Results 31 to 40 of about 15,452 (211)

The TriForC database : a comprehensive up-to-date resource of plant triterpene biosynthesis [PDF]

, 2018
Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds.
Bak, Soren, Botzki, Alexander, Coppens, Frederik, De Bo, Christof, Goossens, Alain, Iñigo, Sabrina, Kreft, Lukasz, Miettinen, Karel, Pollier, Jacob   +8 more
core   +2 more sources

Farnesyl pyrophosphate synthase modulators: a patent review (2006 – 2010) [PDF]

Expert Opinion on Therapeutic Patents, 2011
Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of diseases, including bone-related disorders characterized by excessive bone resorption ...
Shuting, Sun, Charles E, McKenna
openaire   +2 more sources

Targeting of Mevalonate-Isoprenoid Pathway in Acute Myeloid Leukemia Cells by Bisphosphonate Drugs

Biomedicines, 2022
Metabolic reprogramming represents a hallmark of tumorigenesis to sustain survival in harsh conditions, rapid growth and metastasis in order to resist to cancer therapies.
Emanuela Chiarella, Clelia Nisticò, Anna Di Vito, Helen Linda Morrone, Maria Mesuraca   +4 more
doaj   +1 more source

Carbocations and the Complex Flavor and Bouquet of Wine: Mechanistic Aspects of Terpene Biosynthesis in Wine Grapes. [PDF]

, 2015
Computational chemistry approaches for studying the formation of terpenes/terpenoids in wines are presented, using five particular terpenes/terpenoids (1,8-cineole, α-ylangene, botrydial, rotundone, and the wine lactone), volatile compounds (or their ...
Pemberton, Ryan P, Tantillo, Dean J, Wedler, Henry B   +2 more
core   +2 more sources

Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes [PDF]

, 2015
Background Juvenile hormones (JH) regulate development and reproductive maturation in insects. JHs are synthesized through the mevalonate pathway (MVAP), an ancient metabolic pathway present in the three domains of life.
Noriega, Fernando G., Nyati, Pratik, Rivera-Perez, Crisalejandra   +2 more
core   +6 more sources

Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS

Molecules, 2018
Isoprenoids (IsoP) are an important class of molecules involved in many different cellular processes including cholesterol synthesis. We have developed a sensitive and specific LC-MS/MS method for the quantitation of three key IsoPs in bio-matrices ...
Yashpal S. Chhonker, Staci L. Haney, Veenu Bala, Sarah A. Holstein, Daryl J. Murry   +4 more
doaj   +1 more source

Biological effects of trans, trans-farnesol in Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionFarnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers.
Liliane Sena Pinheiro, Liliane Sena Pinheiro, Valter Viana Andrade-Neto, Marcio Mantuano-Barradas, Elisa Cavalcante Pereira, Rodrigo Cesar Fernandes Barbosa, Marcia Cristina Campos de Oliveira, Rubem Figueiredo Sadok Menna-Barreto, Edézio Ferreira Cunha-Júnior, Eduardo Caio Torres-Santos   +9 more
doaj   +1 more source

Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes† [PDF]

, 2018
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition.
Amos, Ayres, Bergstrom, Bergstrom, Bicalho, Billington, Bloch, Bonnett, Bustin, Christian, Cronin, Forman, Fukuchi, Gan, Gareth D Healey, Goldstein, Goldstein, Gonzalez, Griffin, Gurcel, Hardie, Healy, Hiyoshi, Huffman, I Martin Sheldon, Jost, Kalaany, Karstrup, Keller, Lange, LeBlanc, LeBlanc, Liao, Maxfield, McCusker, Mihaylova, Moore, Morgan, Mosmann, Park, Peraro, Preta, Preta, Read, Repa, Schneider, Sharpe, Sheldon, Sheldon, Sholeem Griffin, Statt, Turner, Turner, Tweten, Vander Heiden, Wang, Wathes, Westermann, Zoncu, Zwald   +59 more
core   +1 more source

Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea [PDF]

, 2016
Cell sorting coupled with single-cell genomics is a powerful tool to circumvent cultivation of microorganisms and reveal microbial ‘dark matter’. Single-cell Raman spectra (SCRSs) are label-free biochemical ‘fingerprints’ of individual cells, which can ...
Davison, Paul A., Frentrup, Martinique, Huang, Wei E., Hunter, C. Neil, Kaster, Anne-Kristin, Murrell, J. Colin, Preston, Gail M., Song, Yanqing, Song, Yizhi, Thompson, Ian P., Vollmers, John, Yin, Huabing   +11 more
core   +4 more sources

Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats

Cellular Physiology and Biochemistry, 2016
Background: In our previous study, farnesyl pyrophosphate synthase (FPPS) was shown to be increased in spontaneously hypertensive rats (SHR) and in mice with angiotensin-II induced cardiac hypertrophy.
Jian Yang, Yu-Ning Chen, Zao-Xian Xu, Yun Mou, Liang-Rong Zheng   +4 more
doaj   +1 more source