Results 11 to 20 of about 15,452 (211)

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells [PDF]

BMC Cardiovascular Disorders
Background Nitrogen-containing bisphosphonate(N-BP)had been found to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells (VSMCs), but the mechanism is not clear.
Wei Xu, Lifeng Gong, Weigang Tang, Guoyuan Lu   +3 more
doaj   +2 more sources

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii. [PDF]

PLoS ONE, 2015
Farnesylpyrophosphate synthase (FPS) catalyzes the biosynthesis of farnesyl pyrophosphate (FPP), which is an important precursor of sesquiterpenoids such as artemisinin and wilfordine.
Yu-Jun Zhao, Xin Chen, Meng Zhang, Ping Su, Yu-Jia Liu, Yu-Ru Tong, Xiu-Juan Wang, Lu-Qi Huang, Wei Gao   +8 more
doaj   +2 more sources

Computational study of the inhibitory potential of Gongronema latifolium (benth) leave on farnesyl pyrophosphate synthase, a target enzyme in the treatment of osteoporosis. A molecular modelling approach

Journal of Herbal Drugs, 2022
Background & Aim: Osteoporosis is an increasing medical threat which is referred to as a systemic skeletal disorder that is characterized mainly by low bone mass and microarchitectural wear of bone tissue and strength, which eventually results in an ...
Samuel O. Olubode, Bankole Mutolib , Precious Ayorinde Akinnusi , Wasiu A. Salaudeen , Kehinde I. Ojubola, Olayinka S. Adanlawo, Abigail Oluwakemi Ayodele , Adefunke O. Ogunlade, Abdullahi A. Aderemi   +8 more
doaj   +1 more source

Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice

Rice Science, 2021
Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao, Lou Lijuan, Li Zeyu, Shang Lianguang, Wang Quan   +4 more
doaj   +1 more source

Regulation of Fatty Acid Synthesis by Farnesyl Pyrophosphate [PDF]

Journal of Biological Chemistry, 2005
Fatty acid biosynthesis is transcriptionally regulated by liver X receptor (LXR) and its gene target, sterol regulatory element binding protein-1c (SREBP-1c). LXR activation is induced by oxysterol end products of the mevalonate pathway and is inhibited by the upstream non-sterol isoprenoid, geranylgeranyl pyrophosphate (GGPP). Whether isoprenoids play
Shubha, Murthy, Huaxiang, Tong, Raymond J, Hohl   +2 more
openaire   +2 more sources

Metabolic origins and transport of vitamin e biosynthetic precursors [PDF]

, 2017
Tocochromanols are organic compounds mostly produced by photosynthetic organisms that exhibit vitamin E activity in animals. They result from the condensation of homogentisate with four different polyprenyl side chains derived all from geranylgeranyl ...
Mène-Saffrané, Laurent, Pellaud, Sébastien   +1 more
core   +8 more sources

Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase

Nature Communications, 2023
Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates substrate promiscuity by accepting geranyl pyrophosphate and farnesyl pyrophosphate ...
Zhong Li, Lilan Zhang, Kangwei Xu, Yuanyuan Jiang, Jieke Du, Xingwang Zhang, Ling-Hong Meng, Qile Wu, Lei Du, Xiaoju Li, Yuechan Hu, Zhenzhen Xie, Xukai Jiang, Ya-Jie Tang, Ruibo Wu, Rey-Ting Guo, Shengying Li   +16 more
doaj   +1 more source

Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate

Journal of Lipid Research, 1969
Several mechanisms that utilize farnesyl pyrophosphate and nerolidyl pyrophosphate as condensing substrates have been postulated for the asymmetric condensation reaction in squalene biosynthesis.
S.S. Sofer, H.C. Rilling
doaj   +1 more source

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta

Journal of Lipid Research, 1973
Homogenates and subcellular fractions of the intima–media of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene.
Linda L. Slakey, Gene C. Ness, Nilofer Qureshi, John W. Porter   +3 more
doaj   +1 more source