Results 41 to 50 of about 26,893 (208)
Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes
iScience, 2023 Summary: The high thermogenic activity of brown adipose tissue (BAT) has received considerable attention. Here, we demonstrated the role of the mevalonate (MVA) biosynthesis pathway in the regulation of brown adipocyte development and survival.
Jungin Kwon +15 more
doaj +1 more source
Tuberculosis vaccine: pipeline approaches and future prospective [PDF]
, 2011 Tuberculosis (TB), despite anti-mycobacterial therapies and vaccine, is a deadly infectious disease with about 12 million incident cases worldwide. Existing Bacillus Calmette-Guérin (BCG) vaccine is unquestionably inexpensive, safe and effective ...
Ankita Singh +2 more
core +2 more sources
Guangxi Zhiwu, 2023 Gentiana macrophylla is a traditional Chinese herbal medicine for treating jaundice, hepatitis, and stomachic and choleretic ailments, and its main secondary metabolites are secoiridiod glycosides represented by gentiopicroside.
Huanhuan FU +5 more
doaj +1 more source
Influenza and memory T cells : how to awake the force [PDF]
, 2016 Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen +12 more
core +3 more sources
The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Frontiers in Oncology, 2021 A hallmark of cancer cells includes a metabolic reprograming that provides energy, the essential building blocks, and signaling required to maintain survival, rapid growth, metastasis, and drug resistance of many cancers.
Borja Guerra +5 more
doaj +1 more source
Inhibition of geranylgeranyl diphosphate synthesis in in vitro systems [PDF]
, 1985 The incorporation of [14C]mevalonate and [14C]isopentenyl diphosphate into geranylgeranyl diphosphate was investigated in in vitro systems from Cucurbita pepo (pumpkin) endosperm and from Avena sativa etioplasts.
Mitzka-Schnabel, Ursula +4 more
core +1 more source
696 Single-cell RNA-seq reveals the critical roles of the STING- and MDA5-mediated cytosolic nucleic acid-sensing pathways as well as IFNAR/STAT2 signaling in recombinant MVA-induced antitumor immunity [PDF]
Regular and Young Investigator Award Abstracts, 2021 Background Oncolytic viruses are promising therapeutic agents for advanced cancers because of their ability to induce antitumor innate and adaptive immunity. Modified vaccinia virus Ankara (MVA) is an attenuated, replication-deficient poxvirus safe for human use, making it a favorable platform for cancer immunotherapy. Previously we discovered the E5R
Shuaitong Liu +11 more
openaire +2 more sources
Diminished Intracellular Invariant Chain Expression Following Vaccinia Virus Infection [PDF]
, 2009 Vaccinia virus (VV) has been used as a vaccine to eradicate smallpox and as a vaccine for HIV and tumors. However, the immunoevasive properties of VV, have raised safety concerns.
Blum, Janice S. +2 more
core +1 more source
3 Biotech, 2019 In this study, RNA sequencing of several Hevea brasiliensis clones grown in Malaysia with different annual rubber production yields and disease resistance was performed on the Illumina platform. A total of 29,862,548 reads were generated, resulting in 101,269 assembled transcripts that were used as the reference transcripts. A similarity search against
Siti Nurfazilah, Abdul Rahman +3 more
openaire +3 more sources
Additional file 1 of Synthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway
, 2021 Additional file 1: Figure S1. Diagrams of vector structures. Figure S2. Mass spectra of CBT-ol and GGPP. Figure S3. Yeast growth and cembranoid production by shake-flask cultivation. Table S1. Codon-optimized sequences of CBTS1 and CYP450. Table S2. Primers for vector construction. Table S3. Gradient mobile phase for UPLC assay.
Zhang, Yu +9 more
openaire +2 more sources