Results 51 to 60 of about 9,807 (200)

Metabolic Perturbation and Synthetic Biology Strategies for Plant Terpenoid Production—An Updated Overview

Plants, 2021
Terpenoids represent one of the high-value groups of specialized metabolites with vast structural diversity. They exhibit versatile human benefits and have been successfully exploited in several sectors of day-to-day life applications, including ...
Vimalraj Mani, Soyoung Park, Jin A Kim, Soo In Lee, Kijong Lee   +4 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites

Molecules, 2017
Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates–Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically
Tamila Galaka, Mariana Ferrer Casal, Melissa Storey, Catherine Li, María N. Chao, Sergio H. Szajnman, Roberto Docampo, Silvia N. J. Moreno, Juan B. Rodriguez   +8 more
doaj   +1 more source

Farnesyl pyrophosphate synthetase. Mechanistic studies of the 1\u27-4 coupling reaction with 2-fluorogeranyl pyrophosphate. [PDF]

, 1978
journal articleThe mechanism of the 1\u27-4 coupling reaction between isopentenyl pyrophosphate and geranyl pyrophosphate catalyzed by farnesyl pyrophosphate synthetase from porcine liver was studied with the allylic substrate analogue 2-fluorogeranyl ...
Poulter, Charles Dale, Argyle, J. Craig; Marsh, Eugene A.   +1 more
core  

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

Insect Science, EarlyView.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji, Qing Xie, Xiaoxiao Chang, Juan Shi   +3 more
wiley   +1 more source

Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways

Frontiers in Pharmacology, 2018
Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR).
Tingting Chen, Tingting Chen, Ya Wang, Tingting Zhang, Tingting Zhang, Baofeng Zhang, Lei Chen, Liandong Zhao, Ling Chen, Ling Chen   +9 more
doaj   +1 more source

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation [PDF]

Neuroscience, 2012
Simvastatin (SV), a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase and a widely prescribed treatment for hypercholesterolemia, exerts numerous positive pleiotropic effects that are thought to occur independent of its cholesterol-lowering properties.
R A, Mans, L L, McMahon, L, Li
openaire   +2 more sources

Molecular characterization of two isoforms of a farnesyl pyrophosphate synthase gene in wheat and their roles in sesquiterpene synthesis and inducible defence against aphid infestation

, 2015
Aphids are important pests of wheat (Triticum aestivum) that affect crop production globally. Herbivore-induced emission of sesquiterpenes can repel pests, and farnesyl pyrophosphate synthase (FPS) is a key enzyme involved in sesquiterpene biosynthesis ...
Toby J. A. Bruce, Cheng, Xian-Guo, Shi, Y., Birkett, Michael A., Napier, Johnathan A., Jones, Huw D., Jones, H. D., Pickett, John A., Zhang, Y., Johnathan A. Napier, Birkett, M. A., Yi Shi, Jia Fan, Caulfield, John, Zhao, G-Y., Xian‐Guo Cheng, Fan, J., Xia, L-Q., Zhang, Yan, Bruce, Toby J. A., Lan‐Qin Xia, Michael A. Birkett, Fan, Jia, Xia, Lan‐Qin, Yu, Xiu-Dao, Yu, X-D., Xiu‐Dao Yu, Zhao, Guang‐Yao, Guang‐Yao Zhao, Li, Z-X., Napier, J. A., Yan Zhang, Li, Zhi-Xia, Cheng, Xian‐Guo, Shi, Yi, Zhi‐Xia Li, Bruce, T. J. A., John Caulfield, Zhou, J-J., Jing‐Jiang Zhou, Cheng, X-G., Zhou, Jing-Jiang, John A. Pickett, Xia, Lan-Qin, Zhou, Jing‐Jiang, Pickett, J. A., Yu, Xiu‐Dao, Huw D. Jones, Zhao, Guang-Yao, Caulfield, J., Li, Zhi‐Xia   +50 more
core   +1 more source

LsFAMeT and LsJHAMT coordinate JH biosynthesis to regulate fecundity in Laodelphax striatellus

Insect Science, EarlyView.
The small brown planthopper (SBPH), Laodelphax striatellus, can trigger large‐scale outbreaks when encountering suitable habitats during migration due to their strong reproductive ability. This study investigated the role of juvenile hormone (JH) in regulating SBPH reproduction.
Yan Guo, Bing‐Bing Shi, Xue‐Qi Zhang, Qiong Yang   +3 more
wiley   +1 more source

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase

, 2017
The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP).
Jaeok Park (1779922), Michail Tsakos (3801736), Albert M. Berghuis (352046), Chun Yuen Leung (1779931), Cyrus M. Lacbay (3801733), Youla S. Tsantrizos (1751008), Alexios N. Matralis (3801739), Guillermo Fernandez De Troconiz (3801742)   +7 more
core   +1 more source