Results 91 to 100 of about 16,944 (177)

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.

PLoS Pathogens, 2014
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to understand how MVA modulates innate immunity in dendritic cells (DCs), which can provide insights ...
Peihong Dai, Weiyi Wang, Hua Cao, Francesca Avogadri, Lianpan Dai, Ingo Drexler, Johanna A Joyce, Xiao-Dong Li, Zhijian Chen, Taha Merghoub, Stewart Shuman, Liang Deng   +11 more
doaj   +1 more source

Seismic Characteristics of the Gas Hydrate System in the Mackenzie Trough of the Canadian Beaufort Sea, Arctic Ocean

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 8, August 2026.
Abstract We present a comprehensive seismic characterization of the gas hydrate system in the outer continental shelf of the Mackenzie Trough, Canadian Beaufort Sea, based on recently acquired multichannel seismic (MCS) data, P‐wave velocity modeling, and 3D thermal modeling. We identified high‐amplitude, reverse‐polarity Bottom‐Simulating Reflections (
Yeonjin Choi, Young Keun Jin, Michael Riedel, Jong Kuk Hong, Mathieu J. Duchesne, Sung‐Ryul Shin, Wookeen Chung, Seung‐Goo Kang   +7 more
wiley   +1 more source

The Role of the Hyoid Bone in Obstructive Sleep Apnea Severity: A Systematic Review

Journal of Sleep Research, Volume 35, Issue 4, August 2026.
ABSTRACT Obstructive sleep apnea (OSA) has numerous complications that negatively impact patients' quality of life. Early diagnosis can significantly reduce these complications. The aim of the study was to evaluate the relationship between the hyoid bone position and the severity of apnea, and to determine if hyoid‐related cephalometric variables can ...
Carmen María Correa‐Morillo, Paola Cardil París, Marta Macarena Paz‐Cortés, Andrea Martín‐Vacas, Giovanni Giovannini   +4 more
wiley   +1 more source

Hazel (Corylus avellana L.) as a New Source of Taxol and Taxanes

Journal of Medicinal Plants, 2012
Taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the AIDS-related Karposi’s carcinoma, and was originally obtained from bark of taxus brevifolia.
A Qaderi, M Omidi, A Etminan, A Oladzad, C Ebrahimi, MR Dehghani Mashkani, A Mehrafarin   +6 more
doaj  

Predictors of Relapse and Post‐Relapse Outcomes After Frontline Blinatumomab in Philadelphia Chromosome‐Negative B‐ALL

American Journal of Hematology, Volume 101, Issue 8, Page 2038-2043, August 2026.
Sankalp Arora, Hagop Kantarjian, Koji Sasaki, Nitin Jain, Zhouxuan Li, Wei Qiao, Sanam Loghavi, Guilin Tang, Caitlin Rausch, Farhad Ravandi, Fadi G. Haddad, Jayastu Senapati, Guillermo Montalban Bravo, Alexandre Bazinet, Rita Khouri, Rebecca Garris, Guillermo Garcia‐Manero, Nicholas J. Short, Elias Jabbour   +18 more
wiley   +1 more source

STING-mediated antiviral response: insights into MVA replication control in avian cells

Microbiology Spectrum
The safety-tested Modified Vaccinia virus Ankara (MVA) is a well-characterized mutant virus widely used in fundamental research to elucidate the functions of Poxvirus host-interaction factors.
Teresa Brusco, Valentina Menci, Carmen Caiazza, Anna Maria Petrone, Renata Palladino, Matteo Faticanti, Veronica Bignone, Concetta Ambrosino, Elisa Scarselli, Massimo Mallardo, Loredana Siani, Valentino Ruzza   +11 more
doaj   +1 more source

RNA-seq analysis reveals narrow differential gene expression in MEP and MVA pathways responsible for phytochemical divergence in extreme genotypes of Thymus daenensis Celak

BMC Genomics
Abstract Background Here, we investigated the underlying transcriptional-level evidence behind phytochemical differences between two metabolically extreme genotypes of Thymus daenensis. The genotypes ‘Zagheh-11’ (thymol/carvacrol type, poor in essential oil [EO] [2.9%] but rich in triterpenic acids) and ‘Malayer-21 ...
Ahmadi, Hosein, Fatahi, Reza, Zamani, Zabihollah, Shokrpour, Majid, Sheikh-Assadi, Morteza, Poczai, Péter   +5 more
openaire   +4 more sources

Yeast metabolism adaptation for efficient terpenoids synthesis via isopentenol utilization

Nature Communications
Microbial biosynthesis has become the leading commercial approach for large-scale production of terpenoids, a valuable class of natural products. Enhancing terpenoid production, however, requires complex modifications on the host organism.
Guangjian Li, Hui Liang, Ruichen Gao, Ling Qin, Pei Xu, Mingtao Huang, Min-Hua Zong, Yufei Cao, Wen-Yong Lou   +8 more
doaj   +1 more source

Time-series transcriptome analysis reveals the cascade mechanism of biological processes after perturbation of the MVA pathway in Salvia miltiorrhiza

Abstract Background Various biological processes are interconnected in plants. Transcription factors (TFs) often act as regulatory hubs to regulate plant growth and responses to stress by integrating various biological pathways. Despite extensive studies on TFs functions in various plant species, our understanding of the details of TFs ...
Fang Liu, Nan Li, Zhu-Yun Yan, Xin Chen
openaire   +1 more source

Squalene in <i>Camellia oleifera</i>: Biosynthetic Pathways, Regulatory Networks, and Functional Perspectives. [PDF]

Plants (Basel)
Wang A, Wang J, Deng S, Chen B, Zhang J, Ma L.   +5 more
europepmc   +1 more source