Results 41 to 50 of about 16,941 (145)

Combinatorial transient gene expression strategies to enhance terpenoid production in plants

Frontiers in Plant Science, 2022
IntroductionThe monoterpenoid linalool and sesquiterpenoid costunolide are ubiquitous plant components that have been economically exploited for their respective essential oils and pharmaceutical benefits.
Soyoung Park, Vimalraj Mani, Jin A. Kim, Soo In Lee, Kijong Lee   +4 more
doaj   +1 more source

The Mevalonate Pathway: Innovations, Applications, and Challenges in Biotechnology with Emphasis on Fungal Biology

Journal of Fungi
The mevalonate (MVA) pathway is a central metabolic route responsible for the biosynthesis of isoprenoids with broad biological and biotechnological relevance.
Aisel Valle Garay, Cíntia Marques Coelho, Napoleão Fonseca Valadares, Leonardo Ferreira da Silva, Letícia Sousa Cabral, Matheus de Castro Leitão, Luiza Cesca Piva, Janice Lisboa De Marco, Brenda Rabello de Camargo, Amanda Araújo Souza, Izadora Cristina Moreira de Oliveira, Matheus Ferroni Schwartz, Túlio Marcos Godoy de Andrade, Talita Souza Carmo, João Ricardo Moreira de Almeida, Fernando Araripe Gonçalves Torres, Sonia Maria de Freitas   +16 more
doaj   +1 more source

Farnesyl pyrophosphate is a new danger signal inducing acute cell death.

PLoS Biology, 2021
Cell death is a vital event in life. Infections and injuries cause lytic cell death, which gives rise to danger signals that can further induce cell death, inflammation, and tissue damage.
Jing Chen, Xiaochen Zhang, Liping Li, Xianqiang Ma, Chunxiao Yang, Zhaodi Liu, Chenyang Li, Maria J Fernandez-Cabezudo, Basel K Al-Ramadi, Chuan Wu, Weishan Huang, Yong Zhang, Yonghui Zhang, Wanli Liu   +13 more
doaj   +1 more source

Molecular Cloning and Analysis of an Acetyl-CoA C-acetyltransferase Gene (EkAACT) from Euphorbia kansui Liou

Plants, 2022
Terpenoids are the largest class of natural products and are essential for cell functions in plants and their interactions with the environment. Acetyl-CoA acetyltransferase (AACT, EC2.3.1.9) can catalyze a key initiation step of the mevalonate pathway ...
Meng Wang, Zhe Zheng, Zheni Tian, Hao Zhang, Chenyu Zhu, Xiangyu Yao, Yixin Yang, Xia Cai   +7 more
doaj   +1 more source

Changing biosynthesis of terpenoid percursors in rice through synthetic biology

Frontiers in Plant Science, 2023
Many highly valued chemicals in the pharmaceutical, biotechnological, cosmetic, and biomedical industries belong to the terpenoid family. Biosynthesis of these chemicals relies on polymerization of Isopentenyl di-phosphate (IPP) and/or dimethylallyl ...
Orio Basallo, Orio Basallo, Lucia Perez, Lucia Perez, Abel Lucido, Abel Lucido, Albert Sorribas, Albert Sorribas, Alberto Marin-Saguino, Alberto Marin-Saguino, Ester Vilaprinyo, Ester Vilaprinyo, Laura Perez-Fons, Alfonso Albacete, Alfonso Albacete, Cristina Martínez-Andújar, Paul D. Fraser, Paul Christou, Paul Christou, Paul Christou, Teresa Capell, Teresa Capell, Rui Alves, Rui Alves   +23 more
doaj   +1 more source

Dynamics of Monoterpene Formation in Spike Lavender Plants

Metabolites, 2017
The metabolic cross-talk between the mevalonate (MVA) and the methylerythritol phosphate (MEP) pathways was analyzed in spike lavender (Lavandula latifolia Med) on the basis of 13CO2-labelling experiments using wildtype and transgenic plants ...
Isabel Mendoza-Poudereux, Erika Kutzner, Claudia Huber, Juan Segura, Isabel Arrillaga, Wolfgang Eisenreich   +5 more
doaj   +1 more source

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +1 more source

Squalene Biosynthesis in Engineered Escherichia Coli

Pharmaceutical Fronts, 2023
Squalene is a natural triterpenoid that is important in medicine, and daily-use chemical and nutraceutical industries. The demand for squalene remains high and constant.
Wei Zhang, Yuan Li, Li-Ping Xie, You-Jia Hu   +3 more
doaj   +1 more source

Single-nucleotide polymorphism markers within MVA and MEP pathways among Hevea brasiliensis clones through transcriptomic analysis

3 Biotech, 2019
In this study, RNA sequencing of several Hevea brasiliensis clones grown in Malaysia with different annual rubber production yields and disease resistance was performed on the Illumina platform. A total of 29,862,548 reads were generated, resulting in 101,269 assembled transcripts that were used as the reference transcripts. A similarity search against
Siti Nurfazilah, Abdul Rahman, Mohd Fahmi Abu, Bakar, G Veera, Singham, Ahmad Sofiman, Othman   +3 more
openaire   +3 more sources

Effect of Enzyme Inhibitors on Terpene Trilactones Biosynthesis and Gene Expression Profiling in Cultured Cells

Natural Product Communications, 2015
The biosynthetic pathway of terpene trilactones of Ginkgo biloba is unclear. In this present study, suspension cultured cells of G. biloba were used to explore the regulation of the mevalonic acid (MVA) and methylerythritol 4-phosphate (MEP) pathways in ...
Lijia Chen, Hui Tong, Mingxuan Wang, Jianhua Zhu, Jiachen Zi, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source