Results 21 to 30 of about 1,146,862 (173)

MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization. [PDF]

, 2009
Human infections with highly pathogenic avian influenza viruses of the H5N1 subtype, frequently reported since 2003, result in high morbidity and mortality.
Sutter, G. (Gerd), Sutter Gerd, Rimmelzwaan, Guus F., Osterhaus, A.D.M.E. (Albert), Yasemin Suezer, Gerrie de Mutsert, Suezer, Yasemin, Geert van Amerongen, Löwer, Johannes, Fouchier Ron A. M., Osterhaus, Albert D. M. E., Kreijtz, Joost H. C. M., Mutsert, Gerrie de, Fouchier, Ron A. M., Fouchier, R.A.M. (Ron), Guus F Rimmelzwaan, van den Brand Judith M. A., Löwer Johannes, Johannes Löwer, Kreijtz, J.H.C.M. (Joost), Suezer, Y., Judith M A van den Brand, Suezer Yasemin, Mutsert, G. (Gerrie) de, Amerongen, G. (Geert) van, Rimmelzwaan Guus F., Brand, J.M.A. (Judith) van den, Joost H C M Kreijtz, Sutter, Gerd, Schwantes, Astrid, de Mutsert Gerrie, Brand, Judith M. A. van den, Osterhaus Albert D. M. E., Schwantes Astrid, Scwantes, A. (Astrid), Ron A M Fouchier, van Amerongen Geert, Albert D M E Osterhaus, Gerd Sutter, Astrid Schwantes, Rimmelzwaan, G.F. (Guus), Kreijtz Joost H. C. M., Amerongen, Geert van, Löwer, J., Fouchier, Ron A.M.; id_orcid, Scwantes, Astrid, van Amerongen, Geert, van den Brand, Judith M.A., Osterhaus, Albert D.M.E., Kreijtz, Joost H.C.M., de Mutsert, Gerrie   +50 more
core   +1 more source

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer

Cell Death and Disease, 2023
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate (
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu   +10 more
doaj   +1 more source

Functional replacement of isoprenoid pathways in Rhodobacter sphaeroides

Microbial Biotechnology, 2020
Summary Advances in synthetic biology and metabolic engineering have proven the potential of introducing metabolic by‐passes within cell factories.
Enrico Orsi, Jules Beekwilder, Dewi vanGelder, Adèle vanHouwelingen, Gerrit Eggink, Servé W.M. Kengen, Ruud A. Weusthuis   +6 more
doaj   +1 more source

MVA-gBΔfur731 induces anti-gB antibody responses in mice.

, 2022
Anti-gB-specific antibody titers in vaccine trial groups: (A) prime vaccine only, (B) prime and boost vaccines, (C), prime with 2 boost vaccines. Anti-gH-specific antibody titers in vaccine trial groups: (D) prime vaccine only, (E) prime and boost ...
Paul D. Ling (12269724), Taylor Pursell (12269718), Jennifer L. Spencer Clinton (5234252), Jie Tan (339881), Rongsheng Peng (12269721)   +4 more
core   +1 more source

Transcriptional characterization and response to defense elicitors of mevalonate pathway genes in cotton (Gossypium arboreum L.) [PDF]

PeerJ, 2019
The mevalonate (MVA) pathway is responsible for the biosynthesis of cytosolic terpenes including gossypol and its derivatives, which play an important role in the cotton plant’s defense against pathogens and herbivores.
Zhiqiang Zhang, Wei Liu, Zongbin Ma, Wei Zhu, Lin Jia   +4 more
doaj   +2 more sources

Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β‐alanine metabolism

Microbial Biotechnology, 2022
Summary Mevalonate (MVA) pathway is the core for terpene and sterol biosynthesis, whose metabolic flux influences the synthesis efficiency of such compounds. Saccharomyces cerevisiae is an attractive chassis for the native active MVA pathway.
Surui Lu, Chenyao Zhou, Xuena Guo, Zhengda Du, Yanfei Cheng, Zhaoyue Wang, Xiuping He   +6 more
doaj   +1 more source

PTEN as A Candidate Molecular Target That Links MVA Pathway and Anti-HER2 Therapy Resistance [PDF]

, 2022
Drug resistance remains a major problem hampering the success of targeted treatment in cancer therapy. Despite the promising future of targeted therapy, the occurrence of drug resistance leading to poor therapeutic response has been recorded in a large ...
Drahman, Rosmaizan, Mohd Nafi, Siti Norasikin   +1 more
core   +1 more source

Discovery of a metabolic alternative to the classical mevalonate pathway

eLife, 2013
Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas, Suzanne T Thomas, Gerard Manning, Joseph P Noel   +3 more
doaj   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
core   +2 more sources

Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes

iScience, 2023
Summary: The high thermogenic activity of brown adipose tissue (BAT) has received considerable attention. Here, we demonstrated the role of the mevalonate (MVA) biosynthesis pathway in the regulation of brown adipocyte development and survival.
Jungin Kwon, Yu-Sheng Yeh, Satoko Kawarasaki, Hiroto Minamino, Yoshihito Fujita, Yuko Okamatsu-Ogura, Haruya Takahashi, Wataru Nomura, Shigenobu Matsumura, Rina Yu, Kazuhiro Kimura, Masayuki Saito, Nobuya Inagaki, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto   +15 more
doaj   +1 more source