Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. [PDF]
PLoS Pathogens, 2011 Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure.
Pedro Eitz Ferrer +10 more
doaj +3 more sources
Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges. [PDF]
Adv Sci (Weinh)Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Chen F +6 more
europepmc +2 more sources
Clinical Characteristics and Timing of Accessory Pathway Reconduction During Catheter Ablation of Accessory Pathways. [PDF]
J ArrhythmIntra‐procedural accessory pathway reconduction occurred in 18% of patients, with 65.2% of events detected ≥ 15 min after initial pathway elimination. Reconduction was associated with a higher rate of late recurrence, supporting careful assessment for conduction recovery during the post‐ablation waiting period.
Sasaki W +11 more
europepmc +2 more sources
Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots. [PDF]
PLoS ONE, 2012 Salvia miltiorrhiza has been widely used in the treatment of coronary heart disease. Tanshinones, a group of diterpenoids are the main active ingredients in S. miltiorrhiza.
Dongfeng Yang +7 more
doaj +1 more source
Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells
Frontiers in Cell and Developmental Biology, 2020 The hepatic mevalonate (MVA) pathway, responsible for cholesterol biosynthesis, is a therapeutically important metabolic pathway in clinical medicine. Using an unbiased transcriptomics approach, we uncover a novel role of Unc-51 like autophagy activating
Sangam Rajak +9 more
doaj +1 more source
Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis [PDF]
, 2023 Isoprenoids, including dolichols (Dols) and polyprenols (Prens), are ubiquitous components of eukaryotic cells. In plant cells, there are two pathways that produce precursors utilized for isoprenoid biosynthesis: the mevalonate (MVA) pathway and the ...
Hoffman-Sommer, Marta +9 more
core +1 more source
Cell Death and Disease, 2023 p140Cap is an adaptor protein involved in assembling multi-protein complexes regulating several cellular processes. p140Cap acts as a tumor suppressor in breast cancer (BC) and neuroblastoma patients, where its expression correlates with a better ...
Giorgia Centonze +21 more
doaj +1 more source
Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2012 Isoprenoids, which are a large group of natural and chemical compounds with a variety of applications as e.g. fragrances, pharmaceuticals and potential biofuels, are produced via two different metabolic pathways, the mevalonate (MVA) pathway and the 2-C ...
Siavash Partow +4 more
doaj +1 more source
Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants? [PDF]
, 2010 Background: Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses.
Jochen Steinmann +8 more
core +2 more sources
Microbial Cell Factories, 2021 Background Natural glycolysis encounters the decarboxylation of glucose partial oxidation product pyruvate into acetyl-CoA, where one-third of the carbon is lost at CO2.
Ying Li +6 more
doaj +1 more source