Results 31 to 40 of about 16,944 (177)

Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides

Microbial Biotechnology, 2020
Summary Advances in synthetic biology and metabolic engineering have proven the potential of introducing metabolic by‐passes within cell factories.
Enrico Orsi, Jules Beekwilder, Dewi vanGelder, Adèle vanHouwelingen, Gerrit Eggink, Servé W.M. Kengen, Ruud A. Weusthuis   +6 more
doaj   +1 more source

Transcriptional characterization and response to defense elicitors of mevalonate pathway genes in cotton (Gossypium arboreum L.) [PDF]

PeerJ, 2019
The mevalonate (MVA) pathway is responsible for the biosynthesis of cytosolic terpenes including gossypol and its derivatives, which play an important role in the cotton plant’s defense against pathogens and herbivores.
Zhiqiang Zhang, Wei Liu, Zongbin Ma, Wei Zhu, Lin Jia   +4 more
doaj   +2 more sources

Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β‐alanine metabolism

Microbial Biotechnology, 2022
Summary Mevalonate (MVA) pathway is the core for terpene and sterol biosynthesis, whose metabolic flux influences the synthesis efficiency of such compounds. Saccharomyces cerevisiae is an attractive chassis for the native active MVA pathway.
Surui Lu, Chenyao Zhou, Xuena Guo, Zhengda Du, Yanfei Cheng, Zhaoyue Wang, Xiuping He   +6 more
doaj   +1 more source

Discovery of a metabolic alternative to the classical mevalonate pathway

eLife, 2013
Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas, Suzanne T Thomas, Gerard Manning, Joseph P Noel   +3 more
doaj   +1 more source

Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes

iScience, 2023
Summary: The high thermogenic activity of brown adipose tissue (BAT) has received considerable attention. Here, we demonstrated the role of the mevalonate (MVA) biosynthesis pathway in the regulation of brown adipocyte development and survival.
Jungin Kwon, Yu-Sheng Yeh, Satoko Kawarasaki, Hiroto Minamino, Yoshihito Fujita, Yuko Okamatsu-Ogura, Haruya Takahashi, Wataru Nomura, Shigenobu Matsumura, Rina Yu, Kazuhiro Kimura, Masayuki Saito, Nobuya Inagaki, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto   +15 more
doaj   +1 more source

Optimum conditions for regulating content change of secondary metabolites of Gentiana macrophylla by orthogonal method

Guangxi Zhiwu, 2023
Gentiana macrophylla is a traditional Chinese herbal medicine for treating jaundice, hepatitis, and stomachic and choleretic ailments, and its main secondary metabolites are secoiridiod glycosides represented by gentiopicroside.
Huanhuan FU, Yihan HE, Yangyang YIN, Wei HU, Ye YANG, Zhenggang YUE   +5 more
doaj   +1 more source

Additional file 1 of Synthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway

, 2021
Additional file 1: Figure S1. Diagrams of vector structures. Figure S2. Mass spectra of CBT-ol and GGPP. Figure S3. Yeast growth and cembranoid production by shake-flask cultivation. Table S1. Codon-optimized sequences of CBTS1 and CYP450. Table S2. Primers for vector construction. Table S3. Gradient mobile phase for UPLC assay.
Zhang, Yu, Bian, Shiquan, Liu, Xiaofeng, Fang, Ning, Wang, Chunkai, Liu, Yanhua, Du, Yongmei, Timko, Michael P., Zhang, Zhongfeng, Zhang, Hongbo   +9 more
openaire   +2 more sources

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Frontiers in Oncology, 2021
A hallmark of cancer cells includes a metabolic reprograming that provides energy, the essential building blocks, and signaling required to maintain survival, rapid growth, metastasis, and drug resistance of many cancers.
Borja Guerra, Carlota Recio, Haidée Aranda-Tavío, Miguel Guerra-Rodríguez, José M. García-Castellano, Leandro Fernández-Pérez   +5 more
doaj   +1 more source

Mechanism of lovastatin in promoting ferroptosis of prostate cancer cells by regulating the mevalonate pathway

European Journal of Histochemistry
Prostate cancer (PCa) is a common malignancy in men with limited therapeutic options at advanced stages. Statins, widely prescribed lipid-lowering agents, have demonstrated antitumor activity in PCa, but underlying mechanisms are not fully understood ...
Yanhong Xiao, Zhengdao Liu, Yougang Feng, Han Zhu, Bo Wang, Shulian Chen, Guobiao Liang   +6 more
doaj   +1 more source

Expanded Archaeal Genomes Shed New Light on the Evolution of Isoprenoid Biosynthesis

Microorganisms
Isoprenoids and their derivatives, essential for all cellular life on Earth, are particularly crucial in archaeal membrane lipids, suggesting that their biosynthesis pathways have ancient origins and play pivotal roles in the evolution of early life ...
Pengfei Zhu, Jialin Hou, Yixuan Xiong, Ruize Xie, Yinzhao Wang, Fengping Wang   +5 more
doaj   +1 more source