Results 41 to 50 of about 15,452 (211)

Production of ent-kaurene from lignocellulosic hydrolysate in Rhodosporidium toruloides. [PDF]

, 2020
BACKGROUND:Rhodosporidium toruloides has emerged as a promising host for the production of bioproducts from lignocellulose, in part due to its ability to grow on lignocellulosic feedstocks, tolerate growth inhibitors, and co-utilize sugars and lignin ...
Burnum-Johnson, Kristin E, Clay, Derek M, Gao, Yuqian, Geiselman, Gina M, Gladden, John M, Kirby, James, Magnuson, Jon K, Munoz Munoz, Nathalie, Nicora, Carrie D, Papa, Gabriella, Prahl, Jan-Philip, Skerker, Jeffrey M, Sundstrom, Eric R, Tanjore, Deepti, Tran-Gyamfi, Mary B, Zhuang, Xun   +15 more
core   +1 more source

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells [PDF]

, 2006
BACKGROUND: Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway ...
M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye, S Séronie-Vivien, MJ Rogers, JR Green, D Amin, JD Bergstrom, K Thompson, E van Beek, HL Benford, SP Luckman, T Iguchi, JE Fisher, K Sawada, C Denoyelle, FP Coxon, ER Van Beek, GM Oades, SG Senaratne, SS Virtanen, F Saad, MR Smith, S Boissier, MV Lee, EC Lerner, TF McGuire, O Cussenot, P Skehan, AB Awad, E Corey, DC Crick, RB Lobell, SA Holstein, SE Ownby, C Allal, JE Dunford, JE Fisher   +40 more
core   +2 more sources

Photoaffinity labeling of undecaprenyl pyrophosphate synthetase with a farnesyl pyrophosphate analogue.

Journal of Biological Chemistry, 1985
The prenyl transferase undecaprenyl pyrophosphate synthetase was partially purified from the cytosolic fraction of Escherichia coli. Its enzymic products were characterized as a family of cis-polyprenyl phosphates, which ranged in carbon number from C55 to C25. The enzyme is constituted of two subunits of approximately 30,000 molecular weight.
T, Baba, J, Muth, C M, Allen
openaire   +2 more sources

Studies on the biosynthesis of cholesterol: XII. synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes*

Journal of Lipid Research, 1960
The biosynthesis of allyl pyrophosphates (the pyrophosphates of dimethylallyl alcohol, geraniol, and of farnesol) from dl-mevalonate-2-C14 and from (-)5-phosphomevalonate-2-C14 with soluble liver enzymes in the presence of ATP and Mg++ is described.
Dew.S. Goodman, G. Popják
doaj   +1 more source

Two farnesyl pyrophosphate synthases, GhFPS1–2, in Gossypium hirsutum are involved in the biosynthesis of farnesol to attract parasitoid wasps

Journal of Integrative Agriculture, 2020
Sesquiterpenoids play an import role in the direct or indirect defense of plants. Farnesyl pyrophosphate synthases (FPSs) catalyze the biosynthesis of farnesyl pyrophosphate, which is a key precursor of farnesol and (E)-β-farnesene. In the current study,
Hong ZHANG, Xin-zheng HUANG, Wei-xia JING, Dan-feng LIU, Khalid Hussain DHILOO, Zhi-min HAO, Yong-jun ZHANG   +6 more
doaj   +1 more source

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Rheumatology & Autoimmunity, 2022
All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs).
Na Kang, Xiaohang Liu, Kabeer Haneef, Wanli Liu   +3 more
doaj   +1 more source

Comparative analysis and validation of the malachite green assay for the high throughput biochemical characterization of terpene synthases [PDF]

, 2014
Terpenes are the largest group of natural products with important and diverse biological roles, while of tremendous economic value as fragrances, flavours and pharmaceutical agents.
Apfel, Carter, Connolly, Degenhardt, Dewick, D’Angelo, Faraldos, Faraldos, Feng, Fisher, Fraga, Garrett, Hall, Hanson, Harder, Itaya, Jenkins, Karp, Krueger, Lauchli, Meyers, Moslen, O’Maille, O’Maille, O’Maille, Pegan, Penney, Petitou, Picaud, Picaud, Rabe, Woodside, Wu, Wu, Yi   +34 more
core   +2 more sources

Transcriptome Analysis of Oleoresin-Producing Tree Sindora Glabra and Characterization of Sesquiterpene Synthases

Frontiers in Plant Science, 2018
Terpenes serve important physiological and ecological functions in plants. Sindora glabra trees accumulate copious amounts of sesquiterpene-rich oleoresin in the stem. A transcriptome approach was used to determine the unique terpene biosynthesis pathway
Niu Yu, Jin-Chang Yang, Guang-Tian Yin, Rong-Sheng Li, Wen-Tao Zou   +4 more
doaj   +1 more source

Antibacterial effect of some eukaryotic sterol biosynthesis inhibitors

Advanced Biomedical Research, 2022
Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in ...
Ghasem Arjmand, Mohammad Reza Haeri
doaj   +1 more source

Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis

Frontiers in Microbiology, 2019
We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall.
Marko Jukič, Kaja Rožman, Matej Sova, Hélène Barreteau, Stanislav Gobec   +4 more
doaj   +1 more source