Results 81 to 90 of about 17,684 (224)

Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins [PDF]

, 2022
Ewing sarcoma (EwS) is an aggressive primary bone cancer in children and young adults characterized by oncogenic fusions between genes encoding FET-RNA-binding proteins and ETS transcription factors, the most frequent fusion being EWSR1-FLI1.
Delattre, Olivier; https://orcid.org/, Gentric, Géraldine; https://orcid.org/, van der Ent, Wietske, Grossetête, Sandrine, Müller, Kévin, Del Nery, Elaine; https://orcid.org/, Laud-Duval, Karine, Buchou, Charlie; https://orcid.org/, Surdez, Didier; https://orcid.org/, Corbé, Maxime; https://orcid.org/, Zaidi, Sakina   +10 more
core   +1 more source

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng

BMC Genomics, 2019
Background Panax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes.
Le Xue, Zilong He, Xiaochun Bi, Wei Xu, Ting Wei, Shuangxiu Wu, Songnian Hu   +6 more
doaj   +1 more source

Dysregulation of the mevalonate pathway promotes transformation

, 2010
The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood.
Anna Martirosyan, Razqallah Hakem, Paul C. Boutros, Samah El Ghamrasni, Fereshteh Khosravi, James W. Clendening, Linda Z. Penn, Anne Hakem, Igor Jurisica, Grace A. Trentin, Aleks Pandyra   +10 more
core   +1 more source

Transcriptome sequencing of Salvia miltiorrhiza after infection by its endophytic fungi and identification of genes related to tanshinone biosynthesis

Pharmaceutical Biology, 2019
Context: Salvia miltiorrhiza Bunge (Labiatae) is a traditional Chinese herb. Endophytic fungi, which are biotic elicitors, can induce accumulation of secondary metabolites in their host plants.
Yan Jiang, Lei Wang, Shaorong Lu, Yizhe Xue, Xiying Wei, Juan Lu, Yanyan Zhang   +6 more
doaj   +1 more source

Enhancement of linalool production in Saccharomyces cerevisiae by utilizing isopentenol utilization pathway

Microbial Cell Factories, 2022
Background Linalool is a monoterpenoid, also a vital silvichemical with commercial applications in cosmetics, flavoring ingredients, and medicines. Regulation of mevalonate (MVA) pathway metabolic flux is a common strategy to engineer Saccharomyces ...
Yaoyao Zhang, Xianshuang Cao, Jin Wang, Feng Tang   +3 more
doaj   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

, 2012
Microbial production can be advantageous over the extraction of phytoterpenoids from natural plant sources, but it remains challenging to rationally and rapidly access efficient pathway variants.
Jin, Guojie, HuangLuqi, Zhou, Yongjin J., Zhu, Zhiwei, Gao, Wei, Chu, Huiying, Li, Guohui, Liu, Wujun, Yang, Wei, Huang, Luqi, Zhao, Zongbao K., Rong, Qixian, Zhu, Guofeng   +12 more
core   +1 more source

Toward industrial production of isoprenoids in Escherichia coli: Lessons learned from CRISPR-Cas9 based optimization of a chromosomally integrated mevalonate pathway [PDF]

, 2018
Escherichia coli has been the organism of choice for the production of different chemicals by engineering native and heterologous pathways. In the present study, we simultaneously address some of the main issues associated with E.
Alonso-Gutierrez, Jorge, Lee, Taek S., Claudia E. Vickers, Adams, Paul D, Nielsen, Lars K, Keasling, Jay D., Vickers, Claudia E, Daisuke Koma, Jay D. Keasling, Chan, Leanne JG, Yuchen Yang, Qijun Hu, Petzold, Christopher J., Chan, Leanne J.G., Keasling, Jay D, Yang, Yuchen, Adams, Paul D., Taek S. Lee, Vickers, Claudia E., Alonso‐Gutierrez, Jorge, Koma, Daisuke, Jorge Alonso‐Gutierrez, Nielsen, Lars K., Petzold, Christopher J, Lee, Taek S, Lars K. Nielsen, Hu, Qijun, Paul D. Adams, Leanne J. G. Chan, Christopher J. Petzold   +29 more
core   +1 more source

miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway

Journal of Hepatocellular Carcinoma, 2023
Kailin Xing,1,* Xinyu Bian,2,* Dongmin Shi,3,* Shuangshuang Dong,1 Hongxin Zhou,1 Shuxiu Xiao,4 Jinjin Bai,4 Weizhong Wu1,4 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion ...
Xing K, Bian X, Shi D, Dong S, Zhou H, Xiao S, Bai J, Wu W   +7 more
doaj