Results 31 to 40 of about 9,807 (200)
Enzymatic Prenylation of Proteins and Peptides: From Cysteine S-Prenylation to Tryptophan-Selective Biocatalysis. [PDF]
ChemistryThis review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Fujinami D, Ozawa H, Ito S.
europepmc +2 more sources
Effect of detergents on sterol synthesis in a cell-free system of yeast
Journal of Lipid Research, 1982 In order to obtain information about the reactivity of enzymes in sterol synthesis of yeast, the effects of some detergents were investigated. Among the detergents used, Triton X-100 was found to exert a unique action, and its effect on the incorporation
S Hata, T Nishino, N Ariga, H Katsuki
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Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
AMB Express, 2022 Dendrobium nobile Lindl. has been used as a traditional Chinese medicine for a long time, in which the most important compound is dendrobine functioning in a variety of pharmacological activities.
Daoyong Gong +6 more
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Targeting of Mevalonate-Isoprenoid Pathway in Acute Myeloid Leukemia Cells by Bisphosphonate Drugs
Biomedicines, 2022 Metabolic reprogramming represents a hallmark of tumorigenesis to sustain survival in harsh conditions, rapid growth and metastasis in order to resist to cancer therapies.
Emanuela Chiarella +4 more
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The Inhibition of Mevalonic Kinase by Geranyl and Farnesyl Pyrophosphates
Journal of Biological Chemistry, 1968 Abstract The inhibition in vitro of a highly purified preparation of mevalonate kinase by terpenyl pyrophosphates has been studied. Geranyl-PP and farnesyl-PP are potent inhibitors, while isopentenyl-PP, dimethylallyl-PP, and inorganic pyrophosphate do not inhibit significantly.
J K, Dorsey, J W, Porter
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Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS
Molecules, 2018 Isoprenoids (IsoP) are an important class of molecules involved in many different cellular processes including cholesterol synthesis. We have developed a sensitive and specific LC-MS/MS method for the quantitation of three key IsoPs in bio-matrices ...
Yashpal S. Chhonker +4 more
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Biological effects of trans, trans-farnesol in Leishmania amazonensis
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionFarnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers.
Liliane Sena Pinheiro +9 more
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Journal of Biological Chemistry, 1985 The prenyl transferase undecaprenyl pyrophosphate synthetase was partially purified from the cytosolic fraction of Escherichia coli. Its enzymic products were characterized as a family of cis-polyprenyl phosphates, which ranged in carbon number from C55 to C25. The enzyme is constituted of two subunits of approximately 30,000 molecular weight.
T, Baba, J, Muth, C M, Allen
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Cellular Physiology and Biochemistry, 2016 Background: In our previous study, farnesyl pyrophosphate synthase (FPPS) was shown to be increased in spontaneously hypertensive rats (SHR) and in mice with angiotensin-II induced cardiac hypertrophy.
Jian Yang +4 more
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Journal of Lipid Research, 1960 The biosynthesis of allyl pyrophosphates (the pyrophosphates of dimethylallyl alcohol, geraniol, and of farnesol) from dl-mevalonate-2-C14 and from (-)5-phosphomevalonate-2-C14 with soluble liver enzymes in the presence of ATP and Mg++ is described.
Dew.S. Goodman, G. Popják
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