Results 131 to 140 of about 17,684 (224)

RNA-seq analysis reveals narrow differential gene expression in MEP and MVA pathways responsible for phytochemical divergence in extreme genotypes of Thymus daenensis Celak

open access: yesBMC Genomics
Abstract Background Here, we investigated the underlying transcriptional-level evidence behind phytochemical differences between two metabolically extreme genotypes of Thymus daenensis. The genotypes ‘Zagheh-11’ (thymol/carvacrol type, poor in essential oil [EO] [2.9%] but rich in triterpenic acids) and ‘Malayer-21 ...
Ahmadi, Hosein   +5 more
openaire   +4 more sources

Umbelliprenin in Food and Medicinal Plants: Phytochemical Occurrence, Biosynthesis, Analytical Approaches, and Biological Activities

open access: yesPhytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio   +4 more
wiley   +1 more source

Genome‐wide analysis of the AP2/ERF gene family in Rheum officinale Baill.: Evolution and expression profiling during plant development, abiotic stresses, and exogenous hormone responses

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract The APETALA2/ethylene‐responsive factor (AP2/ERF) superfamily plays a central role in plant metabolism, stress responses, and hormone signaling. Rheum officinale Baill. is an important traditional medicinal plant whose roots and rhizomes are rich in anthraquinones and other secondary metabolites.
Jing Tang   +9 more
wiley   +1 more source

Yeast metabolism adaptation for efficient terpenoids synthesis via isopentenol utilization

open access: yesNature Communications
Microbial biosynthesis has become the leading commercial approach for large-scale production of terpenoids, a valuable class of natural products. Enhancing terpenoid production, however, requires complex modifications on the host organism.
Guangjian Li   +8 more
doaj   +1 more source

Immune Cell Composition and Prognosis in Node‐Positive, Irradiated Breast Cancer Patients in the DBCG‐IMN2 Study

open access: yesAPMIS, Volume 134, Issue 6, June 2026.
ABSTRACT High levels of tumor‐infiltrating lymphocytes (TILs) are associated with improved survival after radiotherapy in breast cancer (BC) patients, particularly in estrogen receptor (ER)‐negative disease. This study investigated the prognostic relevance of immune cell subsets in irradiated patients.
Demet Özcan   +7 more
wiley   +1 more source

CRISPR interference-guided balancing of a biosynthetic mevalonate pathway increases terpenoid production

open access: yes, 2016
Methods for simple and efficient regulation of metabolic pathway genes are essential for maximizing product titers and conversion yields, and for minimizing the metabolic burden caused by heterologous expression of multiple genes often in the operon ...
S W Kim   +6 more
core   +1 more source

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

open access: yesThe FEBS Journal, Volume 293, Issue 11, Page 3303-3319, June 2026.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa   +9 more
wiley   +1 more source

Evaluation of the effectiveness and safety of anti‐CGRP monoclonal antibodies in patients with migraine and autoimmune diseases: IMMUNO‐CGRP study

open access: yesHeadache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1330-1341, June 2026.
Plain Language Summary Recent studies have found an association between migraine and several chronic inflammatory diseases, such as multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis, suggesting that these conditions might share common immune and vascular pathways.
María Clara García‐Castillo   +37 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 4204-4220, June 2026.
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou   +12 more
wiley   +1 more source

Scheme of CK biosynthesis through plastidic MEP- and cytosolic MVA-pathway.

open access: yes, 2015
Black arrows show the biosynthesis, interconversions and metabolism flow of CKs in Arabidopsis cell (adapted from [121]). The dashed arrow indicates the iPRMP-independent pathway of tZ biosynthesis [104].
Adriana Ricarte-Bermejo (713271)   +14 more
core   +1 more source

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