Regulation of Fatty Acid Synthesis by Farnesyl Pyrophosphate [PDF]
Journal of Biological Chemistry, 2005 Fatty acid biosynthesis is transcriptionally regulated by liver X receptor (LXR) and its gene target, sterol regulatory element binding protein-1c (SREBP-1c). LXR activation is induced by oxysterol end products of the mevalonate pathway and is inhibited by the upstream non-sterol isoprenoid, geranylgeranyl pyrophosphate (GGPP). Whether isoprenoids play
Shubha, Murthy +2 more
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Photoaffinity Analogues of Farnesyl Pyrophosphate Transferable by Protein Farnesyl Transferase
, 2016 Farnesylation is a posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins in a reaction catalyzed by protein farnesyltransferase (FTase).
Katarzyna Kiegiel (2986188) +7 more
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Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase
Nature Communications, 2023 Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates substrate promiscuity by accepting geranyl pyrophosphate and farnesyl pyrophosphate ...
Zhong Li +16 more
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Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate
Journal of Lipid Research, 1969 Several mechanisms that utilize farnesyl pyrophosphate and nerolidyl pyrophosphate as condensing substrates have been postulated for the asymmetric condensation reaction in squalene biosynthesis.
S.S. Sofer, H.C. Rilling
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Journal of Lipid Research, 1973 Homogenates and subcellular fractions of the intima–media of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene.
Linda L. Slakey +3 more
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Sites of control of hepatic cholesterol biosynthesis
Journal of Lipid Research, 1966 An inhibition in the conversion of mevalonate to cholesterol has been demonstrated in liver of cholesterol-fed rats by both in vitro and in vivo methods.
R. Gordon Gould, E.A. Swyryd
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Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase fromPseudomonas aeruginosa [PDF]
Acta Crystallographica Section D: Biological Crystallography, 2015 Jason W Schmidberger, Robert Schnell
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Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase [PDF]
Current Medicinal Chemistry, 2011 Bisphosphonates (BPs) are the most widely used and effective treatment for osteoporosis and Paget's disease. Non-nitrogen containing BPs (non-N-BPs), namely etidronate, clodronate, tiludronate, as well as nitrogen containing BPs (N-BPs), namely pamidronate, alendronate, ibandronate, risedronate, zoledronate and minodronate have been launched on the ...
Ohno, K, Mori, K, Orita, M, Takeuchi, M
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Biosynthesis of presqualene pyrophosphate by liver microsomes
Journal of Lipid Research, 1970 Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been ...
H.C. RILLING
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Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. [PDF]
PLoS ONE, 2013 In vitro synthesis of chemicals and pharmaceuticals using enzymes is of considerable interest as these biocatalysts facilitate a wide variety of reactions under mild conditions with excellent regio-, chemo- and stereoselectivities.
Xixian Chen +5 more
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