Transcriptional characterization and response to defense elicitors of mevalonate pathway genes in cotton (Gossypium arboreum L.) [PDF]
PeerJ, 2019 The mevalonate (MVA) pathway is responsible for the biosynthesis of cytosolic terpenes including gossypol and its derivatives, which play an important role in the cotton plant’s defense against pathogens and herbivores.
Zhiqiang Zhang +4 more
doaj +2 more sources
Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]
, 2011 VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward +1 more
core +1 more source
PTEN as A Candidate Molecular Target That Links MVA Pathway and Anti-HER2 Therapy Resistance
IIUM Medical Journal Malaysia, 2022 Drug resistance remains a major problem hampering the success of targeted treatment in cancer therapy. Despite the promising future of targeted therapy, the occurrence of drug resistance leading to poor therapeutic response has been recorded in a large number of patients. The underlying mechanism however is not conclusive.
Rosmaizan Drahman +1 more
openaire +1 more source
MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer
Cell Death and Disease, 2023 The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate (
Yu-kun Zheng +10 more
doaj +1 more source
A comparative study of Gaussian Graphical Model approaches for genomic data [PDF]
, 2011 The inference of networks of dependencies by Gaussian Graphical models on high-throughput data is an open issue in modern molecular biology. In this paper we provide a comparative study of three methods to obtain small sample and high dimension estimates
Ancona, N. +5 more
core +2 more sources
Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides
Microbial Biotechnology, 2020 Summary Advances in synthetic biology and metabolic engineering have proven the potential of introducing metabolic by‐passes within cell factories.
Enrico Orsi +6 more
doaj +1 more source
Microbial Biotechnology, 2022 Summary Mevalonate (MVA) pathway is the core for terpene and sterol biosynthesis, whose metabolic flux influences the synthesis efficiency of such compounds. Saccharomyces cerevisiae is an attractive chassis for the native active MVA pathway.
Surui Lu +6 more
doaj +1 more source
The TriForC database : a comprehensive up-to-date resource of plant triterpene biosynthesis [PDF]
, 2018 Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds.
Bak, Soren +8 more
core +2 more sources
Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size [PDF]
, 2015 Modified vaccinia virus Ankara (MVA) is a candidate vaccine vector that is severely attenuated due to mutations acquired during several hundred rounds of serial passage in vitro.
Dobson, Bianca, Tscharke, David C.
core +1 more source
Discovery of a metabolic alternative to the classical mevalonate pathway
eLife, 2013 Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas +3 more
doaj +1 more source