Correction to: Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli. [PDF]
Microb Cell Fact, 2022 Cheng T, Wang L, Sun C, Xie C.
europepmc +3 more sources
Discover PlantsWithanolides are bioactive triterpenoids that require isoprene units viz., isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) as precursor molecule for their biosynthesis, mediated via two independent routes, the plastidial methyl ...
Prince Choyal +4 more
doaj +2 more sources
Communications BiologyThe progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang +8 more
doaj +2 more sources
Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways. [PDF]
PLoS ONE, 2013 Poxvirus vector Modified Vaccinia Virus Ankara (MVA) expressing HIV-1 Env, Gag, Pol and Nef antigens from clade B (termed MVA-B) is a promising HIV/AIDS vaccine candidate, as confirmed from results obtained in a prophylactic phase I clinical trial in ...
Juan García-Arriaza +4 more
doaj +5 more sources
Therapeutic Poxviruses Induce the Secretion of Immunostimulating and Anti-Tumoral Extracellular Vesicles. [PDF]
J Extracell VesiclesImmune cells infected by therapeutic poxviruses release increased amounts of extracellular vesicles bearing viral proteins and therapeutic payloads. Such EVs have the ability to activate a CD8+ T‐cell mediated antitumoral immune response and decrease tumor growth.
Walther L +12 more
europepmc +2 more sources
Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA) [PDF]
Cell Death & Disease, 2021 AbstractRegulated cell death frequently occurs upon infection by intracellular pathogens, and extent and regulation is often cell-type-specific. We aimed to identify the cell death-signaling pathways triggered in macrophages by infection with modified vaccinia virus Ankara (MVA), an attenuated strain of vaccinia virus used in vaccination.
Lioba Klaas +4 more
openaire +4 more sources
A novel MVA-mediated pathway for isoprene production in engineered E. coli [PDF]
BMC Biotechnology, 2016 To deal with the increasingly severe energy crisis and environmental consequences, biofuels and biochemicals generated from renewable resources could serve as a promising alternative for replacing petroleum as a source of fuel and chemicals, among which isoprene (2-methyl-1,3-butadiene) in particular is of great significance in that it is an important ...
Yang, Jianming +4 more
openaire +2 more sources
Frontiers in Plant Science, 2022 It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi +11 more
doaj +1 more source
Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways [PDF]
Microbial Cell Factories, 2014 β-carotene is a carotenoid compound that has been widely used not only in the industrial production of pharmaceuticals but also as nutraceuticals, animal feed additives, functional cosmetics, and food colorants. Currently, more than 90% of commercial β-carotene is produced by chemical synthesis.
Yang, Jianming, Guo, Lizhong
openaire +2 more sources
Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells
Frontiers in Cell and Developmental Biology, 2020 The hepatic mevalonate (MVA) pathway, responsible for cholesterol biosynthesis, is a therapeutically important metabolic pathway in clinical medicine. Using an unbiased transcriptomics approach, we uncover a novel role of Unc-51 like autophagy activating
Sangam Rajak +9 more
doaj +1 more source