Results 61 to 70 of about 17,684 (224)

Disease Site‐Specific Outcomes in p16‐Positive Non‐Oropharyngeal Mucosal Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Objectives To report disease‐free survival (DFS) in p16‐positive non‐oropharyngeal head‐and‐neck squamous‐cell carcinoma (HNSCC). Methods Curatively‐treated non‐oropharyngeal HNSCC (2009–2021) were reviewed. DFS was compared among p16‐positive, p16‐negative, and p16‐untested cases for the overall cohort and by disease site.
Revadhi C. Chelvarajah, Lessandra Y. S. Chee, Jie Su, Brian O'Sullivan, Christopher M. K. L. Yao, Enrique Sanz‐Garcia, Stephen M. Smith, Ilan Weinreb, Scott Bratman, B. C. John Cho, Ezra Hahn, Andrew Hope, Ali Hosni, John Kim, Andrew McPartlin, Nauman Malik, Chiaojung Jillian Tsai, John de Almeida, Anna Spreafico, Li Tong, Shao Hui Huang, John N Waldron   +21 more
wiley   +1 more source

Changing biosynthesis of terpenoid percursors in rice through synthetic biology

Frontiers in Plant Science, 2023
Many highly valued chemicals in the pharmaceutical, biotechnological, cosmetic, and biomedical industries belong to the terpenoid family. Biosynthesis of these chemicals relies on polymerization of Isopentenyl di-phosphate (IPP) and/or dimethylallyl ...
Orio Basallo, Orio Basallo, Lucia Perez, Lucia Perez, Abel Lucido, Abel Lucido, Albert Sorribas, Albert Sorribas, Alberto Marin-Saguino, Alberto Marin-Saguino, Ester Vilaprinyo, Ester Vilaprinyo, Laura Perez-Fons, Alfonso Albacete, Alfonso Albacete, Cristina Martínez-Andújar, Paul D. Fraser, Paul Christou, Paul Christou, Paul Christou, Teresa Capell, Teresa Capell, Rui Alves, Rui Alves   +23 more
doaj   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Image_8_The Mevalonate Pathway Is Important for Growth, Spore Production, and the Virulence of Phytophthora sojae.TIF

, 2022
The mevalonate (MVA) pathway in eukaryotic organisms produces isoprenoids, sterols, ubiquinone, and dolichols. These molecules are vital for diverse cellular functions, ranging from signaling to membrane integrity, and from post-translational ...
Xue Jiang (411020), Huiying Sun (338156), Weiqi Yan (5793062), Xin Zhang (35492), Wenwu Ye (154887), Yuanhua Wu (5237519), Qifeng Huang (11866166), Yue Liang (2294437), Francine Govers (52155), Zhichao Zhang (530603), Xinyu Yang (197010)   +10 more
core   +1 more source

Mitochondrial Targeting of MVA Pathway Triggers Severe Inhibition of Post-Squalene Cholesterol Biosynthesis: Transcriptomic and Proteomic Insights in Yeast

Molecules
Expression of the mevalonate (MVA) pathway in yeast mitochondria is deployed at commercial scale for production of squalene, because mitochondria contain abundant acetyl-CoA, the starting molecule of the MVA pathway.
Nan Tang, Yuliang Xu, Changfu Li, Yansheng Zhang   +3 more
doaj   +1 more source

Dynamics of Monoterpene Formation in Spike Lavender Plants

Metabolites, 2017
The metabolic cross-talk between the mevalonate (MVA) and the methylerythritol phosphate (MEP) pathways was analyzed in spike lavender (Lavandula latifolia Med) on the basis of 13CO2-labelling experiments using wildtype and transgenic plants ...
Isabel Mendoza-Poudereux, Erika Kutzner, Claudia Huber, Juan Segura, Isabel Arrillaga, Wolfgang Eisenreich   +5 more
doaj   +1 more source

Diverging perspectives on emerging mental health symptoms: Multi‐informant discrepancies and their associated determinants across the transition to adolescence in the Adolescent Brain Cognitive Development Study

JCPP Advances, EarlyView.
Abstract Background The transition from childhood to adolescence is marked by significant developmental, social, and contextual changes that present practical challenges for the measurement of emerging mental health symptoms. This study explores transdiagnostic symptoms across three core dimensions from the Achenbach system of empirically based ...
Matias Martinez, Vijay A. Mittal, Jonathan D. Schaefer, Claudia M. Haase, Katherine S. F. Damme   +4 more
wiley   +1 more source

Two models (with and without outlier) for prediction of bicyclogermacrene concentrations from transcript levels of MEP and MVA pathway genes.

, 2013
Two models (with and without outlier) for prediction of bicyclogermacrene concentrations from transcript levels of MEP and MVA pathway genes.
Robert Lanfear (395145), John Hamill (395148), William J. Foley (395149), Carsten Külheim (395150), Hamish Webb (395143)   +4 more
core   +1 more source

Data_Sheet_1_The Mevalonate Pathway Is Important for Growth, Spore Production, and the Virulence of Phytophthora sojae.docx

, 2022
The mevalonate (MVA) pathway in eukaryotic organisms produces isoprenoids, sterols, ubiquinone, and dolichols. These molecules are vital for diverse cellular functions, ranging from signaling to membrane integrity, and from post-translational ...
Xue Jiang (411020), Huiying Sun (338156), Weiqi Yan (5793062), Xin Zhang (35492), Wenwu Ye (154887), Yuanhua Wu (5237519), Qifeng Huang (11866166), Yue Liang (2294437), Francine Govers (52155), Zhichao Zhang (530603), Xinyu Yang (197010)   +10 more
core   +1 more source

Fetal Heart Rate at 12 Weeks' Gestation and the Risk of Preterm Birth

Journal of Ultrasound in Medicine, EarlyView.
Objectives To prospectively validate the association between fetal heart rate (FHR) at the 12‐week scan and the risk of preterm birth (PTB), including spontaneous preterm birth (sPTB). Methods This prospective cohort study included 1276 singleton pregnancies undergoing routine first‐trimester screening at 11–13 + 6 weeks' gestation and followed until ...
José Morales‐Roselló, Alicia Soriano‐Payá, Blanca Novillo‐Del Álamo, Alicia Martínez‐Varea   +3 more
wiley   +1 more source