Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii. [PDF]
PLoS ONE, 2015 Farnesylpyrophosphate synthase (FPS) catalyzes the biosynthesis of farnesyl pyrophosphate (FPP), which is an important precursor of sesquiterpenoids such as artemisinin and wilfordine.
Yu-Jun Zhao +8 more
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Computational study of the inhibitory potential of Gongronema latifolium (benth) leave on farnesyl pyrophosphate synthase, a target enzyme in the treatment of osteoporosis. A molecular modelling approach [PDF]
Journal of Herbal Drugs, 2022 Background & Aim: Osteoporosis is an increasing medical threat which is referred to as a systemic skeletal disorder that is characterized mainly by low bone mass and microarchitectural wear of bone tissue and strength, which eventually results in an ...
Samuel O. Olubode +8 more
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Effects of Farnesyl Pyrophosphate Accumulation on Calvarial Osteoblast Differentiation [PDF]
Endocrinology, 2011 Statins, drugs commonly used to lower serum cholesterol, have been shown to stimulate osteoblast differentiation and bone formation. Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and ...
Megan M, Weivoda, Raymond J, Hohl
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Journal of Integrative Agriculture, 2020 Sesquiterpenoids play an import role in the direct or indirect defense of plants. Farnesyl pyrophosphate synthases (FPSs) catalyze the biosynthesis of farnesyl pyrophosphate, which is a key precursor of farnesol and (E)-β-farnesene. In the current study,
Hong ZHANG +6 more
doaj +2 more sources
Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
Cells, 2020 Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.
Nguyen Thi Ha, Chang Hoon Lee
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Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist [PDF]
Biochemical Journal, 2011 The cholesterol biosynthetic pathway produces not only sterols but also non-sterol mevalonate metabolites involved in isoprenoid synthesis. Mevalonate metabolites affect transcriptional and post-transcriptional events that in turn affect various biological processes including energy metabolism.
Goto, Tsuyoshi +12 more
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Farnesyl pyrophosphate compartmentalization in the green microalga Chlamydomonas reinhardtii during heterologous (E)-α-bisabolene production. [PDF]
Microb Cell Fact, 2022 Wichmann J, Eggert A, Elbourne LDH, Paulsen IT, Lauersen KJ, Kruse O. Farnesyl pyrophosphate compartmentalization in the green microalga Chlamydomonasreinhardtii during heterologous (E)-alpha-bisabolene production. Microbial Cell Factories.
Wichmann J +5 more
europepmc +2 more sources
Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors. [PDF]
PLoS ONE, 2014 The yeast Xanthophyllomyces dendrorhous synthesizes the carotenoid astaxanthin, which has applications in biotechnology because of its antioxidant and pigmentation properties.
Jennifer Alcaíno +6 more
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Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. [PDF]
PLoS One, 2017 Human farnesyl pyrophosphate synthase (hFPPS) catalyzes the production of the 15-carbon isoprenoid farnesyl pyrophosphate. The enzyme is a key regulator of the mevalonate pathway and a well-established drug target.
Park J +5 more
europepmc +2 more sources
Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice
Rice Science, 2021 Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao +4 more
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