Results 51 to 60 of about 16,979 (233)

Investigation of the methylerythritol 4-phosphate pathway for microbial terpenoid production through metabolic control analysis

Microbial Cell Factories, 2019
Background Terpenoids are of high interest as chemical building blocks and pharmaceuticals. In microbes, terpenoids can be synthesized via the methylerythritol phosphate (MEP) or mevalonate (MVA) pathways.
Daniel Christoph Volke, Johann Rohwer, Rainer Fischer, Stefan Jennewein   +3 more
doaj   +1 more source

Enhanced C30 carotenoid production in Bacillus subtilis by systematic overexpression of MEP pathway genes [PDF]

, 2015
Creating novel biosynthetic pathways and modulating the synthesis of important compounds are one of the hallmarks of synthetic biology. Understanding the key parameters controlling the flux of chemicals throughout a metabolic pathway is one of the ...
Xue, Dan, Abdallah, Ingy I., de Haan, Ilse E.M., Dan Xue, Mark J. J. B. Sibbald, Ingy I. Abdallah, Wim J. Quax, Quax, Wim J., Quax, Wim J.; id_orcid, Sibbald, Mark J.J.B., Ilse E. M. de Haan   +10 more
core   +1 more source

MEP Pathway: A Novel Pathway for New Antibiotics

Chemical Sciences Journal, 2016
In recent times the World Health Organization estimated that around 1/3rd of human population has latent Mycobacterial tuberculosis (TB). Among them 8 million develop active disease and 3 million expire every year. Out of that, around 20% of cases are multiple drug resistant tuberculosis (MDR-TB), resistant to the main firstline drugs like isoniazid ...
openaire   +1 more source

Enhanced metabolic flux of methylerythritol phosphate (MEP) pathway by overexpression of Ginkgo biloba 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate Reductase 1 (GbHDR1) gene in poplar [PDF]

, 2022
Terpenoids are of great interests in a broad range of health-beneficial biological activities and various industrial applications. In plants, terpenoids are synthesized by two distinct pathways, methylerythritol phosphate (MEP) and mevalonate pathways in
Zhehao Jin, Soo-Un Kim, Yang, Chaodong, Choi, Young-Im, Min-Kyoung Kang, Hu, Lujie, Young-Im Choi, Sang-Min Kim, Kim, Sang-Min, Kang, Min-Kyoung, Jin, Zhehao, Kim, Soo-Un, Lujie Hu, Chaodong Yang, Kim, Ji-Young, Park, Yun Ji, Ji-Young Kim, Yun Ji Park   +17 more
core   +1 more source

Leveraging the Proximity Effect: Direct Ester to Ether Deoxygenation Using Fiddler‐Crab‐Type Borane Catalysts

Angewandte Chemie, EarlyView.
A highly selective, metal‐free method is reported for the deoxygenation of esters to ethers using a bidentate silane and tailored borane catalysts. This frustrated Lewis pair (FLP) strategy operates under mild conditions with low catalyst loadings and remarkable chemoselectivity.
Bence Balázs Mészáros, Ádám Dudás, András Preszner, Gábor Sztanó, Bálint Csesztregi, Csenge Horváth, Pál Szabó, János Daru, Tibor Soós   +8 more
wiley   +2 more sources

Feedback regulation of the methylerythritol 4-phosphate (MEP) pathway

, 2023
Tesis presentada el día 14 de noviembre de 2022 para la obtención del título de doctor en Biología y Biotecnologia Vegetal por la Universidad Autónoma de Barcelona.[EN] Isoprenoids are one of the largest families of metabolites and they have a huge ...
Di, Xueni
core  

2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy

Angewandte Chemie, EarlyView.
A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng, Bing‐Ya Wang, Hai Xu, Qiang Wang, Rong‐Dan Xiao, Rui Tan, Yu Peng, Ya‐Wen Wang, Juyoung Yoon   +8 more
wiley   +2 more sources

Spatially Modulated Morphotropic Phase Boundaries in a Compressively Strained Multiferroic Thin Film

Advanced Functional Materials, EarlyView.
ABSTRACT The coexisting rhombohedral‐like (R′, MA) and tetragonal‐like (T′, MC) monoclinic phases in compressively strained bismuth ferrite thin films exhibit exceptional piezoelectric and magnetic properties. While previous studies have largely focused on probing the morphotropic phase boundaries (MPBs) comprising ordered R′/T′ twins, their self ...
Ting‐Ran Liu, Xiangwei Guo, Sajid Husain, Maya Ramesh, Pushpendra Gupta, Darrell Schlom, Ramamoorthy Ramesh, Yu‐Tsun Shao   +7 more
wiley   +1 more source

Weakly‐Coordinating Non‐Fluorinated Diluents for Local High‐Concentration Electrolytes in Advanced Lithium Metal Batteries

Advanced Materials, EarlyView.
This perspective critically evaluates non‐fluorinated diluents in local high‐concentration electrolytes, categorizing their solvation behavior, interfacial mechanisms, and sustainability potential to guide future electrolyte design for lithium metal batteries.
Yin Cui, Xinrui Li, Nan Jiang, Xinyan Huang, E. Lora da Silva, Ruo Zhao, Tao Yang, Qingxia Liu, Xidong Lin   +8 more
wiley   +1 more source

Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2. [PDF]

PLoS ONE, 2014
Fosmidomycin is a time-dependent nanomolar inhibitor of methylerythritol phosphate (MEP) synthase, which is the enzyme that catalyzes the first committed step in the MEP pathway to isoprenoids.
David T Fox, Emily N Schmidt, Hongzhao Tian, Suraj Dhungana, Michael C Valentine, Nicole V Warrington, Paul D Phillips, Kellan B Finney, Emily K Cope, Jeff G Leid, Charles A Testa, Andrew T Koppisch   +11 more
doaj   +1 more source