Biosynthesis of Isoprene Units in Euphorbia lathyris Laticifers vs. Other Tissues: MVA and MEP Pathways, Compartmentation and Putative Endophytic Fungi Contribution [PDF]
Molecules, 2019 Euphorbia species are characterized by a net of laticifers producing large amounts of triterpenes. These hydrocarbon-like metabolites can be converted into fuel by the methods of the oil industry. Euphorbia lathyris is easily grown at an industrial scale.
Gastaldo, Clément +5 more
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Synthetic and Systems Biotechnology, 2021 The stability and high productivity of heterogeneous terpenoid production in Escherichia coli expression system is one of the most key issues for its large scale industrialization. In the current study on taking lycopene biosynthesis as an example, an integrated Escherichia coli system has been generated successfully, which resulted into stable and ...
Muhammad Hammad Hussain +10 more
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Cloning and expression analysis of mevalonate kinase and phosphomevalonate kinase genes associated with the MVA pathway in Santalum album. [PDF]
Sci Rep, 2021 Abstract Sandalwood ( Santalum album L.) is highly valued for its fragrant heartwood and extracted oil. Santalols, which are the main components of that oil, are terpenoids, and these are biosynthesized via the mevalonic acid (MVA) pathway.
Niu M +6 more
europepmc +6 more sources
Correction to: Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli. [PDF]
Microb Cell Fact, 2022 Cheng T, Wang L, Sun C, Xie C.
europepmc +3 more sources
Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways. [PDF]
PLoS ONE, 2013 Poxvirus vector Modified Vaccinia Virus Ankara (MVA) expressing HIV-1 Env, Gag, Pol and Nef antigens from clade B (termed MVA-B) is a promising HIV/AIDS vaccine candidate, as confirmed from results obtained in a prophylactic phase I clinical trial in ...
Juan García-Arriaza +4 more
doaj +5 more sources
Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA) [PDF]
Cell Death & Disease, 2021 AbstractRegulated cell death frequently occurs upon infection by intracellular pathogens, and extent and regulation is often cell-type-specific. We aimed to identify the cell death-signaling pathways triggered in macrophages by infection with modified vaccinia virus Ankara (MVA), an attenuated strain of vaccinia virus used in vaccination.
Lioba Klaas +4 more
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The Potential Therapeutic Applications of Natural Products in the Oxidative Stress-Related MVA Pathway: Focus on HMGCR. [PDF]
Antioxidants (Basel)This review explores the therapeutic promise of natural compounds in modulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in cholesterol synthesis. HMGCR dysregulation is implicated in dyslipidemia, cardiovascular disease, and cancer, conditions linked to oxidative stress.
Teng YN.
europepmc +3 more sources
Time-series transcriptome analysis reveals the cascade mechanism of biological processes following the perturbation of the MVA pathway in Salvia miltiorrhiza. [PDF]
Plant Mol BiolVarious biological processes are interconnected in plants. Transcription factors (TFs) often act as regulatory hubs to regulate plant growth and responses to stress by integrating various biological pathways. Despite extensive studies on TFs functions in various plant species, our understanding of the details of TFs regulation remains limited.
Liu F, Li N, Yan ZY, Chen X.
europepmc +3 more sources
A novel MVA-mediated pathway for isoprene production in engineered E. coli [PDF]
BMC Biotechnology, 2016 To deal with the increasingly severe energy crisis and environmental consequences, biofuels and biochemicals generated from renewable resources could serve as a promising alternative for replacing petroleum as a source of fuel and chemicals, among which isoprene (2-methyl-1,3-butadiene) in particular is of great significance in that it is an important ...
Yang, Jianming +4 more
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Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways [PDF]
Microbial Cell Factories, 2014 β-carotene is a carotenoid compound that has been widely used not only in the industrial production of pharmaceuticals but also as nutraceuticals, animal feed additives, functional cosmetics, and food colorants. Currently, more than 90% of commercial β-carotene is produced by chemical synthesis.
Yang, Jianming, Guo, Lizhong
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