Results 11 to 20 of about 763,041 (124)

Characterization of the highly conserved VFMGD motif in a bacterial polyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferase [PDF]

Protein Science, 2012
AbstractPolyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferases (PNPTs) constitute a family of eukaryotic and prokaryotic membrane proteins that catalyze the transfer of a sugar‐1‐phosphate to a phosphoisoprenyl lipid carrier. All PNPT members share a highly conserved 213‐Valine‐Phenylalanine‐Methionine‐Glycine‐Aspartic acid‐217 (VFMGD ...
Furlong, Sarah E, Valvano, Miguel A
openaire   +4 more sources

Polyisoprenyl phosphate specificity of UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli [PDF]

Glycobiology, 1997
N-Acetyl-D-glucosaminylpyrophosphorylundecaprenol (GlcNAc-P-P-Und), an intermediate in the biosynthesis of the enterobacterial common antigen in E.coli and some O-antigen chains in gram-negative bacteria, is formed by the transfer of GlcNAc 1-P from UDP-GlcNAc to Und-P, analogous to the reaction forming GlcNAc-P-P-dolichol (GlcNAc-P-P-Dol) in mammalian
J S, Rush, P D, Rick, C J, Waechter
openaire   +3 more sources

Cytotoxic Polyisoprenyl Benzophenonoids from Garcinia subelliptica

Journal of Natural Products, 2010
Six new polyisoprenyl benzophenonoids, (±)-garcinialiptone A (1, 2), garcinialiptone B (3), (−)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and ...
Li-Jie Zhang, Chun-Tang Chiou, Hui-Chi Huang   +2 more
exaly   +2 more sources

Desorption chemical ionization tandem mass spectrometry of polyprenyl and dolichyl phosphates

Journal of the American Society for Mass Spectrometry, 1996
Negative-ion desorption chemical ionization (DCI) tandem mass spectrometry was applied to the analysis of nanomole quantities of semisynthetic polyisoprenyl phosphates, the chain length of which ranged from 7 to 20 isoprene units. The DCI spectrum of all
B. A. Wolucka, Raoul Rozenberg, E. Hoffmann, T. Chojnacki   +3 more
semanticscholar   +2 more sources

The C-terminal domain of the Salmonella enterica WbaP (UDP-galactose:Und-P galactose-1-phosphate transferase) is sufficient for catalytic activity and specificity for undecaprenyl monophosphate. [PDF]

Glycobiology, 2012
Two families of membrane enzymes catalyze the initiation of the synthesis of O-antigen lipopolysaccharide. The Salmonella enterica Typhimurium WbaP is a prototypic member of one of these families.
Kinnari B. Patel, Ewa Ciepichal, E. Swiezewska, M. Valvano   +3 more
semanticscholar   +2 more sources

The two‐component system CroRS acts as a master regulator of cell envelope homeostasis to confer antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis

Molecular Microbiology, Volume 120, Issue 3, Page 408-424, September 2023., 2023
In Enterococcus faecalis, CroRS regulates the expression of cell envelope biosynthesis pathways to maintain homeostasis and confer tolerance upon antimicrobial challenge. Loss of function mutations in the respiratory branch of the isoprenoid pathway appears to rescue tolerance in a croRS deletion mutant.
Francesca O. Todd Rose, Rachel L. Darnell, Sali M. Morris, Olivia E. Rose, Olivia Paxie, Georgia Campbell, Gregory M. Cook, Susanne Gebhard   +7 more
wiley   +1 more source

New insights into natural rubber biosynthesis from rubber‐deficient lettuce mutants expressing goldenrod or guayule cis‐prenyltransferase

New Phytologist, Volume 239, Issue 3, Page 1098-1111, August 2023., 2023
Summary Lettuce produces natural rubber (NR) with an average Mw of > 1 million Da in laticifers, similar to NR from rubber trees. As lettuce is an annual, self‐pollinating, and easily transformable plant, it is an excellent model for molecular genetic studies of NR biosynthesis.
Moonhyuk Kwon, Connor L. Hodgins, Eman M. Salama, Kayla R. Dias, Aalap Parikh, Ashlyn V. Mackey, Karizza F. Catenza, John C. Vederas, Dae‐Kyun Ro   +8 more
wiley   +1 more source

Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors

ChemMedChem, Volume 16, Issue 24, Page 3730-3738, December 14, 2021., 2021
Precision nanomedicines can improve osteosarcoma treatments by enhancing the action of cytostatic agents through selective targeting to the bone tumor area. HbisP−Sq, a lipid molecule with high affinity for calcium ions present in HA has been successfully synthetized.
Carlos Rodríguez‐Nogales, Didier Desmaële, Víctor Sebastián, Patrick Couvreur, María J. Blanco‐Prieto   +4 more
wiley   +1 more source

Identification of the Wzx flippase, Wzy polymerase and sugar‐modifying enzymes for spore coat polysaccharide biosynthesis in Myxococcus xanthus

Molecular Microbiology, Volume 113, Issue 6, Page 1189-1208, June 2020., 2020
Myxococcus xanthus differentiates to environmentally resistant spores in response to various stresses. Resistance is provided by the spore coat polysaccharide that is synthesised by the ExoA‐I proteins, which make up an incomplete Wzx/Wzy pathway for polysaccharide synthesis and export. Here, we identified the Wzx flippase and Wzy polymerase as well as
María Pérez‐Burgos, Inmaculada García‐Romero, Miguel A. Valvano, Lotte Søgaard Andersen   +3 more
wiley   +1 more source

Characterization by NMR and molecular modeling of the binding of polyisoprenols and polyisoprenyl recognition sequence peptides: 3D structure of the complexes reveals sites of specific interactions

Glycobiology, 2003
Guo-Ping Zhou, Troy Frédéric A
exaly   +2 more sources