Results 71 to 80 of about 9,807 (200)

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Legumain activity and expression after treatment with simvastatin, mevalonolactone, geranylgeranyl pyrophosphate and/or farnesyl pyrophosphate.

, 2014
Differentiated myotubes were incubated for 48(0–40 µM) with or without mevalonolactone (50 or 1000 µM; ML), geranylgeranyl pyrophosphate (3 µM; GGPP) or farnesyl pyrophosphate (3 µM; FPP) prior to harvesting at day 7. A.
Linn Løkken Jacobsen (506954), G. Hege Thoresen (177092), Harald Thidemann Johansen (506956), Rigmor Solberg (103828), Arild Christian Rustan (396868), Robert Smith (2450401), Anette Larsen Voreland (506955)   +6 more
core   +1 more source

Aphid alarm pheromone (E)‐β‐farnesene: mechanisms, applications, and challenges in pest management

New Plant Protection, Volume 3, Issue 2, June 2026.
This review highlights the advances in the application of the aphid alarm pheromone (E)‐β‐farnesene (EβF) for pest management. It focuses on smart delivery systems, molecular optimization, synthetic biology, and integration with digital agriculture. Additionally, it discusses key challenges and future directions for enhancing stability, field efficacy,
Yi Yan, Yunhui Zhang, Xuguo Zhou, Xiangrui Li   +3 more
wiley   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.

, 2006
Modification of GTPases with isoprenoid molecules derived from geranylgeranyl pyrophosphate or farnesyl pyrophosphate is an essential requisite for cellular signaling pathways. The synthesis of these isoprenoids proceeds in mammals through the mevalonate
Kavanagh, KL, Oppermann, Udo, Bunkoczi, Gabor, Oppermann, U, Russell, RG, Dunford, JE, Bunkoczi, G, Kavanagh, Kathryn L, Dunford, James E, Dunford, James, Russell, R Graham G   +10 more
core   +1 more source

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan, Ameer Y. Taha, Walter Swardfager   +2 more
wiley   +1 more source

Systematic characterization of ubiquitination modification of EuFPS1 in Eucommia ulmoides

Industrial Crops and Products
The enzyme Farnesyl pyrophosphate Synthase (FPS) plays a critical role in the production process of Eucommia ulmoides rubber (Eu-rubber), catalyzing the production of farnesyl pyrophosphate (FPP), the direct precursor for rubber formation.
Yuhuan Jia, Qing Liang, Yi Zhang, Dan Zhao, Degang Zhao   +4 more
doaj   +1 more source

Farnesyl Pyrophosphate Analogs

, 2001
The post-translational addition of a farnesyl moiety to the Ras oncoprotein is essential for its membrane localization and is required for both its biological activity and ability to induce malignant transformation. The present invention describes design
Chehade, Kareem A.H., Spielmann, Hans Peter, Andres, Douglas A.   +2 more
core  

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source