Results 41 to 50 of about 9,807 (200)

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Rheumatology & Autoimmunity, 2022
All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs).
Na Kang, Xiaohang Liu, Kabeer Haneef, Wanli Liu   +3 more
doaj   +1 more source

Transcriptome Analysis of Oleoresin-Producing Tree Sindora Glabra and Characterization of Sesquiterpene Synthases

Frontiers in Plant Science, 2018
Terpenes serve important physiological and ecological functions in plants. Sindora glabra trees accumulate copious amounts of sesquiterpene-rich oleoresin in the stem. A transcriptome approach was used to determine the unique terpene biosynthesis pathway
Niu Yu, Jin-Chang Yang, Guang-Tian Yin, Rong-Sheng Li, Wen-Tao Zou   +4 more
doaj   +1 more source

Antibacterial effect of some eukaryotic sterol biosynthesis inhibitors

Advanced Biomedical Research, 2022
Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in ...
Ghasem Arjmand, Mohammad Reza Haeri
doaj   +1 more source

Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis

Frontiers in Microbiology, 2019
We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall.
Marko Jukič, Kaja Rožman, Matej Sova, Hélène Barreteau, Stanislav Gobec   +4 more
doaj   +1 more source

Human Isoprenoid Synthase Enzymes as Therapeutic Targets

Frontiers in Chemistry, 2014
The complex biochemical network known as the mevalonate pathway is responsible for the biosynthesis of all isoprenoids in the human body, which consists of a vast array of metabolites that are vital for proper cellular functions.
Jaeok ePark, Alexios eMatralis, Albert M. Berghuis, Youla S Tsantrizos   +3 more
doaj   +1 more source

Chirality-Driven Mode of Binding of α‑Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)

, 2019
Thienopyrimidine-based allosteric inhibitors of the human farnesyl pyrophosphate synthase (hFPPS), characterized by a chiral α-aminophosphonic acid moiety, were synthesized as enantiomerically enriched pairs, and their binding mode was investigated by X ...
Jaeok Park (1779922), Yuting Feng (4469830), Matthew A. Schilling (7506605), Albert M. Berghuis (352046), Shi-Guang Li (1710196), Youla S. Tsantrizos (1751008), Rebecca Boutin (7506602), Peter Viereck (3714121)   +7 more
core   +2 more sources

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Solubilization and Purification of trans-Farnesyl Pyrophosphate-Squalene Synthetase

Journal of Biological Chemistry, 1971
Abstract A trans-farnesyl pyrophosphate-squalene synthetase has been isolated in a soluble form from yeast extracts and purified 45-fold. The molecular weight of the enzyme estimated from sucrose density gradient centrifugation and gel filtration chromatography is 426,000.
I, Shechter, K, Bloch
openaire   +2 more sources

Separation of trichothecene mycotoxins in a matrix of hemp (Cannabis sativa L.) seed, and quantification of deoxynivalenol in hemp grain infected with Fusarium graminearum

JSFA reports, EarlyView.
Abstract Background Fusarium graminearum, one of the causal agents of ear rot in maize and head blight of cereal grains, also infects hemp (Cannabis sativa L. containing a maximum of 0.3% tetrahydrocannabinol or THC). This fungal pathogen produces trichothecene mycotoxins when it infects maize and cereal grains, but little is known about its production
Isabelle A. Kagan, Magdalena Ricciardi, Henry S. Smith, Rachel R. Schendel, Robert Pearce, Nicole Gauthier   +5 more
wiley   +1 more source

Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis

Frontiers in Plant Science, 2020
Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon dioxide into biomass, cyanobacteria are promising hosts for the sustainable production of ...
Yuchi Feng, R. Marc L. Morgan, Paul D. Fraser, Klaus Hellgardt, Peter J. Nixon   +4 more
doaj   +1 more source