Results 11 to 20 of about 296 (134)

Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. [PDF]

PLoS ONE, 2013
In vitro synthesis of chemicals and pharmaceuticals using enzymes is of considerable interest as these biocatalysts facilitate a wide variety of reactions under mild conditions with excellent regio-, chemo- and stereoselectivities.
Xixian Chen, Congqiang Zhang, Ruiyang Zou, Kang Zhou, Gregory Stephanopoulos, Heng Phon Too   +5 more
doaj   +1 more source

Effect of detergents on sterol synthesis in a cell-free system of yeast

Journal of Lipid Research, 1982
In order to obtain information about the reactivity of enzymes in sterol synthesis of yeast, the effects of some detergents were investigated. Among the detergents used, Triton X-100 was found to exert a unique action, and its effect on the incorporation
S Hata, T Nishino, N Ariga, H Katsuki
doaj   +1 more source

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

Nature Communications, 2017
Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is an ...
Jaeok Park, Michal Zielinski, Alexandr Magder, Youla S. Tsantrizos, Albert M. Berghuis   +4 more
doaj   +1 more source

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl

AMB Express, 2022
Dendrobium nobile Lindl. has been used as a traditional Chinese medicine for a long time, in which the most important compound is dendrobine functioning in a variety of pharmacological activities.
Daoyong Gong, Bin Wu, Hongting Qin, Dezhao Fu, Shunxing Guo, Bochu Wang, Biao Li   +6 more
doaj   +1 more source

Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase [PDF]

Current Medicinal Chemistry, 2011
Bisphosphonates (BPs) are the most widely used and effective treatment for osteoporosis and Paget's disease. Non-nitrogen containing BPs (non-N-BPs), namely etidronate, clodronate, tiludronate, as well as nitrogen containing BPs (N-BPs), namely pamidronate, alendronate, ibandronate, risedronate, zoledronate and minodronate have been launched on the ...
Ohno, K, Mori, K, Orita, M, Takeuchi, M
openaire   +2 more sources

Targeting of Mevalonate-Isoprenoid Pathway in Acute Myeloid Leukemia Cells by Bisphosphonate Drugs

Biomedicines, 2022
Metabolic reprogramming represents a hallmark of tumorigenesis to sustain survival in harsh conditions, rapid growth and metastasis in order to resist to cancer therapies.
Emanuela Chiarella, Clelia Nisticò, Anna Di Vito, Helen Linda Morrone, Maria Mesuraca   +4 more
doaj   +1 more source

Effects of Farnesyl Pyrophosphate Accumulation on Calvarial Osteoblast Differentiation [PDF]

Endocrinology, 2011
Statins, drugs commonly used to lower serum cholesterol, have been shown to stimulate osteoblast differentiation and bone formation. Statins inhibit 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (HMGCR), the first step of the isoprenoid biosynthetic pathway, leading to the depletion of the isoprenoids farnesyl pyrophosphate (FPP) and ...
Megan M, Weivoda, Raymond J, Hohl
openaire   +2 more sources

Metabolic Labeling and Visualization of Isoprenoids Using Alkyne‐Modified DMAPP Analogs in Bacillus subtilis

Angewandte Chemie, EarlyView.
Fluorescence‐based visualization and targeted mass–spectrometric enrichment of membrane‐embedded isoprenoids in Bacillus subtilis via cell‐permeant, alkynylated DMAPP analogs. ABSTRACT Isoprenoids are a chemically and functionally diverse class of metabolites that underlie essential bacterial physiology including respiration and cell envelope ...
Zackary N. Hulsey, Dillon P. McBee, Claudia L. Dolan, Francis M. Rossi, Neil A. Truslow, Allyson R. Taylor, Thomas N. Trybala, Joshua A. Baccile   +7 more
wiley   +2 more sources

Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures

Angewandte Chemie, EarlyView.
Our synthetic endeavor toward the total synthesis of the reported unprecedented tricyclic skeleton of the sesquiterpene pestalustaine A allowed us to perform divergent cyclizations of a bicyclo[4.4.1]undec‐3‐ene into complex tricyclic architectures and to revise the structure of the natural product.
Wei Cao, Alicia Ross, Jean‐Pierre Baltaze, Régis Guillot, Menglin Xu, Rongzhen Qin, Bingcheng Yang, Isabel Wong, Katayoon Formul, Cyrille Kouklovsky, Dean J. Tantillo, Vincent Gandon, Guillaume Vincent   +12 more
wiley   +2 more sources

Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS

Molecules, 2018
Isoprenoids (IsoP) are an important class of molecules involved in many different cellular processes including cholesterol synthesis. We have developed a sensitive and specific LC-MS/MS method for the quantitation of three key IsoPs in bio-matrices ...
Yashpal S. Chhonker, Staci L. Haney, Veenu Bala, Sarah A. Holstein, Daryl J. Murry   +4 more
doaj   +1 more source