Results 151 to 160 of about 16,978 (182)

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

Annual Review of Plant Biology, 2013
Isoprenoid biosynthesis is essential for all living organisms, and isoprenoids are also of industrial and agricultural interest. All isoprenoids are derived from prenyl diphosphate (prenyl-PP) precursors. Unlike isoprenoid biosynthesis in other living organisms, prenyl-PP, as the precursor of all isoprenoids in plants, is synthesized by two ...
Eva Vranová, Diana Coman, Wilhelm Gruissem   +2 more
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Identification and bioinformatics analysis of genes associated with MVA pathway in Magnolia officinalis

China Journal of Chinese Materia Medica, 2015
Methyl valerate (MVA) pathway is one of the important ways for synthesis of terpenoids. This study was based on data of the transcriptome sequencing of Magnolia officinalis, the associated genes MoACOT, MoHMGS, MoHMGR, MoMK in methyl valerate (MVA) pathway, were completed in detail by using bioinformatics methods.
Liang-ping, Zha, Yuan, Yuan, Lu-qi, Huang, Shu-lin, Yu   +3 more
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Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1

Chemico-Biological Interactions, 2023
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high morbidity and mortality. Targeting abnormal cholesterol metabolism is a potential therapeutic direction. Therefore, more natural drugs targeting cholesterol in HCC need to be developed.
Man-Yu Xiao, Fang-Fang Li, Peng Xie, Yan-Shuang Qi, Jin-Bo Xie, Wen-Jing Pei, Hao-Tian Luo, Mei Guo, Yu-Long Gu, Xiang-Lan Piao   +9 more
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Utilisation of the MVA pathway to produce elevated levels of the sesquiterpene α-copaene in potato tubers

Phytochemistry, 2011
Potato flavour is a complex trait resulting from the presence of a combination of volatile and non-volatile compounds. The aim of this work was to investigate the effect of specifically altering the volatile content of tubers and assess its impact on flavour. Tuber-specific over-expression of a potato α-copaene synthase gene resulted in enhanced levels
Wayne L, Morris, Laurence J M, Ducreux, Tom, Shepherd, Efraim, Lewinsohn, Rachel, Davidovich-Rikanati, Yaron, Sitrit, Mark A, Taylor   +6 more
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Constructing Haloarchaeal MVA Pathway in Serratia marcescens for Synthesis of Ocimene

Biotechnology and Applied Biochemistry
ABSTRACT Ocimene, a valuable monoterpene with applications in agriculture, pharmaceuticals, and fragrances, is challenging to produce at high yields using traditional microbial platforms such as Escherichia coli and Saccharomyces cerevisiae
Songsong, Yao, Di, Liu, Long, Wang, TaiPing, Fan, Huaxiang, Deng, Yujie, Cai   +5 more
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[Effects of tHMGR from three different plant sources on mevalonate (MVA) pathway flux in Saccharomyces cerevisiae].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022
In this study, we used bioinformatic tools to analyze the 3-hydroxy-3-methylglutaryl-CoA reductase(HMGR) genes from Glycyrrhiza uralensis, Artemisia annua, and Arabidopsis thaliana. The results indicated that GuHMGR and AaHMGR contained two transmembrane regions while AtHMGR had three transmembrane regions. GuHMGR, AaHMGR, and AtHMGR all had the active
Xiao-Li, Zhang, Er-Kun, Chao, Meng-Chu, Sun, Hong-Fei, Zhao, Cai-Xia, Wang, Bo-Lin, Zhang   +5 more
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The MVA pathway genes expressions and accumulation of celastrol in Tripterygium wilfordii suspension cells in response to methyl jasmonate treatment

Journal of Asian Natural Products Research, 2016
Celastrol is an important bioactive triterpenoid in traditional Chinese medicinal plant, Tripterygium wilfordii. Methyl Jasmonate (MJ) is a common plant hormone which can regulate the secondary metabolism in higher plants. In this study, the mevalonate (MVA) pathway genes in T. wilfordii were firstly cloned. The suspension cells of T.
Yu-Jia, Liu, Yu-Jun, Zhao, Ping, Su, Meng, Zhang, Yu-Ru, Tong, Tian-Yuan, Hu, Lu-Qi, Huang, Wei, Gao   +7 more
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Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway

Plant Cell Reports, 2014
HMGS functions in phytosterol biosynthesis, development and stress responses. F-244 could specifically-inhibit HMGS in tobacco BY-2 cells and Brassica seedlings. An update on HMGS from higher plants is presented. 3-Hydroxy-3-methylglutaryl-coenzyme A synthase (HMGS) is the second enzyme in the mevalonate pathway of isoprenoid biosynthesis and catalyzes
Liao, P., Wang, H., Hemmerlin, A., Nagegowda, D.A., Bach, T.J., Wang, M., Chye, M.L.   +6 more
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Metabolic engineering of the MVA pathway for isoprenoid production in plants

2017
Invited talk - Session 3: Biotechnology and bioengineering (I) : OL5, p ...
Liao, P, Wang, H, Chen, X, Wang, M, Bach, T J, Chye, ML   +5 more
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High-Efficiency Synthesis of β-Caryophyllene in Serratia marcescens via an Aeropyrum-Type MVA Pathway and Enzyme Engineering

Journal of Agricultural and Food Chemistry
β-caryophyllene is a high-value natural bicyclic sesquiterpenoid compound. In this study, a highly efficient biosynthetic system for β-caryophyllene was first constructed using the terpene-tolerant Serratia marcescens as the chassis. By introducing the energy-efficient Aeropyrum-type mevalonate (MVA) pathway and rationally designing the active pocket ...
Chengbo Xie, Di Liu, Linbo Gou, Shengfang Wu, Xiuwen Zhou, Tai-Ping Fan, Long Wang, Yujie Cai   +7 more
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