Results 51 to 60 of about 15,452 (211)
Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist [PDF]
Biochemical Journal, 2011 The cholesterol biosynthetic pathway produces not only sterols but also non-sterol mevalonate metabolites involved in isoprenoid synthesis. Mevalonate metabolites affect transcriptional and post-transcriptional events that in turn affect various biological processes including energy metabolism.
Goto, Tsuyoshi +12 more
openaire +2 more sources
Human Isoprenoid Synthase Enzymes as Therapeutic Targets
Frontiers in Chemistry, 2014 The complex biochemical network known as the mevalonate pathway is responsible for the biosynthesis of all isoprenoids in the human body, which consists of a vast array of metabolites that are vital for proper cellular functions.
Jaeok ePark +3 more
doaj +1 more source
Plants, 2021 Terpenoids represent one of the high-value groups of specialized metabolites with vast structural diversity. They exhibit versatile human benefits and have been successfully exploited in several sectors of day-to-day life applications, including ...
Vimalraj Mani +4 more
doaj +1 more source
The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension [PDF]
, 2012 Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease. One feature of hypertension is a hyperresponsiveness to contractile agents, and inhibition of vasoconstriction forms the basis
Roberts, Richard E.
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Chemistry – A European Journal, EarlyView.This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami +2 more
wiley +1 more source
Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum [PDF]
, 2011 The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human ...
JORDÃO, Fabiana Morandi +2 more
core +3 more sources
Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase [PDF]
Current Medicinal Chemistry, 2011 Bisphosphonates (BPs) are the most widely used and effective treatment for osteoporosis and Paget's disease. Non-nitrogen containing BPs (non-N-BPs), namely etidronate, clodronate, tiludronate, as well as nitrogen containing BPs (N-BPs), namely pamidronate, alendronate, ibandronate, risedronate, zoledronate and minodronate have been launched on the ...
Ohno, K, Mori, K, Orita, M, Takeuchi, M
openaire +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu +2 more
wiley +1 more source
Frontiers in Plant Science, 2020 Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon dioxide into biomass, cyanobacteria are promising hosts for the sustainable production of ...
Yuchi Feng +4 more
doaj +1 more source
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]
, 2006 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E +6 more
core +1 more source