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Plant Biotechnology Journal, Volume 24, Issue 6, Page 4342-4357, June 2026.ABSTRACT The basic helix–loop–helix (bHLH) transcription factor family regulates plant secondary metabolism, development and stress responses. Although triterpenoids such as betulinic acid (BA), betulin (BT) and oleanolic acid (OA) from Betula platyphylla Suk.
Ying Li +9 more
wiley +1 more source
, 2015 Expression status of all genes depicted as fold increase, for P-I and P-II biosynthetic pathways in Picrorhiza kurroa: MVA and MEP pathway genes data from Pandit et al. (2012).
Neha Sharma (433468) +4 more
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Abstract Background Various biological processes are interconnected in plants. Transcription factors (TFs) often act as regulatory hubs to regulate plant growth and responses to stress by integrating various biological pathways. Despite extensive studies on TFs functions in various plant species, our understanding of the details of TFs ...
Fang Liu, Nan Li, Zhu-Yun Yan, Xin Chen
openaire +1 more source
The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progression
, 2015 細胞ががん化する際には様々な代謝異常が生じるが、近年これらの代謝異常が、がん細胞の増殖や悪性化に深く関与していることが報告され、がん治療の新たな標的として注目を集めている。 我々は、がん抑制遺伝子RBの機能喪失が、脂質代謝経路、特にメバロン酸経路の多くの遺伝子発現を誘導することを見出した。また、その結果生じるコレステロールやその誘導体脂質が、細胞内ROSレベルを抑制することにより、がんの悪性化形質の獲得に寄与していることを明らかにした。 本研究は、RBによる脂質代謝制御という新たな機能と ...
40415170, 佐々木, 信成, 94670
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Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 10, Issue S1, June 2026.
wiley +1 more source
, 1998 It has recently been suggested that bisphosphonates may have direct antitumor effects in vivo, in addition to their therapeutic antiresorptive properties. Bisphosphonates can inhibit proliferation and cause apoptosis in human myeloma cells in vitro.
Croucher, PI +4 more
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Role of mevalonate pathway in the central nervous system
, 2017 La voie biosynthétique du mevalonate (MVA) est indispensable à la production de molécules qui sont essentielles dans grand nombre de processus physiologiques mais la plupart des études effectuées sur le rôle physiologique de cet important processus ...
Pallottini, Valentina
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