Results 1 to 10 of about 712 (131)

Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo. [PDF]

Br J Pharmacol, 2005
Leukocyte production of reactive oxygen species (ROS) is an essential component of the antimicrobial armament mounted during host defense, but when released to the extracellular milieu ROS can also injure host tissues and provoke inflammation. Polyisoprenyl phosphates (PIPPs) are constituents of human leukocyte membranes that regulate pivotal ...
Levy BD, Hickey L, Morris AJ, Larvie M, Keledjian R, Petasis NA, Bannenberg G, Serhan CN.   +7 more
europepmc   +9 more sources

Lipopolysaccharide Is a 4‑Aminoarabinose Donor to Exogenous Polyisoprenyl Phosphates through the Reverse Reaction of the Enzyme ArnT [PDF]

ACS Omega, 2021
Modification of the lipid A portion of LPS with cationic monosaccharides provides resistance to polymyxins, which are often employed as a last resort to treat multidrug-resistant bacterial infections. Here, we describe the use of fluorescent polyisoprenoids, liquid chromatography-mass spectrometry, and bacterial genetics to probe the activity of ...
Beth A. Scarbrough, Colleen R. Eade, Amanda J. Reid, Tiffany C. Williams, Jerry M. Troutman   +4 more
doaj   +5 more sources

Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury. [PDF]

J Exp Med, 2006
Neutrophils play a central role in host defense, inflammation, and tissue injury. Recent findings indicate a novel role for polyisoprenyl phosphates (PIPPs) as natural down-regulatory signals in neutrophils. The relationship between PIPPs and neutrophil early activating signals, such as phosphoinositides, has not been previously determined.
Bonnans C, Fukunaga K, Keledjian R, Petasis NA, Levy BD.   +4 more
europepmc   +9 more sources

Polyisoprenyl phosphates: natural antiinflammatory lipid signals. [PDF]

Cell Mol Life Sci, 2002
Lipoxins (LX) and aspirin-triggered 15-epimer LX are leukocyte-derived eicosanoids generated during host defense that serve as down-regulatory signals. The specific intracellular events that govern cellular responses to inhibitory extracellular signals are of wide interest in order to understand pivotal intracellular events in diseases characterized by
Levy BD, Serhan CN.
europepmc   +5 more sources

Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis [PDF]

Nature Communications, 2016
Abstract The attachment of a sugar to a hydrophobic polyisoprenyl carrier is the first step for all extracellular glycosylation processes. The enzymes that perform these reactions, polyisoprenyl-glycosyltransferases (PI-GTs) include dolichol phosphate mannose synthase (DPMS), which generates the mannose donor for ...
Ardiccioni, Chiara, Clarke, Oliver B, Tomasek, David, Issa, Habon A, von Alpen, Desiree C, Pond, Heather L, Banerjee, Surajit, Rajashankar, Kanagalaghatta R, Liu, Qun, Guan, Ziqiang, Li, Chijun, Kloss, Brian, Bruni, Renato, Kloppmann, Edda, Rost, Burkhard, Manzini, M Chiara, Shapiro, Lawrence, Mancia, Filippo   +17 more
core   +9 more sources

Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria. [PDF]

Nat Commun
In Gram-negative bacteria, the enzymatic modification of Lipid A with aminoarabinose (L-Ara4N) leads to resistance against polymyxin antibiotics and cationic antimicrobial peptides.
Ashraf KU, Bunoro-Batista M, Ansell TB, Punetha A, Rosario-Garrido S, Firlar E, Kaelber JT, Stansfeld PJ, Petrou VI.   +8 more
europepmc   +3 more sources

Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization

iScience, 2022
Summary: Lipid phosphate phosphatases are a family of enzymes with diverse cellular metabolic functions. Phospholipid phosphatase 6 (PLPP6) is a regulator of cellular polyisoprenyl phosphates; however, its in vivo functions remain to be determined. Here,
Thayse R. Brüggemann, Troy Carlo, Nandini Krishnamoorthy, Melody G. Duvall, Raja-Elie E. Abdulnour, Julie Nijmeh, Hong Yong Peh, Harilaos Filippakis, Roxanne H. Croze, Byoungsook Goh, Sungwhan F. Oh, Bruce D. Levy   +11 more
doaj   +1 more source

Polyisoprenyl phosphate specificity of UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli [PDF]

Glycobiology, 1997
N-Acetyl-D-glucosaminylpyrophosphorylundecaprenol (GlcNAc-P-P-Und), an intermediate in the biosynthesis of the enterobacterial common antigen in E.coli and some O-antigen chains in gram-negative bacteria, is formed by the transfer of GlcNAc 1-P from UDP-GlcNAc to Und-P, analogous to the reaction forming GlcNAc-P-P-dolichol (GlcNAc-P-P-Dol) in mammalian
J S, Rush, P D, Rick, C J, Waechter
openaire   +2 more sources

Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy? [PDF]

, 2021
Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management.
Bermúdez, Valmore, Chávez-Castillo, Mervin, Cudris-Torres, Lorena, De Sanctis, Juan B., Duran, Pablo, Garrido, Bermary, Manzano, Alexander, Ortega, Ángel, Rojas, Milagros, Rojas-Gomez, Diana Marcela, Salazar, Juan, Silva, Aljadis   +11 more
core   +1 more source

Characterization of the highly conserved VFMGD motif in a bacterial polyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferase [PDF]

Protein Science, 2012
AbstractPolyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferases (PNPTs) constitute a family of eukaryotic and prokaryotic membrane proteins that catalyze the transfer of a sugar‐1‐phosphate to a phosphoisoprenyl lipid carrier. All PNPT members share a highly conserved 213‐Valine‐Phenylalanine‐Methionine‐Glycine‐Aspartic acid‐217 (VFMGD ...
Furlong, Sarah E, Valvano, Miguel A
openaire   +3 more sources