Results 1 to 10 of about 296 (134)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

Frontiers in Chemistry, 2021
Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster class of drugs nitrogen-containing bisphosphonates represent one of the best-known
Albert Berghuis, Jaeok Park, Berghuis Albert M   +2 more
exaly   +3 more sources

Computational study of the inhibitory potential of Gongronema latifolium (benth) leave on farnesyl pyrophosphate synthase, a target enzyme in the treatment of osteoporosis. A molecular modelling approach

Journal of Herbal Drugs, 2022
Background & Aim: Osteoporosis is an increasing medical threat which is referred to as a systemic skeletal disorder that is characterized mainly by low bone mass and microarchitectural wear of bone tissue and strength, which eventually results in an ...
Samuel O. Olubode, Bankole Mutolib , Precious Ayorinde Akinnusi , Wasiu A. Salaudeen , Kehinde I. Ojubola, Olayinka S. Adanlawo, Abigail Oluwakemi Ayodele , Adefunke O. Ogunlade, Abdullahi A. Aderemi   +8 more
doaj   +1 more source

Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice

Rice Science, 2021
Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao, Lou Lijuan, Li Zeyu, Shang Lianguang, Wang Quan   +4 more
doaj   +1 more source

Regulation of Fatty Acid Synthesis by Farnesyl Pyrophosphate [PDF]

Journal of Biological Chemistry, 2005
Fatty acid biosynthesis is transcriptionally regulated by liver X receptor (LXR) and its gene target, sterol regulatory element binding protein-1c (SREBP-1c). LXR activation is induced by oxysterol end products of the mevalonate pathway and is inhibited by the upstream non-sterol isoprenoid, geranylgeranyl pyrophosphate (GGPP). Whether isoprenoids play
Shubha, Murthy, Huaxiang, Tong, Raymond J, Hohl   +2 more
openaire   +2 more sources

Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase

Nature Communications, 2023
Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates substrate promiscuity by accepting geranyl pyrophosphate and farnesyl pyrophosphate ...
Zhong Li, Lilan Zhang, Kangwei Xu, Yuanyuan Jiang, Jieke Du, Xingwang Zhang, Ling-Hong Meng, Qile Wu, Lei Du, Xiaoju Li, Yuechan Hu, Zhenzhen Xie, Xukai Jiang, Ya-Jie Tang, Ruibo Wu, Rey-Ting Guo, Shengying Li   +16 more
doaj   +1 more source

Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate

Journal of Lipid Research, 1969
Several mechanisms that utilize farnesyl pyrophosphate and nerolidyl pyrophosphate as condensing substrates have been postulated for the asymmetric condensation reaction in squalene biosynthesis.
S.S. Sofer, H.C. Rilling
doaj   +1 more source

Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta

Journal of Lipid Research, 1973
Homogenates and subcellular fractions of the intima–media of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene.
Linda L. Slakey, Gene C. Ness, Nilofer Qureshi, John W. Porter   +3 more
doaj   +1 more source

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments

Cells, 2020
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.
Nguyen Thi Ha, Chang Hoon Lee
doaj   +1 more source

Sites of control of hepatic cholesterol biosynthesis

Journal of Lipid Research, 1966
An inhibition in the conversion of mevalonate to cholesterol has been demonstrated in liver of cholesterol-fed rats by both in vitro and in vivo methods.
R. Gordon Gould, E.A. Swyryd
doaj   +1 more source

Biosynthesis of presqualene pyrophosphate by liver microsomes

Journal of Lipid Research, 1970
Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been ...
H.C. RILLING
doaj   +1 more source