Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. [PDF]
PLoS ONE, 2012 The depleting petroleum reserve, increasingly severe energy crisis, and global climate change are reigniting enthusiasm for seeking sustainable technologies to replace petroleum as a source of fuel and chemicals.
Jianming Yang +7 more
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Mitochondrial Targeting of MVA Pathway Triggers Severe Inhibition of Post-Squalene Cholesterol Biosynthesis: Transcriptomic and Proteomic Insights in Yeast [PDF]
MoleculesExpression of the mevalonate (MVA) pathway in yeast mitochondria is deployed at commercial scale for production of squalene, because mitochondria contain abundant acetyl-CoA, the starting molecule of the MVA pathway.
Nan Tang +3 more
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Mechanism of lovastatin in promoting ferroptosis of prostate cancer cells by regulating the mevalonate pathway [PDF]
European Journal of HistochemistryProstate cancer (PCa) is a common malignancy in men with limited therapeutic options at advanced stages. Statins, widely prescribed lipid-lowering agents, have demonstrated antitumor activity in PCa, but underlying mechanisms are not fully understood ...
Yanhong Xiao +6 more
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Synthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway [PDF]
Microbial Cell Factories, 2021 Background Cembranoids are one kind of diterpenoids with multiple biological activities. The tobacco cembratriene-ol (CBT-ol) and cembratriene-diol (CBT-diol) have high anti-insect and anti-fungal activities, which is attracting great attentions for ...
Yu Zhang +9 more
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The Mevalonate Pathway: Innovations, Applications, and Challenges in Biotechnology with Emphasis on Fungal Biology [PDF]
Journal of FungiThe mevalonate (MVA) pathway is a central metabolic route responsible for the biosynthesis of isoprenoids with broad biological and biotechnological relevance.
Aisel Valle Garay +16 more
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Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli [PDF]
Microbial Cell Factories, 2022 Background Lycopene is increasing in demand due to its widespread use in the pharmaceutical and food industries. Metabolic engineering and synthetic biology technologies have been widely used to overexpress the heterologous mevalonate pathway and ...
Tao Cheng +3 more
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Targeting the mevalonate pathway with statins overcomes acquired resistance to KRASG12C inhibitors in non-small cell lung cancer [PDF]
Experimental Hematology & OncologyThe emergence of covalent KRASG12C inhibitors has revolutionized the treatment of non-small cell lung cancer (NSCLC), yet acquired resistance remains a major clinical challenge.
Weihao Lin +4 more
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Mevalonate pathway rewiring driven by enhancer remodelling confers resistance to KRAS inhibitors in colorectal cancer [PDF]
Nature CommunicationsKRAS inhibitors (KRASi) have emerged as promising new cancer therapeutics for KRAS-mutant cancers; however, resistance remains a potential clinical challenge.
Yaoyu Guo +25 more
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Frontiers in Microbiology, 2021 The mevalonate (MVA) pathway in eukaryotic organisms produces isoprenoids, sterols, ubiquinone, and dolichols. These molecules are vital for diverse cellular functions, ranging from signaling to membrane integrity, and from post-translational ...
Xinyu Yang +13 more
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Frontiers in Plant Science, 2022 It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi +11 more
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