Results 21 to 30 of about 296 (134)
Biological effects of trans, trans-farnesol in Leishmania amazonensis
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionFarnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers.
Liliane Sena Pinheiro +9 more
doaj +1 more source
The Inhibition of Mevalonic Kinase by Geranyl and Farnesyl Pyrophosphates
Journal of Biological Chemistry, 1968 Abstract The inhibition in vitro of a highly purified preparation of mevalonate kinase by terpenyl pyrophosphates has been studied. Geranyl-PP and farnesyl-PP are potent inhibitors, while isopentenyl-PP, dimethylallyl-PP, and inorganic pyrophosphate do not inhibit significantly.
J K, Dorsey, J W, Porter
openaire +2 more sources
Cellular Physiology and Biochemistry, 2016 Background: In our previous study, farnesyl pyrophosphate synthase (FPPS) was shown to be increased in spontaneously hypertensive rats (SHR) and in mice with angiotensin-II induced cardiac hypertrophy.
Jian Yang +4 more
doaj +1 more source
Journal of Lipid Research, 1960 The biosynthesis of allyl pyrophosphates (the pyrophosphates of dimethylallyl alcohol, geraniol, and of farnesol) from dl-mevalonate-2-C14 and from (-)5-phosphomevalonate-2-C14 with soluble liver enzymes in the presence of ATP and Mg++ is described.
Dew.S. Goodman, G. Popják
doaj +1 more source
Journal of Integrative Agriculture, 2020 Sesquiterpenoids play an import role in the direct or indirect defense of plants. Farnesyl pyrophosphate synthases (FPSs) catalyze the biosynthesis of farnesyl pyrophosphate, which is a key precursor of farnesol and (E)-β-farnesene. In the current study,
Hong ZHANG +6 more
doaj +1 more source
Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases
Rheumatology & Autoimmunity, 2022 All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs).
Na Kang +3 more
doaj +1 more source
Journal of Biological Chemistry, 1985 The prenyl transferase undecaprenyl pyrophosphate synthetase was partially purified from the cytosolic fraction of Escherichia coli. Its enzymic products were characterized as a family of cis-polyprenyl phosphates, which ranged in carbon number from C55 to C25. The enzyme is constituted of two subunits of approximately 30,000 molecular weight.
T, Baba, J, Muth, C M, Allen
openaire +2 more sources
Frontiers in Plant Science, 2018 Terpenes serve important physiological and ecological functions in plants. Sindora glabra trees accumulate copious amounts of sesquiterpene-rich oleoresin in the stem. A transcriptome approach was used to determine the unique terpene biosynthesis pathway
Niu Yu +4 more
doaj +1 more source
Antibacterial effect of some eukaryotic sterol biosynthesis inhibitors
Advanced Biomedical Research, 2022 Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in ...
Ghasem Arjmand, Mohammad Reza Haeri
doaj +1 more source
Frontiers in Microbiology, 2019 We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall.
Marko Jukič +4 more
doaj +1 more source