Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots. [PDF]
PLoS ONE, 2012 Salvia miltiorrhiza has been widely used in the treatment of coronary heart disease. Tanshinones, a group of diterpenoids are the main active ingredients in S. miltiorrhiza.
Dongfeng Yang +7 more
doaj +1 more source
The Evolutionary Rate Variation Among Genes of MVA and MEP Pathways in Plant Terpenoid Biosynthesis [PDF]
, 2020 Abstract Background: Terpenoids are one of the most important compounds in plants, play an significant biological defense and developmental roles in numerous plant species, and widely used for industrial chemicals. Many previous studies have completed the identification of terpenoid biosynthetic pathway and related genes.
Ji-peng Mao +4 more
openaire +1 more source
Reconstitution of the MVA pathway significantly improves the growth of TPI2 depletion mutants.
, 2022 A, reconstitution of the MVA pathway into the UPRT locus of the iTPI2 strain to generate the iTPI2compMVA line. Following a similar mevalonate bypass system established in P.
Zhipeng Niu (3519488) +8 more
core +1 more source
Microbial Cell Factories, 2021 Background Natural glycolysis encounters the decarboxylation of glucose partial oxidation product pyruvate into acetyl-CoA, where one-third of the carbon is lost at CO2.
Ying Li +6 more
doaj +1 more source
Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]
, 2012 Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175) +37 more
core +1 more source
MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer
Cell Death and Disease, 2023 The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate (
Yu-kun Zheng +10 more
doaj +1 more source
Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides
Microbial Biotechnology, 2020 Summary Advances in synthetic biology and metabolic engineering have proven the potential of introducing metabolic by‐passes within cell factories.
Enrico Orsi +6 more
doaj +1 more source
Microbial Biotechnology, 2022 Summary Mevalonate (MVA) pathway is the core for terpene and sterol biosynthesis, whose metabolic flux influences the synthesis efficiency of such compounds. Saccharomyces cerevisiae is an attractive chassis for the native active MVA pathway.
Surui Lu +6 more
doaj +1 more source
Discovery of a metabolic alternative to the classical mevalonate pathway
eLife, 2013 Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas +3 more
doaj +1 more source
Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes
iScience, 2023 Summary: The high thermogenic activity of brown adipose tissue (BAT) has received considerable attention. Here, we demonstrated the role of the mevalonate (MVA) biosynthesis pathway in the regulation of brown adipocyte development and survival.
Jungin Kwon +15 more
doaj +1 more source