Results 41 to 50 of about 296 (134)

Systematic characterization and functional analysis of trans-prenyltransferases in Curcuma wenyujin

Frontiers in Plant Science
IntroductionCurcuma wenyujin (Zingiberaceae), a medicinally significant species within the Curcuma genus, is highly regarded in traditional Chinese medicine for its rich terpenoid constituents.
Qian Wang, Yi Su, Tingyu Ye, Shiyi Wu, Huan Liu, Jingwen Sun, Xiu Yin, Tianyuan Hu, Xiaoxia Ma, Shujuan Zhao, Xinde Xu, Xiaopu Yin, Qiuhui Wei, Qiuhui Wei, Qiuhui Wei   +14 more
doaj   +1 more source

Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways

Frontiers in Pharmacology, 2018
Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR).
Tingting Chen, Tingting Chen, Ya Wang, Tingting Zhang, Tingting Zhang, Baofeng Zhang, Lei Chen, Liandong Zhao, Ling Chen, Ling Chen   +9 more
doaj   +1 more source

Solubilization and Purification of trans-Farnesyl Pyrophosphate-Squalene Synthetase

Journal of Biological Chemistry, 1971
Abstract A trans-farnesyl pyrophosphate-squalene synthetase has been isolated in a soluble form from yeast extracts and purified 45-fold. The molecular weight of the enzyme estimated from sucrose density gradient centrifugation and gel filtration chromatography is 426,000.
I, Shechter, K, Bloch
openaire   +2 more sources

Evolutionary, Functional and Mechanistic Characterisation of Microbial Terpene Synthase‐Like Genes From Springtails

Angewandte Chemie International Edition, EarlyView.
A genome analysis revealed the presence of many bacterial‐type terpene synthases in springtails. Four enzymes from Sinella curviseta were functionally characterised, resulting in the isolation of several compounds including sinellene ether, the first diterpene ether identified from a terpene synthase that represents a novel skeleton.
Min Wang, Clement Schneider, Zarley Rebholz, Stefan Schulz, Kathy Darragh, Jeroen S. Dickschat   +5 more
wiley   +1 more source

Cwh8 moonlights as a farnesyl pyrophosphate phosphatase and is essential for farnesol biosynthesis in Candida albicans

mBio
In the opportunistic pathogen Candida albicans, hyphal growth and virulence factor expression are regulated by environmental and chemical cues. Farnesol is a secreted autoregulatory molecule that represses filamentation.
Daniel J. Gutzmann, Cory H. T. Boone, Brigid M. Toomey, Shyanne Urbin, Wayne R. Riekhof, Deborah A. Hogan, Audrey L. Atkin, Kenneth W. Nickerson   +7 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Separation of trichothecene mycotoxins in a matrix of hemp (Cannabis sativa L.) seed, and quantification of deoxynivalenol in hemp grain infected with Fusarium graminearum

JSFA reports, EarlyView.
Abstract Background Fusarium graminearum, one of the causal agents of ear rot in maize and head blight of cereal grains, also infects hemp (Cannabis sativa L. containing a maximum of 0.3% tetrahydrocannabinol or THC). This fungal pathogen produces trichothecene mycotoxins when it infects maize and cereal grains, but little is known about its production
Isabelle A. Kagan, Magdalena Ricciardi, Henry S. Smith, Rachel R. Schendel, Robert Pearce, Nicole Gauthier   +5 more
wiley   +1 more source

Debneyol decoded: A metabolic organizer powers broad‐spectrum plant defense

New Plant Protection, EarlyView.
Abstract A new Cell study by Wang et al. resolves the long‐elusive biosynthesis and regulation of debneyol, a fungicidal sesquiterpenoid phytoalexin in Solanaceae. The authors define the complete three‐step route from farnesyl pyrophosphate to debneyol and identify the small protein MCD1 as a metabolic organizer that assembles a multienzyme complex to ...
Shaojie Han
wiley   +1 more source

Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production

Frontiers in Microbiology, 2019
Terpenoids are natural products known for their medicinal and commercial applications. Metabolic engineering of microbial hosts for the production of valuable compounds, such as artemisinin and Taxol, has gained vast interest in the last few decades. The
Ingy I. Abdallah, Hegar Pramastya, Hegar Pramastya, Ronald van Merkerk, Sukrasno, Wim J. Quax   +5 more
doaj   +1 more source

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

Insect Science, EarlyView.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji, Qing Xie, Xiaoxiao Chang, Juan Shi   +3 more
wiley   +1 more source