Results 11 to 20 of about 621 (94)
Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis [PDF]
Nature Communications, 2016 Abstract The attachment of a sugar to a hydrophobic polyisoprenyl carrier is the first step for all extracellular glycosylation processes. The enzymes that perform these reactions, polyisoprenyl-glycosyltransferases (PI-GTs) include dolichol phosphate mannose synthase (DPMS), which generates the mannose donor for ...
Ardiccioni, Chiara +17 more
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Polyisoprenyl phosphate specificity of UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli [PDF]
Glycobiology, 1997 N-Acetyl-D-glucosaminylpyrophosphorylundecaprenol (GlcNAc-P-P-Und), an intermediate in the biosynthesis of the enterobacterial common antigen in E.coli and some O-antigen chains in gram-negative bacteria, is formed by the transfer of GlcNAc 1-P from UDP-GlcNAc to Und-P, analogous to the reaction forming GlcNAc-P-P-dolichol (GlcNAc-P-P-Dol) in mammalian
J S, Rush, P D, Rick, C J, Waechter
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Characterization of the highly conserved VFMGD motif in a bacterial polyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferase [PDF]
Protein Science, 2012 AbstractPolyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferases (PNPTs) constitute a family of eukaryotic and prokaryotic membrane proteins that catalyze the transfer of a sugar‐1‐phosphate to a phosphoisoprenyl lipid carrier. All PNPT members share a highly conserved 213‐Valine‐Phenylalanine‐Methionine‐Glycine‐Aspartic acid‐217 (VFMGD ...
Furlong, Sarah E, Valvano, Miguel A
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Topological analysis of the Escherichia coli WcaJ protein reveals a new conserved configuration for the polyisoprenyl-phosphate hexose-1-phosphate transferase family [PDF]
Scientific Reports, 2015 AbstractWcaJ is an Escherichia coli membrane enzyme catalysing the biosynthesis of undecaprenyl-diphosphate-glucose, the first step in the assembly of colanic acid exopolysaccharide. WcaJ belongs to a large family of polyisoprenyl-phosphate hexose-1-phosphate transferases (PHPTs) sharing a similar predicted topology consisting of an N-terminal domain ...
Furlong, Sarah E. +3 more
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Journal of Biological Chemistry, 1985 The enzymatic dephosphorylation of endogenous and exogenous dolichyl phosphate (Dol-P) by membrane preparations from calf brain has been reported previously (Burton, W.A., Scher, M.G., and Waechter, C. J. (1981) Arch. Biochem. Biophys. 208, 409-417). The study presented here shows that polyisoprenyl phosphate phosphatase activity increases with age in ...
M G, Scher, C M, Sumbilla, C J, Waechter
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Molecular Microbiology, Volume 112, Issue 4, Page 1178-1198, October 2019., 2019 Myxococcus xanthus displays several social behaviors involving cell–cell contacts. To understand the role of the lipopolysaccharide (LPS) in these behaviors, we identified key enzymes involved in O‐antigen and LPS biosynthesis: the polyisoprenyl‐phosphate hexose‐1‐phosphate transferase, responsible for priming O‐antigen synthesis and the O‐antigen ...
María Pérez‐Burgos +4 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016 This review is focused on the possible causes of mitochondrial dysfunction in AD, underlying molecular mechanisms of this malfunction, possible causes and known consequences of APP, Aβ, and hyperphosphorylated tau presence in mitochondria, and the contribution of altered lipid metabolism (nonsterol isoprenoids) to pathological processes leading to ...
Beata Pająk +3 more
wiley +1 more source
Molecular Circuits of Resolution in Airway Inflammation
The Scientific World Journal, Volume 10, Issue 1, Page 1386-1399, 2010., 2010 Inflammatory diseases of the lung are common, cause significant morbidity, and can be refractory to therapy. Airway responses to injury, noxious stimuli, or microbes lead to leukocyte recruitment for host defense. As leukocytes respond, they interact with lung resident cells and can elaborate specific mediators that are enzymatically generated from ...
Troy Carlo, Bruce D. Levy, Joan Clària
wiley +1 more source
The Scientific World Journal, Volume 7, Issue 1, Page 1393-1412, 2007., 2007 Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti‐inflammatory properties, LXA4 and LXB4 being the main components of this series. LXs are generated by cooperation between 5‐lipoxygenase (LO) and 12‐ or 15‐LO during cell‐cell interactions or by single cell types.
Mario Romano +3 more
wiley +1 more source
The Scientific World Journal, Volume 2, Issue 1, Page 169-204, 2002., 2002 It is well appreciated that lipid‐derived mediators play key roles in inflammation and many other physiologic responses where multicellular processes are involved. Among them, lipoxins (LX) and aspirin‐triggered LX (ATL) evoke actions of interest in a range of physiologic and pathophysiologic processes, and these two series have emerged as founding ...
Charles N. Serhan, Nan Chiang
wiley +1 more source