Results 71 to 80 of about 26,893 (208)

Quantification of Urinary Mevalonic Acid as a Biomarker of HMG-CoA Reductase Activity by a Novel Translational LC-MS/MS Method [PDF]

, 2014
Background: Mevalonic acid (MVA), as a product of 3-hydroxy-3-methylglutaryl coenzyme A reductase, represents a potential multipurpose biomarker in health and disease. A translational urinary MVA quantification method was developed, validated and used to
Antoine, Daniel J, Coen, Muireann, Maggs, James L, McWilliam, Stephen J, Park, B Kevin, Pirmohamed, Munir, Rodrigues, Alison VM, Wilson, Ian D   +7 more
core   +1 more source

Fetal Heart Rate at 12 Weeks' Gestation and the Risk of Preterm Birth

Journal of Ultrasound in Medicine, EarlyView.
Objectives To prospectively validate the association between fetal heart rate (FHR) at the 12‐week scan and the risk of preterm birth (PTB), including spontaneous preterm birth (sPTB). Methods This prospective cohort study included 1276 singleton pregnancies undergoing routine first‐trimester screening at 11–13 + 6 weeks' gestation and followed until ...
José Morales‐Roselló, Alicia Soriano‐Payá, Blanca Novillo‐Del Álamo, Alicia Martínez‐Varea   +3 more
wiley   +1 more source

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +1 more source

Effect of Enzyme Inhibitors on Terpene Trilactones Biosynthesis and Gene Expression Profiling in Cultured Cells

Natural Product Communications, 2015
The biosynthetic pathway of terpene trilactones of Ginkgo biloba is unclear. In this present study, suspension cultured cells of G. biloba were used to explore the regulation of the mevalonic acid (MVA) and methylerythritol 4-phosphate (MEP) pathways in ...
Lijia Chen, Hui Tong, Mingxuan Wang, Jianhua Zhu, Jiachen Zi, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source

A novel virotherapy encoding human interleukin-7 improves ex vivo T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19

Frontiers in Immunology, 2022
A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a state of immunosuppression contributing to their worsening.
Morgane Crausaz, Morgane Crausaz, Guillaume Monneret, Guillaume Monneret, Filippo Conti, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Jean-Baptiste Marchand, Perrine Martin, Geneviève Inchauspé, Fabienne Venet, Fabienne Venet   +11 more
doaj   +1 more source

Effective Equilibrium Reaction Zone Modeling of Hydrogen Plasma Smelting Reduction: A Scenario Analysis

steel research international, EarlyView.
The study presents a dynamic zonal model for hydrogen plasma smelting reduction (HPSR) in direct current arc furnaces, predicting time‐dependent behavior of metal, slag, and off‐gas. The study considers various industrial scenarios to quantify energy demand, hydrogen utilization, degree of reduction, and other operational sensitivities.
Tristan K. Wickham, Stephanus P. Du Preez, Dmitri G. Bessarabov, Stephan C. Louw, Ernst L. J. Kleynhans   +4 more
wiley   +1 more source

Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng

BMC Genomics, 2019
Background Panax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes.
Le Xue, Zilong He, Xiaochun Bi, Wei Xu, Ting Wei, Shuangxiu Wu, Songnian Hu   +6 more
doaj   +1 more source

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway

Journal of Hepatocellular Carcinoma, 2023
Kailin Xing,1,* Xinyu Bian,2,* Dongmin Shi,3,* Shuangshuang Dong,1 Hongxin Zhou,1 Shuxiu Xiao,4 Jinjin Bai,4 Weizhong Wu1,4 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion ...
Xing K, Bian X, Shi D, Dong S, Zhou H, Xiao S, Bai J, Wu W   +7 more
doaj  

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source