Synthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway [PDF]
Microbial Cell Factories, 2021 Background Cembranoids are one kind of diterpenoids with multiple biological activities. The tobacco cembratriene-ol (CBT-ol) and cembratriene-diol (CBT-diol) have high anti-insect and anti-fungal activities, which is attracting great attentions for ...
Yu Zhang +9 more
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Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. [PDF]
PLoS ONE, 2012 The depleting petroleum reserve, increasingly severe energy crisis, and global climate change are reigniting enthusiasm for seeking sustainable technologies to replace petroleum as a source of fuel and chemicals.
Jianming Yang +7 more
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Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli [PDF]
Microbial Cell Factories, 2022 Background Lycopene is increasing in demand due to its widespread use in the pharmaceutical and food industries. Metabolic engineering and synthetic biology technologies have been widely used to overexpress the heterologous mevalonate pathway and ...
Tao Cheng +3 more
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Enhanced isoprenoid production in Escherichia coli cells harboring the archaeal mevalonate pathway [PDF]
Biochemistry and Biophysics ReportsMicrobial production of isoprenoids has attracted interest as a white biotechnology approach that yields valuable compounds, such as medicinal, biofuel, and sustainable industrial materials.
Takuya Takahashi +4 more
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Mevalonic acid exerts procoagulant effect by potentiating factor Xa [PDF]
Natural Products and BioprospectingThrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood.
Liyuan Niu +12 more
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Advances in microbial mevalonolactone production: from fermentative mevalonate accumulation to downstream lactonization [PDF]
Engineering MicrobiologyMevalonolactone (MVAL) is a high-value feedstock for the cosmetic industry, with (R)-(-)-MVAL as the sole bioactive enantiomer. Chemical synthesis, which is the traditional method for MVAL production, is hindered by cumbersome procedures, low chiral ...
Hao Tang +7 more
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STING-mediated antiviral response: insights into MVA replication control in avian cells [PDF]
Microbiology SpectrumThe safety-tested Modified Vaccinia virus Ankara (MVA) is a well-characterized mutant virus widely used in fundamental research to elucidate the functions of Poxvirus host-interaction factors.
Teresa Brusco +11 more
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Cholesterol metabolism is altered in Rett syndrome: A study on plasma and primary cultured fibroblasts derived from patients [PDF]
, 2014 Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2) are responsible for the onset of the disease.
Di Tunno, Ilenia +6 more
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Frontiers in Microbiology, 2021 The mevalonate (MVA) pathway in eukaryotic organisms produces isoprenoids, sterols, ubiquinone, and dolichols. These molecules are vital for diverse cellular functions, ranging from signaling to membrane integrity, and from post-translational ...
Xinyu Yang +13 more
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Frontiers in Plant Science, 2022 It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi +11 more
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