Results 31 to 40 of about 296 (134)
Human Isoprenoid Synthase Enzymes as Therapeutic Targets
Frontiers in Chemistry, 2014 The complex biochemical network known as the mevalonate pathway is responsible for the biosynthesis of all isoprenoids in the human body, which consists of a vast array of metabolites that are vital for proper cellular functions.
Jaeok ePark +3 more
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Farnesyl pyrophosphate is a new danger signal inducing acute cell death.
PLoS Biology, 2021 Cell death is a vital event in life. Infections and injuries cause lytic cell death, which gives rise to danger signals that can further induce cell death, inflammation, and tissue damage.
Jing Chen +13 more
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Correction: Farnesyl pyrophosphate is a new danger signal inducing acute cell death
PLoS Biology, 2023 [This corrects the article DOI: 10.1371/journal.pbio.3001134.].
Jing Chen +13 more
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Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii. [PDF]
PLoS ONE, 2015 Farnesylpyrophosphate synthase (FPS) catalyzes the biosynthesis of farnesyl pyrophosphate (FPP), which is an important precursor of sesquiterpenoids such as artemisinin and wilfordine.
Yu-Jun Zhao +8 more
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Plants, 2021 Terpenoids represent one of the high-value groups of specialized metabolites with vast structural diversity. They exhibit versatile human benefits and have been successfully exploited in several sectors of day-to-day life applications, including ...
Vimalraj Mani +4 more
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Angewandte Chemie International Edition, EarlyView.A non‐canonical C16 sesquiterpene synthase from Morganella morganii produces the unusual scaffold descartane. Its cyclisation mechanism was rationalised by isotopic labelling experiments and DFT calculations. Site‐directed mutagenesis altered enzyme function, resulting in alternative products, including voltairene, which requires a different ...
Kexin Yang +4 more
wiley +1 more source
Molecules, 2017 Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates–Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically
Tamila Galaka +8 more
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Frontiers in Plant Science, 2020 Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon dioxide into biomass, cyanobacteria are promising hosts for the sustainable production of ...
Yuchi Feng +4 more
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Scientific Reports, 2021 Classical terpenoid biosynthesis involves the cyclization of the linear prenyl pyrophosphate precursors geranyl-, farnesyl-, or geranylgeranyl pyrophosphate (GPP, FPP, GGPP) and their isomers, to produce a huge number of natural compounds.
Marie Chantal Lemfack +10 more
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Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
FEBS Open BioMevalonate kinase is a key regulator of the mevalonate pathway, subject to feedback inhibition by the downstream metabolite farnesyl pyrophosphate. In this study, we validated the hypothesis that monophosphonate compounds mimicking farnesyl pyrophosphate
Saman Salari +3 more
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