue, Yuewei Wang   +12 more
doaj   +2 more sources

Enhanced isoprenoid production in Escherichia coli cells harboring the archaeal mevalonate pathway [PDF]

Biochemistry and Biophysics Reports
Microbial production of isoprenoids has attracted interest as a white biotechnology approach that yields valuable compounds, such as medicinal, biofuel, and sustainable industrial materials.
Takuya Takahashi, Takuya Saito, Irori Dohgami, Tomokazu Ito, Hisashi Hemmi   +4 more
doaj   +2 more sources