Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective [PDF]
Frontiers in Chemistry, 2021 Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster class of drugs nitrogen-containing bisphosphonates represent one of the best-known
Jaeok Park +3 more
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Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product [PDF]
Nature Communications, 2017 Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is an ...
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Correction: Farnesyl pyrophosphate is a new danger signal inducing acute cell death [PDF]
PLoS Biology, 2023 [This corrects the article DOI: 10.1371/journal.pbio.3001134.].
Jing Chen +13 more
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Cwh8 moonlights as a farnesyl pyrophosphate phosphatase and is essential for farnesol biosynthesis in Candida albicans [PDF]
mBioIn the opportunistic pathogen Candida albicans, hyphal growth and virulence factor expression are regulated by environmental and chemical cues. Farnesol is a secreted autoregulatory molecule that represses filamentation.
Daniel J. Gutzmann +7 more
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Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase [PDF]
FEBS Open BioMevalonate kinase is a key regulator of the mevalonate pathway, subject to feedback inhibition by the downstream metabolite farnesyl pyrophosphate. In this study, we validated the hypothesis that monophosphonate compounds mimicking farnesyl pyrophosphate
Saman Salari +3 more
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Farnesyl pyrophosphate is a new danger signal inducing acute cell death. [PDF]
PLoS Biology, 2021 Cell death is a vital event in life. Infections and injuries cause lytic cell death, which gives rise to danger signals that can further induce cell death, inflammation, and tissue damage.
Jing Chen +13 more
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Inhibition of farnesyl pyrophosphate synthase alleviates cardiomyopathy in diabetic rat. [PDF]
Cell Cycle, 2023 This study investigated the effects of ibandronate (IBN) on cardiomyopathy remodeling in diabetic rats. A rat model of diabetic cardiomyopathy (DCM) was established by supplementing them with a high-calorie diet combined with a low dose of streptozotocin (STZ).
Liu X, Liu Y, Tang L, Du C.
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Reaction mechanism of the farnesyl pyrophosphate C-methyltransferase towards the biosynthesis of pre-sodorifen pyrophosphate by Serratia plymuthica 4Rx13 [PDF]
Scientific Reports, 2021 Classical terpenoid biosynthesis involves the cyclization of the linear prenyl pyrophosphate precursors geranyl-, farnesyl-, or geranylgeranyl pyrophosphate (GPP, FPP, GGPP) and their isomers, to produce a huge number of natural compounds.
Marie Chantal Lemfack +10 more
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The Property of a Key Amino Acid Determines the Function of Farnesyl Pyrophosphate Synthase in Sporobolomyces pararoseus NGR [PDF]
Current Issues in Molecular BiologyFarnesyl pyrophosphate synthase (FPPS) catalyzes the synthesis of C15 farnesyl diphosphate (FPP) from C5 dimethylallyl diphosphate (DMAPP) and two or three C5 isopentenyl diphosphates (IPPs). FPP is an important precursor for the synthesis of isoprenoids
Yunjiao Wang +8 more
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Systematic characterization and functional analysis of trans-prenyltransferases in Curcuma wenyujin [PDF]
Frontiers in Plant ScienceIntroductionCurcuma wenyujin (Zingiberaceae), a medicinally significant species within the Curcuma genus, is highly regarded in traditional Chinese medicine for its rich terpenoid constituents.
Qian Wang +14 more
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