Results 31 to 40 of about 1,146,862 (173)

Optimum conditions for regulating content change of secondary metabolites of Gentiana macrophylla by orthogonal method

Guangxi Zhiwu, 2023
Gentiana macrophylla is a traditional Chinese herbal medicine for treating jaundice, hepatitis, and stomachic and choleretic ailments, and its main secondary metabolites are secoiridiod glycosides represented by gentiopicroside.
Huanhuan FU, Yihan HE, Yangyang YIN, Wei HU, Ye YANG, Zhenggang YUE   +5 more
doaj   +1 more source

Reconstitution of the MVA pathway significantly improves the growth of TPI2 depletion mutants.

, 2022
A, reconstitution of the MVA pathway into the UPRT locus of the iTPI2 strain to generate the iTPI2compMVA line. Following a similar mevalonate bypass system established in P.
Zhipeng Niu (3519488), Junlong Zhao (3586115), Lilan Xue (14197647), Mengyu Lyu (14197644), Congcong Lyu (10910788), Bang Shen (3580943), Shu Ye (44563), Jiaojiao Liu (1943275), Muxiao Li (6664868)   +8 more
core   +1 more source

Handbook for safe and ethical peer mentoring with women surviving domestic abuse

A handbook and associated policy documents for Pathway Project, Lichfield, Staffordshire. including process, confidentiality statement and processes to be followed when acting as a volunteer peer mentoring with women surviving domestic ...
Pathway Project, Lichfield, Gilbert, Beverley   +1 more
core   +4 more sources

Enhanced isoprenoid production in Escherichia coli cells harboring the archaeal mevalonate pathway

Biochemistry and Biophysics Reports
Microbial production of isoprenoids has attracted interest as a white biotechnology approach that yields valuable compounds, such as medicinal, biofuel, and sustainable industrial materials.
Takuya Takahashi, Takuya Saito, Irori Dohgami, Tomokazu Ito, Hisashi Hemmi   +4 more
doaj   +1 more source

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Frontiers in Oncology, 2021
A hallmark of cancer cells includes a metabolic reprograming that provides energy, the essential building blocks, and signaling required to maintain survival, rapid growth, metastasis, and drug resistance of many cancers.
Borja Guerra, Carlota Recio, Haidée Aranda-Tavío, Miguel Guerra-Rodríguez, José M. García-Castellano, Leandro Fernández-Pérez   +5 more
doaj   +1 more source

MVA-gBΔfur731 induces polyfunctional CD8⁺ T cell responses in immunized mice.

, 2022
CD8+ T cells positive for single cytokine activation markers IFNγ (A), TNFα (B), or IL-2 (C), or double positive cytokine activation markers IFNγ/TNFα (D), IL-2/TNFα (E), or IFNγ/IL-2 (F).
Paul D. Ling (12269724), Taylor Pursell (12269718), Jennifer L. Spencer Clinton (5234252), Jie Tan (339881), Rongsheng Peng (12269721)   +4 more
core   +1 more source

A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults. [PDF]

, 2004
BACKGROUND: Many malaria vaccines are currently in development, although very few have been evaluated for efficacy in the field. Plasmodium falciparum multiple epitope (ME)- thrombospondin-related adhesion protein (TRAP) candidate vaccines are designed ...
Greenwood, Brian M, Pauline Kaye, Hill Adrian S. V, Kaye, Pauline, Imoukhuede, Egeruan B, Gilbert, Sarah, Walraven, G, Vasee S Moorthy, Moorthy Vasee S, Hill, AS, Egeruan B Imoukhuede, Kalifa Bojang, Milligan Paul, Gilbert, Sarah C, Pinder Margaret, Walraven, Gijs, Margaret Pinder (1712), Gijs Walraven, Adrian S V Hill, Hill, Adrian SV, Imoukhuede, EB, Egeruan B Imoukhuede (57141), Brian M Greenwood (45474), Walraven Gijs, Bojang, Kalifa, Brian M Greenwood, Keating, S, Vasee S Moorthy (57140), Greenwood Brian M, Sarah C Gilbert, Gilbert, SC, Kalifa Bojang (57143), Greenwood, BM, Bojang, K, Paul Milligan (57142), Pauline Kaye (57145), Gijs Walraven (18413), Moorthy, Vasee S, Kaye, P, Gilbert Sarah C, Pinder, M, Keating, Sheila, Sarah C Gilbert (57146), Paul Milligan, Sheila Keating (57144), Milligan, Paul, Moorthy, VS, Adrian S. V Hill (57147), Bojang Kalifa, Kaye Pauline, Sheila Keating, Milligan, P, Margaret Pinder, Keating Sheila, Pinder, Margaret, Imoukhuede Egeruan B   +55 more
core   +2 more sources

The Identification of β-Ocimene Biosynthetic Pathway Through Mevalonate Acid (MVA) and 1-Deoxy-D-Xylulose 5-Phosphate (DXP) Pathways Using Crude Enzyme Extracts in Indonesian Bay Leaf/Salam Leaf (Syzygium polyanthum) [PDF]

, 2022
Salam leaf has a β-ocimene as a key volatile compound that gives a fresh aroma to the food when the salam leaves are involved in the cooking process. As a secondary metabolic product, enzymatic biosynthesis as the early stage of β-ocimene is a factor ...
Respati Tri Swasono, Supriyadi,, Supriyadi, Supriyadi, Yudi Pranoto, Supriyadi, Pratama, Bima Putra, Swasono, Respati Tri, Bima Putra Pratama, Pranoto, Yudi   +8 more
core   +1 more source

Expanded Archaeal Genomes Shed New Light on the Evolution of Isoprenoid Biosynthesis

Microorganisms
Isoprenoids and their derivatives, essential for all cellular life on Earth, are particularly crucial in archaeal membrane lipids, suggesting that their biosynthesis pathways have ancient origins and play pivotal roles in the evolution of early life ...
Pengfei Zhu, Jialin Hou, Yixuan Xiong, Ruize Xie, Yinzhao Wang, Fengping Wang   +5 more
doaj   +1 more source

MVA-gBΔfur731 induces polyfunctional CD4⁺ T cell responses in immunized mice.

, 2022
Percentage of CD4+ T cells positive for single cytokine activation markers IFNγ (A), TNFα (B), or IL-2 (C), or double positive cytokine activation markers IFNγ/TNFα (D), IL-2/TNFα (E), or IFNγ/IL-2 (F). CD4+ T cells isolated from splenocytes of immunized
Paul D. Ling (12269724), Taylor Pursell (12269718), Jennifer L. Spencer Clinton (5234252), Jie Tan (339881), Rongsheng Peng (12269721)   +4 more
core   +1 more source