Results 71 to 80 of about 16,979 (233)

Overexpression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase enhances the monoterpene content in Litsea cubeba

Forestry Research, 2023
Monoterpenes are important components of plant essential oils and have long been used as raw materials for spices and food flavorings. Litsea cubeba is an economically aromatic plant species, the fruits of which produce essential oil with monoterpenes as
Yunxiao Zhao, Yingguan Liu, Yicun Chen, Ming Gao, Liwen Wu, Yangdong Wang   +5 more
doaj   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

The methylerythritol phosphate pathway as an oxidative stress sense and response system

Nature Communications
The methylerythritol phosphate (MEP) pathway is responsible for biosynthesis of the precursors of isoprenoid compounds in eubacteria and plastids. It is a metabolic alternative to the well-known mevalonate pathway for isoprenoid production found in ...
Jordi Perez-Gil, James Behrendorff, Andrew Douw, Claudia E. Vickers   +3 more
doaj   +1 more source

Nickel‐Free Synthesis of Poly(pyrene‐4,5,9,10‐tetraone) for Sodium‐based Batteries: Insights into Electrode Architecture and Reversible Na‐ion Insertion

Advanced Energy Materials, EarlyView.
A nickel‐free and practical synthesis strategy to poly(pyrene tetraone) and its integration with a percolated CNTs/Ketjen Black network enables stable cycling and efficient energy storage in a sodium‐based batteries. This work demonstrates how controlling polymer structure and electrode architecture improves ion transport and mitigates dissolution in ...
Md. Adil, Robin Wessling, Nico Kokott, Elena Mena‐Osteritz, Benedikt Prifling, Markus Osenberg, Thomas Diemant, Volker Schmidt, Ingo Manke, Birgit Esser   +9 more
wiley   +1 more source

Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum

Memorias do Instituto Oswaldo Cruz, 2007
In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway.
María B Cassera, Emilio F Merino, Valnice J Peres, Emilia A Kimura, Gerhard Wunderlich, Alejandro M Katzin   +5 more
doaj  

Novel bioassay for the discovery of inhibitors of the 2-C-methyl-D-erythritol 4-phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis.

PLoS ONE, 2014
The 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway leads to the synthesis of isopentenyl diphosphate in plastids. It is a major branch point providing precursors for the synthesis of carotenoids, tocopherols, plastoquinone and the phytyl chain of ...
Natália Corniani, Edivaldo D Velini, Ferdinando M L Silva, N P Dhammika Nanayakkara, Matthias Witschel, Franck E Dayan   +5 more
doaj   +1 more source

Introduction of the Carotenoid Biosynthesis α-Branch Into Synechocystis sp. PCC 6803 for Lutein Production

Frontiers in Plant Science, 2021
Lutein, made by the α-branch of the methyl-erythritol phosphate (MEP) pathway, is one of the most abundant xanthophylls in plants. It is involved in the structural stabilization of light-harvesting complexes, transfer of excitation energy to chlorophylls
Martin Lehmann, Evgenia Vamvaka, Alejandro Torrado, Peter Jahns, Marcel Dann, Lea Rosenhammer, Amel Aziba, Dario Leister, Thilo Rühle   +8 more
doaj   +1 more source

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Isotope ratio-based quantification of carbon assimilation highlights the role of plastidial isoprenoid precursor availability in photosynthesis

Plant Methods, 2021
Background We report a method to estimate carbon assimilation based on isotope ratio-mass spectrometry (IRMS) of 13CO2 labeled plant tissue. Photosynthetic carbon assimilation is the principal experimental observable which integrates important aspects of
Matthew E. Bergman, Diego González-Cabanelas, Louwrance P. Wright, Berkley J. Walker, Michael A. Phillips   +4 more
doaj   +1 more source

Cloning, characterization, and expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene from Dioscorea zingiberensis

Biologia Plantarum, 2019
Diosgenin, mainly extracted from some Dioscorea species, is the most important starting material for the production of steroidal drugs. It is believed that diosgenin in Dioscorea is synthesized from isopentenyl diphosphate (IPP) and dimethylallyl ...
Z. Cheng, R. Wang, J. Shen, Z. Yang, Y. Chen   +4 more
doaj   +1 more source