Results 11 to 20 of about 16,944 (177)

Advances in microbial mevalonolactone production: from fermentative mevalonate accumulation to downstream lactonization [PDF]

Engineering Microbiology
Mevalonolactone (MVAL) is a high-value feedstock for the cosmetic industry, with (R)-(-)-MVAL as the sole bioactive enantiomer. Chemical synthesis, which is the traditional method for MVAL production, is hindered by cumbersome procedures, low chiral ...
Hao Tang, Lihong Yin, Yiwen Jiang, Teng Xu, Ting Xue, Meimei Fu, Jianghao Chen, Jinshan Guo   +7 more
doaj   +2 more sources

Rationally optimized generation of integrated Escherichia coli with stable and high yield lycopene biosynthesis from heterologous mevalonate (MVA) and lycopene expression pathways

Synthetic and Systems Biotechnology, 2021
The stability and high productivity of heterogeneous terpenoid production in Escherichia coli expression system is one of the most key issues for its large scale industrialization. In the current study on taking lycopene biosynthesis as an example, an integrated Escherichia coli system has been generated successfully, which resulted into stable and ...
Hongqing Fang, Meijin Guo, Waqas Qamar Zaman   +2 more
exaly   +4 more sources

Correction to: Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli. [PDF]

Microb Cell Fact, 2022
Cheng T, Wang L, Sun C, Xie C.
europepmc   +3 more sources

Mitochondrial Targeting of MVA Pathway Triggers Severe Inhibition of Post-Squalene Cholesterol Biosynthesis: Transcriptomic and Proteomic Insights in Yeast

Molecules
Expression of the mevalonate (MVA) pathway in yeast mitochondria is deployed at commercial scale for production of squalene, because mitochondria contain abundant acetyl-CoA, the starting molecule of the MVA pathway.
Nan Tang, Yuliang Xu, Changfu Li, Yansheng Zhang   +3 more
doaj   +2 more sources

Coordinated carbon metabolite flux between the methyl erythritol phosphate (MEP) and the mevalonate (MVA) pathway regulates the withanolide biosynthesis in Withania somnifera (L.) Dunal

Discover Plants
Withanolides are bioactive triterpenoids that require isoprene units viz., isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) as precursor molecule for their biosynthesis, mediated via two independent routes, the plastidial methyl ...
Prince Choyal, Virendra Singh Rana, Maharishi Tomar, Kalidindi Usha, Bhupinder Singh   +4 more
doaj   +2 more sources

The Mevalonate Pathway Is Important for Growth, Spore Production, and the Virulence of Phytophthora sojae

Frontiers in Microbiology, 2021
The mevalonate (MVA) pathway in eukaryotic organisms produces isoprenoids, sterols, ubiquinone, and dolichols. These molecules are vital for diverse cellular functions, ranging from signaling to membrane integrity, and from post-translational ...
Xinyu Yang, Xinyu Yang, Xue Jiang, Weiqi Yan, Qifeng Huang, Huiying Sun, Xin Zhang, Zhichao Zhang, Wenwu Ye, Yuanhua Wu, Yuanhua Wu, Francine Govers, Yue Liang, Yue Liang   +13 more
doaj   +1 more source

Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis

Biochemical Journal, 2023
Isoprenoids, including dolichols (Dols) and polyprenols (Prens), are ubiquitous components of eukaryotic cells. In plant cells, there are two pathways that produce precursors utilized for isoprenoid biosynthesis: the mevalonate (MVA) pathway and the methylerythritol phosphate (MEP) pathway.
Agata Lipko, Cezary Pączkowski, Laura Perez-Fons, Paul D. Fraser, Magdalena Kania, Marta Hoffman-Sommer, Witold Danikiewicz, Michel Rohmer, Jaroslaw Poznanski, Ewa Swiezewska   +9 more
openaire   +3 more sources

Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA) [PDF]

Cell Death & Disease, 2021
AbstractRegulated cell death frequently occurs upon infection by intracellular pathogens, and extent and regulation is often cell-type-specific. We aimed to identify the cell death-signaling pathways triggered in macrophages by infection with modified vaccinia virus Ankara (MVA), an attenuated strain of vaccinia virus used in vaccination.
Lioba Klaas, Juliane Vier, Ian E. Gentle, Georg Häcker, Susanne Kirschnek   +4 more
openaire   +4 more sources

Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways

Frontiers in Plant Science, 2022
It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi, Hui Wei, Boas Pucker, Mostafa Ghaderi-Zefrehei, Fatemeh Rasouli, Fatemeh Rasouli, Ali Kiani-Pouya, Ali Kiani-Pouya, Tingbo Jiang, Qiang Zhuge, Liming Yang, Xiaohong Zhou   +11 more
doaj   +1 more source

A novel MVA-mediated pathway for isoprene production in engineered E. coli [PDF]

BMC Biotechnology, 2016
To deal with the increasingly severe energy crisis and environmental consequences, biofuels and biochemicals generated from renewable resources could serve as a promising alternative for replacing petroleum as a source of fuel and chemicals, among which isoprene (2-methyl-1,3-butadiene) in particular is of great significance in that it is an important ...
Yang, Jianming, Nie, Qingjuan, Liu, Hui, Xian, Mo, Liu, Huizhou   +4 more
openaire   +2 more sources