Results 81 to 90 of about 1,146,862 (173)

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design. [PDF]

, 2018
BACKGROUND: We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and (ii) the impact of boosting with modified vaccinia virus Ankara (HIV-MVA) administered with or ...
Arne Kroidl, Leonard Maboko, Munseri, Patricia J., Ilesh V Jani, Jonathan Weber (59115), Wolfgang Stöhr, Weber, Jonathan, Sheena McCormack, Scarlatti, Gabriella, Sarah Joseph (140503), Geldmacher, Christof, Gabriella Scarlatti, Michael Hoelscher (151418), Asli Bauer (543776), Agricola Joachim, Joseph, Sarah, Edna O Viegas, Wolfgang Stöhr (408365), Sandström, Eric, Viegas, Edna O, Wahren, Britta, Lyamuya, Eligius, Aboud, Said, Asli Bauer, Jonathan Weber, Said Aboud (214830), Sue Fleck (606802), Marco Missanga, Maboko, Leonard, Stöhr, Wolfgang, Sarah Joseph, Missanga, Marco, Charlotta Nilsson, Sue Fleck, Kroidl, Arne, Philipp Mann, Arne Kroidl (723934), Christof Geldmacher (317649), Bauer, Asli, Leonard Maboko (175605), Joachim, Agricola, Robb, Merlin L, Jani, Ilesh, Bakari, Muhammad, Gunnel Biberfeld (512861), Eric Sandström (3169440), Eligius Lyamuya (389001), Nelson Tembe (563935), Robb, Merlin L., Charlotta Nilsson (563943), Fleck, Sue, Merlin L. Robb (132305), Ilesh V. Jani (144106), Hoelscher, Michael, Biberfeld, Gunnel, Nelson Tembe, Gunnel Biberfeld, Michael Hoelscher, Patricia J Munseri, Muhammad Bakari, Tembe, Nelson, Britta Wahren (2324), Merlin L Robb, Sheena McCormack (308068), Nilsson, Charlotte, TaMoVac study group, Said Aboud, Britta Wahren, Marco Missanga (723937), Viegas, Edna O., Edna O. Viegas (6029246), McCormack, Sheena, Munseri, Patricia J, Christof Geldmacher, Eligius Lyamuya, Nilsson, Charlotta, Muhammad Bakari (316249), Eric Sandström, Philipp Mann (723935), Jani, Ilesh V, Agricola Joachim (723257), Gabriella Scarlatti (165846), Patricia J. Munseri (3169443), Mann, Philipp   +83 more
core   +1 more source

Mevalonic acid exerts procoagulant effect by potentiating factor Xa

Natural Products and Bioprospecting
Thrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood.
Liyuan Niu, Chuanfeng Liu, Shaoying Wang, Qikai Yin, Shiping Lin, Musan Yan, Wenshuo Li, Yuanjie Yin, Wei Wang, Wenjuan Yu, Xiaopeng Tang, Min Xue, Yuewei Wang   +12 more
doaj   +1 more source

Metabolomic Mapping of Greek Olive Leaves by Untargeted NMR‐Based Profiling and LC–HRMS Dereplication

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT Olive tree leaves are phytochemically rich yet insufficiently valorised in terms of systematic cultivar‐based characterisation and exploitation, and are an abundant olive industry side‐product. This study represents the first large‐scale metabolome mapping based on 340 leaf extracts from five major Greek cultivars (Amfissis, Koroneiki, Manaki,
Mariacaterina Lianza, Stavros Beteinakis, Vasileios Siderakis, Panagiotis Stathopoulos, Emmanuel Hatzakis, Maria Halabalaki   +5 more
wiley   +1 more source

Mevalonate Diphosphate Decarboxylase MVD/Erg19 Is Required for Ergosterol Biosynthesis, Growth, Sporulation and Stress Tolerance in Aspergillus oryzae

Frontiers in Microbiology, 2019
Mevalonate diphosphate decarboxylase (MVD; EC 4.1.1.33) is a key enzyme of the mevalonic acid (MVA) pathway. In fungi, the MVA pathway functions as upstream of ergosterol biosynthesis, and MVD is also known as Erg19.
Yunlong Sun, Yali Niu, Hui Huang, Bin He, Long Ma, Yayi Tu, Van-Tuan Tran, Van-Tuan Tran, Bin Zeng, Zhihong Hu   +9 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

p53 regulates the mevalonate pathway in human glioblastoma multiforme. [PDF]

, 2015
The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway including 3'-hydroxy-3 ...
D'Alessandro A, Picardi P, Malfitano AM, Comegna M, Ciaglia E, Pisanti S, Laezza C, Bifulco M, Gazzerro P, Di Croce L, Faraonio R   +10 more
core   +2 more sources

An audit to determine the clinical effectiveness of a pathway for managing wound infection [PDF]

, 2015
Prevention of wound infection is a key objective in the planning of care for patients with wounds. The potential for wound infection, particularly in chronic wounds that are heavily contaminated with bacteria, can be high (Bowler et al, 2001).
Stephenson, John, Grothier, Lorraine
core   +3 more sources

Tracing the biosynthetic origin of limonoids and their functional groups through stable isotope labeling and inhibition in neem tree (Azadirachta indica) cell suspension

BMC Plant Biology, 2018
Background Neem tree serves as a cornucopia for triterpenoids called limonoids that are of profound interest to humans due to their diverse biological activities.
Thiagarayaselvam Aarthy, Fayaj A. Mulani, Avinash Pandreka, Ashish Kumar, Sharvani S. Nandikol, Saikat Haldar, Hirekodathakallu V. Thulasiram   +6 more
doaj   +1 more source

Efficacy and safety of frail patients treated with ciltacabtagene autoleucel in the real world: A Center for International Blood and Marrow Transplant Research analysis

Cancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background Ciltacabtagene autoleucel (cilta‐cel), an anti–B‐cell maturation antigen (BCMA) chimeric antigen receptor T‐cell (CAR‐T) therapy, is approved for relapsed/refractory multiple myeloma (RRMM). Methods Using the Center for International Blood and Marrow Transplant Research registry, this study evaluated outcomes of frail patients ...
Hira Mian, Muhammad Salman Faisal, Tiening Chen, Ruta Brazauskas, Temitope Oloyede, Nausheen Ahmed, Aimaz Afrough, Larry D. Anderson, Rahul Banerjee, Jesus Berdeja, Aram Bidikian, Jakob Devos, Binod Dhakal, Ajoy Dias, Danai Dima, Yvonne A. Efebera, Lohith Gowda, Doris K. Hansen, Hamza Hashmi, Heather J. Landau, Lazaros Lekakis, Abu‐Sayeef Mirza, Ravi Narra, Krina Patel, Ashley E. Rosko, Mark Schroeder, Surbhi Sidana, Saad Usmani, Marcelo C. Pasquini, Taiga Nishihori, Othman Salim Akhtar, Meera Mohan   +31 more
wiley   +1 more source