Results 61 to 70 of about 3,014,380 (256)

Physical Activity Modulates Corticospinal Excitability of the Lower Limb in Young and Old Adults [PDF]

open access: yes, 2017
Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is ...
Hassanlouei, Hamidollah   +4 more
core   +3 more sources

Mutations in Escherichia coli aceE and ribB genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway. [PDF]

open access: yesPLoS ONE, 2012
A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria.
Jordi Perez-Gil   +9 more
doaj   +1 more source

Pain-motor integration in the primary motor cortex in Parkinson's disease [PDF]

open access: yes, 2017
In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through ...
Berardelli, Alfredo   +9 more
core   +1 more source

Engineering Production of a Novel Diterpene Synthase Precursor in Nicotiana benthamiana

open access: yesFrontiers in Plant Science, 2021
Diterpene biosynthesis commonly originates with the methylerythritol phosphate (MEP) pathway in chloroplasts, leading to the C20 substrate, geranylgeranyl pyrophosphate (GGPP).
Edith C. F. Forestier   +4 more
doaj   +1 more source

A comparative study of Gaussian Graphical Model approaches for genomic data [PDF]

open access: yes, 2011
The inference of networks of dependencies by Gaussian Graphical models on high-throughput data is an open issue in modern molecular biology. In this paper we provide a comparative study of three methods to obtain small sample and high dimension estimates
Ancona, N.   +5 more
core   +2 more sources

Unraveling the Mechanisms of Isoprenoid Biosynthetic Enzymes: Mechanistic Studies of the Early Stage Enzymes

open access: yesCHIMIA, 2009
Isoprenoids (or terpenoids) are a large and structurally diverse class of biomolecules that are essential for the survival of all forms of life.
Christopher J. Thibodeaux, Hung-wen Liu
doaj   +1 more source

Optimum conditions for regulating content change of secondary metabolites of Gentiana macrophylla by orthogonal method

open access: yesGuangxi Zhiwu, 2023
Gentiana macrophylla is a traditional Chinese herbal medicine for treating jaundice, hepatitis, and stomachic and choleretic ailments, and its main secondary metabolites are secoiridiod glycosides represented by gentiopicroside.
Huanhuan FU   +5 more
doaj   +1 more source

Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth. [PDF]

open access: yes, 2018
The ancient morphoregulatory hormone auxin dynamically realigns dedicated cellular processes that shape plant growth under prevailing environmental conditions. However, the nature of the stress-responsive signal altering auxin homeostasis remains elusive.
de Souza, Amancio   +9 more
core   +2 more sources

Investigation of the methylerythritol 4-phosphate pathway for microbial terpenoid production through metabolic control analysis

open access: yesMicrobial Cell Factories, 2019
Background Terpenoids are of high interest as chemical building blocks and pharmaceuticals. In microbes, terpenoids can be synthesized via the methylerythritol phosphate (MEP) or mevalonate (MVA) pathways.
Daniel Christoph Volke   +3 more
doaj   +1 more source

Mapping the cortical representation of the lumbar paravertebral muscles [PDF]

open access: yes, 2007
Objective: The aim of this study was to map the cortical representation of the lumbar spine paravertebral (LP) muscles in healthy subjects. Methods: Transcranial magnetic stimulation (TMS) was employed to map the cortical representations of the LP ...
A.V. Nowicky   +32 more
core   +1 more source

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