Results 111 to 120 of about 1,146,862 (173)

Yeast metabolism adaptation for efficient terpenoids synthesis via isopentenol utilization

Nature Communications
Microbial biosynthesis has become the leading commercial approach for large-scale production of terpenoids, a valuable class of natural products. Enhancing terpenoid production, however, requires complex modifications on the host organism.
Guangjian Li, Hui Liang, Ruichen Gao, Ling Qin, Pei Xu, Mingtao Huang, Min-Hua Zong, Yufei Cao, Wen-Yong Lou   +8 more
doaj   +1 more source

Dysregulation of the mevalonate pathway promotes transformation

, 2010
The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood.
Anna Martirosyan, Razqallah Hakem, Paul C. Boutros, Samah El Ghamrasni, Fereshteh Khosravi, James W. Clendening, Linda Z. Penn, Anne Hakem, Igor Jurisica, Grace A. Trentin, Aleks Pandyra   +10 more
core   +1 more source

Sequential administration of MVA-based vaccines and PD-1/PD-L1-blocking antibodies confers measurable benefits on tumor growth and survival: Preclinical studies with MVA-βGal and MVA-MUC1 (TG4010) in a murine tumor model

, 2017
TG4010, a Modified Vaccinia virus Ankara (MVA) expressing human mucin1 (MUC1) has demonstrated clinical benefit for patients suffering from advanced non-small cell lung cancer (NSCLC) in combination with chemotherapy.
Xavier Préville, Eric Quemeneur, Karola Rittner, Kaïdre Bendjama, Murielle Gantzer, Christelle Remy-Ziller, Christine Thioudellet, Virginie Nourtier, Marie-Christine Claudepierre, Julie Hortelano, Benoit Sansas   +10 more
core   +1 more source

Constructing Haloarchaeal MVA Pathway in Serratia marcescens for Synthesis of Ocimene. [PDF]

Biotechnol Appl Biochem
Yao S, Liu D, Wang L, Fan T, Deng H, Cai Y.   +5 more
europepmc   +1 more source

The Potential Therapeutic Applications of Natural Products in the Oxidative Stress-Related MVA Pathway: Focus on HMGCR. [PDF]

Antioxidants (Basel)
Teng YN.
europepmc   +1 more source

Time-series transcriptome analysis reveals the cascade mechanism of biological processes following the perturbation of the MVA pathway in Salvia miltiorrhiza. [PDF]

Plant Mol Biol
Liu F, Li N, Yan ZY, Chen X.
europepmc   +1 more source

Characterisation of metabolic burden in Pseudomonas putida reveals precursor limitation in heterologous lycopene production. [PDF]

Microb Cell Fact
Meiners C, Hermann L, Stoja M, Kremling A, Pflüger-Grau K.   +4 more
europepmc   +1 more source

Implementation of the synthetic arabinose 5-phosphate dependent glycolaldehyde assimilation (SAGA) pathway in <i>Pseudomonas putida</i>. [PDF]

Front Bioeng Biotechnol
Titze A, Wagner N, Frazão CJR, Walther T.   +3 more
europepmc   +1 more source

Integrating Machine Learning and Transcriptomics to Enhance β‑Carotene Production in <i>Saccharomyces cerevisiae</i>. [PDF]

ACS Omega
Khamwachirapithak P, Sae-Tang K, Bubphasawan S, Choompuper J, Zhao XQ, Champreda V, Runguphan W.   +6 more
europepmc   +1 more source

Sclareol Production Driven by Advanced Synthetic Biology Strategies. [PDF]

ACS Omega
Yu Y, Wang L, Zhang Y, Zhang R, Shah AA, Gong C.   +5 more
europepmc   +1 more source