Results 91 to 100 of about 17,684 (224)

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer, Guiseppa de Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Sequential administration of MVA-based vaccines and PD-1/PD-L1-blocking antibodies confers measurable benefits on tumor growth and survival: Preclinical studies with MVA-βGal and MVA-MUC1 (TG4010) in a murine tumor model

, 2017
TG4010, a Modified Vaccinia virus Ankara (MVA) expressing human mucin1 (MUC1) has demonstrated clinical benefit for patients suffering from advanced non-small cell lung cancer (NSCLC) in combination with chemotherapy.
Xavier Préville, Eric Quemeneur, Karola Rittner, Kaïdre Bendjama, Murielle Gantzer, Christelle Remy-Ziller, Christine Thioudellet, Virginie Nourtier, Marie-Christine Claudepierre, Julie Hortelano, Benoit Sansas   +10 more
core   +1 more source

Additional file 1 of Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli

, 2022
Additional file 1: Table S1. Primers used in this study. Figure S1. Ten colonies were randomly picked and analyzed by colony PCR to determine ratio of successfully assembled pHM-library, pMM-library, and pLM-library. M marker.
Cheng, Tao, Wang, Lili, Sun, Chao, Xie, Congxia   +3 more
openaire   +1 more source

Updates and controversies in contemporary grading of clear cell renal cell carcinoma and papillary renal cell carcinoma

Histopathology, EarlyView.
New concepts, innovations and some issues have emerged since the adoption a decade ago of WHO/ISUP grading for CCRCC and PRCC. Continued use of the WHO/ISUP grading for CCRCC and PRCC has been upheld by newer studies, and practice guidance for some of the grading issues, where data are available, is provided.
Gladell P. Paner, Mahul. B. Amin, Jung Woo Kwon, Liang Cheng, Holger Moch   +4 more
wiley   +1 more source

Signaling pathways induced upon MVA-C infection of mDCs and pDCs.

, 2012
Selected significant top 10 pathways and their genes members resulting from comparing myeloid DCs infected with MVA-C (MDC_MVC) and mock-infected (MDC_Mock) groups (A) or plasmacytoid DCs infected with MVA-C (PDC_MVC) and mock-infected (PDC_Mock) groups (
Julie Delaloye (123020), Cornelis J. M. Melief (170042), Victoria Jiménez (123025), Rafick P. Sékaly (170038), Antonio Lanzavecchia (75057), Mariano Esteban (50256), Khader Ghneim (170017), Federica Sallusto (75054), Elias K. Haddad (141833), Ralf Wagner (143451), Beatriz Perdiguero (123011), Thierry Calandra (123030), Alexandre Harari (10437), Esther D. Quakkerlaar (170023), Giuseppe Pantaleo (10464), Abdelali Filali-Mouhim (170014), Thomas Dunhen (170033), Carmen Elena Gómez (123013), Thierry Roger (123027)   +18 more
core   +1 more source

Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus

Frontiers in Microbiology, 2018
In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureusΔmvaS mutant can revert to prototrophy. This mutant couldn’t grow in the absence of MVA.
Sebastian Reichert, Patrick Ebner, Eve-Julie Bonetti, Arif Luqman, Mulugeta Nega, Jacques Schrenzel, Cathrin Spröer, Boyke Bunk, Jörg Overmann, Peter Sass, Patrice François, Friedrich Götz   +11 more
doaj   +1 more source

3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis

Scientific Reports, 2023
Isoprenoids, a large kind of plant natural products, are synthesized by the mevalonate (MVA) pathway in the cytoplasm and the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway in plastids. As one of the rate-limiting enzymes in the MVA pathway of soybean
Shuai Wang, Yumei Feng, Yin Lou, Jingping Niu, Congcong Yin, Jinzhong Zhao, Weijun Du, Aiqin Yue   +7 more
doaj   +1 more source

Nursing‐Led Knowledge Translation Strategies to Improve Patient Safety in Hospital Settings: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To conduct a scoping review of nurse‐led Knowledge Translation strategies aimed at promoting and enhancing patient safety in hospital settings. Design Scoping review. Methods This review followed the Joanna Briggs Institute methodology and was reported according to PRISMA‐ScR.
Jhenyfer Amanda Ciriaco Canhete, Vânia Ana Silveira Muniz, Milene Negri Reiser, Chantal Backman, Gabriela Marcellino de Melo Lanzoni, Ana Lúcia Schaefer Ferreira de Mello   +5 more
wiley   +1 more source

KIF11 manipulates SREBP2‐dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma

Cancer Medicine, 2022
Cholesterol metabolism is highly correlated with risks of pancreatic ductal adenocarcinoma (PDAC). Nevertheless, the underlying mechanisms of activation of cholesterol biogenesis remain inconclusive.
Xiang Gu, Qunshan Zhu, Guangyu Tian, Wenbo Song, Tao Wang, Ali Wang, Xiaojun Chen, Songbing Qin   +7 more
doaj   +1 more source

Towards an integrated molecular understanding of plant hormones

Journal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain, Marie‐Laure Fauconnier, Manon Genva   +2 more
wiley   +1 more source