Results 1 to 10 of about 621 (94)

Lipopolysaccharide Is a 4-Aminoarabinose Donor to Exogenous Polyisoprenyl Phosphates through the Reverse Reaction of the Enzyme ArnT [PDF]

ACS Omega, 2021
Modification of the lipid A portion of LPS with cationic monosaccharides provides resistance to polymyxins, which are often employed as a last resort to treat multidrug-resistant bacterial infections. Here, we describe the use of fluorescent polyisoprenoids, liquid chromatography-mass spectrometry, and bacterial genetics to probe the activity of ...
Jerry Troutman
exaly   +6 more sources

Regulation of phosphatidylinositol 3–kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury [PDF]

Journal of Experimental Medicine, 2006
Neutrophils play a central role in host defense, inflammation, and tissue injury. Recent findings indicate a novel role for polyisoprenyl phosphates (PIPPs) as natural down-regulatory signals in neutrophils. The relationship between PIPPs and neutrophil early activating signals, such as phosphoinositides, has not been previously determined.
Bruce David Levy, Nicos Petasis, Levy Bruce D   +2 more
exaly   +8 more sources

Polyisoprenyl phosphates: natural antiinflammatory lipid signals [PDF]

Cellular and Molecular Life Sciences, 2002
Lipoxins (LX) and aspirin-triggered 15-epimer LX are leukocyte-derived eicosanoids generated during host defense that serve as down-regulatory signals. The specific intracellular events that govern cellular responses to inhibitory extracellular signals are of wide interest in order to understand pivotal intracellular events in diseases characterized by
Bruce David Levy, Charles N Serhan, C N Serhan   +2 more
exaly   +4 more sources

Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo [PDF]

British Journal of Pharmacology, 2005
Leukocyte production of reactive oxygen species (ROS) is an essential component of the antimicrobial armament mounted during host defense, but when released to the extracellular milieu ROS can also injure host tissues and provoke inflammation. Polyisoprenyl phosphates (PIPPs) are constituents of human leukocyte membranes that regulate pivotal ...
Gérard Bannenberg, Bruce David Levy, Nicos Petasis   +2 more
exaly   +5 more sources

Structural insights into polyisoprenyl-binding glycosyltransferases [PDF]

Structure
Filippo Mancia, Ryan Morgan
exaly   +2 more sources

Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization

iScience, 2022
Summary: Lipid phosphate phosphatases are a family of enzymes with diverse cellular metabolic functions. Phospholipid phosphatase 6 (PLPP6) is a regulator of cellular polyisoprenyl phosphates; however, its in vivo functions remain to be determined. Here,
Thayse R. Brüggemann, Troy Carlo, Nandini Krishnamoorthy, Melody G. Duvall, Raja-Elie E. Abdulnour, Julie Nijmeh, Hong Yong Peh, Harilaos Filippakis, Roxanne H. Croze, Byoungsook Goh, Sungwhan F. Oh, Bruce D. Levy   +11 more
doaj   +1 more source

The two‐component system CroRS acts as a master regulator of cell envelope homeostasis to confer antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis

Molecular Microbiology, Volume 120, Issue 3, Page 408-424, September 2023., 2023
In Enterococcus faecalis, CroRS regulates the expression of cell envelope biosynthesis pathways to maintain homeostasis and confer tolerance upon antimicrobial challenge. Loss of function mutations in the respiratory branch of the isoprenoid pathway appears to rescue tolerance in a croRS deletion mutant.
Francesca O. Todd Rose, Rachel L. Darnell, Sali M. Morris, Olivia E. Rose, Olivia Paxie, Georgia Campbell, Gregory M. Cook, Susanne Gebhard   +7 more
wiley   +1 more source

New insights into natural rubber biosynthesis from rubber‐deficient lettuce mutants expressing goldenrod or guayule cis‐prenyltransferase

New Phytologist, Volume 239, Issue 3, Page 1098-1111, August 2023., 2023
Summary Lettuce produces natural rubber (NR) with an average Mw of > 1 million Da in laticifers, similar to NR from rubber trees. As lettuce is an annual, self‐pollinating, and easily transformable plant, it is an excellent model for molecular genetic studies of NR biosynthesis.
Moonhyuk Kwon, Connor L. Hodgins, Eman M. Salama, Kayla R. Dias, Aalap Parikh, Ashlyn V. Mackey, Karizza F. Catenza, John C. Vederas, Dae‐Kyun Ro   +8 more
wiley   +1 more source

Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors

ChemMedChem, Volume 16, Issue 24, Page 3730-3738, December 14, 2021., 2021
Precision nanomedicines can improve osteosarcoma treatments by enhancing the action of cytostatic agents through selective targeting to the bone tumor area. HbisP−Sq, a lipid molecule with high affinity for calcium ions present in HA has been successfully synthetized.
Carlos Rodríguez‐Nogales, Didier Desmaële, Víctor Sebastián, Patrick Couvreur, María J. Blanco‐Prieto   +4 more
wiley   +1 more source

Identification of the Wzx flippase, Wzy polymerase and sugar‐modifying enzymes for spore coat polysaccharide biosynthesis in Myxococcus xanthus

Molecular Microbiology, Volume 113, Issue 6, Page 1189-1208, June 2020., 2020
Myxococcus xanthus differentiates to environmentally resistant spores in response to various stresses. Resistance is provided by the spore coat polysaccharide that is synthesised by the ExoA‐I proteins, which make up an incomplete Wzx/Wzy pathway for polysaccharide synthesis and export. Here, we identified the Wzx flippase and Wzy polymerase as well as
María Pérez‐Burgos, Inmaculada García‐Romero, Miguel A. Valvano, Lotte Søgaard Andersen   +3 more
wiley   +1 more source