Results 11 to 20 of about 712 (131)

Determination of the anomeric configuration of glycosyl esters of nucleoside pyrophosphates and polyisoprenyl phosphates by fast-atom bombardment tandem mass spectrometry [PDF]

Journal of the American Society for Mass Spectrometry, 1996
Collision-induced dissociation of the deprotonated molecules of glycosyl esters of nucleoside pyrophosphates and polyisoprenyl (dolichyl and polyprenyl) phosphates results in distinct fragmentation patterns that depend on cis-trans configuration of the phosphodiester and 2″ (or 2', respectively)-hydroxyl groups of the glycosyl residue. At the collision-
Wolucka, Beata A., de Hoffmann, Edmond, Rush, Jeffrey S., Waechter, Charles J.   +3 more
openaire   +4 more sources

The synthesis and chemical properties of polyisoprenyl beta-D-mannopyranosyl phosphates.

Journal of Biological Chemistry, 1975
2,3,4,6-Tetra-O-acetyl-beta-D-mannopyranosyl phosphate, free of the alpha anomer, was coupled with citronellol and dolichol in the presence of triisopropylbenzenesulfonyl chloride to give, after chromatographic purification and deacetylation, the respective polyisoprenyl beta-D-mannopyranosyl phosphates.
C D, Warren, I Y, Liu, A, Herscovics, R W, Jeanloz   +3 more
openaire   +4 more sources

Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer’s Disease [PDF]

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
This review is focused on the possible causes of mitochondrial dysfunction in AD, underlying molecular mechanisms of this malfunction, possible causes and known consequences of APP, Aβ, and hyperphosphorylated tau presence in mitochondria, and the ...
Arkadiusz Orzechowski, Beata Pająk, Elżbieta Kania   +2 more
core   +3 more sources

The two‐component system CroRS acts as a master regulator of cell envelope homeostasis to confer antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis

Molecular Microbiology, Volume 120, Issue 3, Page 408-424, September 2023., 2023
In Enterococcus faecalis, CroRS regulates the expression of cell envelope biosynthesis pathways to maintain homeostasis and confer tolerance upon antimicrobial challenge. Loss of function mutations in the respiratory branch of the isoprenoid pathway appears to rescue tolerance in a croRS deletion mutant.
Francesca O. Todd Rose, Rachel L. Darnell, Sali M. Morris, Olivia E. Rose, Olivia Paxie, Georgia Campbell, Gregory M. Cook, Susanne Gebhard   +7 more
wiley   +1 more source

New insights into natural rubber biosynthesis from rubber‐deficient lettuce mutants expressing goldenrod or guayule cis‐prenyltransferase

New Phytologist, Volume 239, Issue 3, Page 1098-1111, August 2023., 2023
Summary Lettuce produces natural rubber (NR) with an average Mw of > 1 million Da in laticifers, similar to NR from rubber trees. As lettuce is an annual, self‐pollinating, and easily transformable plant, it is an excellent model for molecular genetic studies of NR biosynthesis.
Moonhyuk Kwon, Connor L. Hodgins, Eman M. Salama, Kayla R. Dias, Aalap Parikh, Ashlyn V. Mackey, Karizza F. Catenza, John C. Vederas, Dae‐Kyun Ro   +8 more
wiley   +1 more source

Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors

ChemMedChem, Volume 16, Issue 24, Page 3730-3738, December 14, 2021., 2021
Precision nanomedicines can improve osteosarcoma treatments by enhancing the action of cytostatic agents through selective targeting to the bone tumor area. HbisP−Sq, a lipid molecule with high affinity for calcium ions present in HA has been successfully synthetized.
Carlos Rodríguez‐Nogales, Didier Desmaële, Víctor Sebastián, Patrick Couvreur, María J. Blanco‐Prieto   +4 more
wiley   +1 more source

Structural insights into polyisoprenyl-binding glycosyltransferases. [PDF]

Structure
Zinkle AP, Morgan RT, Nygaard R, Mancia F.   +3 more
europepmc   +2 more sources

Identification of the Wzx flippase, Wzy polymerase and sugar‐modifying enzymes for spore coat polysaccharide biosynthesis in Myxococcus xanthus

Molecular Microbiology, Volume 113, Issue 6, Page 1189-1208, June 2020., 2020
Myxococcus xanthus differentiates to environmentally resistant spores in response to various stresses. Resistance is provided by the spore coat polysaccharide that is synthesised by the ExoA‐I proteins, which make up an incomplete Wzx/Wzy pathway for polysaccharide synthesis and export. Here, we identified the Wzx flippase and Wzy polymerase as well as
María Pérez‐Burgos, Inmaculada García‐Romero, Miguel A. Valvano, Lotte Søgaard Andersen   +3 more
wiley   +1 more source

A widespread family of bacterial cell wall assembly proteins [PDF]

, 2011
Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and ...
Adams, Atilano, Bhavsar, Bouhss, Brown, Brunskill, Bunkoczi, Carballido-Lopez, Christopher N Hoyland, Cieslewicz, Claessen, Cleland, Daniel, D‧Elia, D‧Elia, D‧Elia, Emsley, Evans, Figge, Formstone, Formstone, Foster, Glaser, Graumann, Hanson, Harwood, Henriques, Hu, Hübscher, Hübscher, Ishikawa, Jeff Errington, Jon Marles-Wright, Jones, Kawai, Kawai, Kruse, Kuwana, Langer, Lassila, Latge, Lazarevic, Lazarevic, Leaver, Leslie, Masayoshi Kuwano, Massidda, McNeil, Morona, Nadja Heinz, Naotake Ogasawara, Neuhaus, Nhat Khai Bui, Pape, Richard A Daniel, Richard J Lewis, Robert M Cleverley, Robyn Emmins, Scheffers, Schirner, Schirner, Sheldrick, Shu Ishikawa, Slovak, Soldo, Strahl, Swoboda, Swoboda, Tomasz, Vats, Waldemar Vollmer, Wei, Weidenmaier, Wolters, Wu, Yokoyama, Yoshikazu Kawai, Young   +77 more
core   +1 more source

Structure analysis of biologically important prokaryotic glycopolymers [PDF]

, 2013
Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria, Ventura, Valeria Victoria   +1 more
core   +1 more source