Results 71 to 80 of about 296 (134)

The Enigma of Sponge-Derived Terpenoid Isothiocyanate–Thiocyanate Pairs: A Biosynthetic Proposal

Marine Drugs
The co-occurrence of rare terpenoid thiocyanates (R-SCN), structurally similar to their more common isothiocyanate isomers (R-NCS), poses an enigma: how does the accepted path, terpenyl cation R+ → R-NC → R-NCS, accommodate R-SCN?
Tadeusz F. Molinski
doaj   +1 more source

Development of a Komagataella phaffii cell factory for sustainable production of ( +)-valencene

Microbial Cell Factories
Background Sesquiterpene ( +)-valencene is a characteristic aroma component from sweet orange fruit, which has a variety of biological activities and is widely used in industrial manufacturing of food, beverage and cosmetics industries.
Jintao Cheng, Jiali Chen, Dingfeng Chen, Baoxian Li, Chaozhi Wei, Tao Liu, Xiao Wang, Zhengshun Wen, Yuanxiang Jin, Chenfan Sun, Guiling Yang   +10 more
doaj   +1 more source

Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages

Journal of Bacteriology
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M.
Matheus da Silva Rocha, Antônio Marcos Rodrigues Pereira, Plínio Marcos Freire dos Santos, André Alves Dias, Melissa Pontes Pereira, Patrícia Sammarco Rosa, Daniele F. F. Bertoluci, John T. Belisle, Fabricio da Mota Ramalho Costa, Cristiana Santos de Macedo, Maria Cristina Vidal Pessolani, Marcia Berrêdo-Pinho   +11 more
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Regulation of Steroidal Alkaloid Biosynthesis in Bulbs of Fritillaria thunbergii Miq. By Shading and Potassium Application: Integrating Transcriptomics and Metabolomics Analyses

Biology
Fritillaria thunbergii Miq., a medicinal plant rich in steroidal alkaloids, produces bulbs that clear heat, resolve phlegm, and detoxify. However, excessive yield-oriented cultivation has reduced the number of F.
Jia Liu, Zixuan Zhu, Leran Wang, Qiang Yuan, Honghai Zhu, Xiaoxiao Sheng, Kejie Zhang, Bingbing Liang, Huizhen Jin, Shumin Wang, Wenjun Weng, Hui Wang, Ning Sui   +12 more
doaj   +1 more source

Farnesyl Pyrophosphate Synthetase [PDF]

, 2020
openaire   +1 more source

Molecular insights into a distinct class of terpenoid cyclases

Nature Communications
Terpenoid cyclases (TCs) account for the synthesis of the most widespread and diverse natural compounds. A sesquiterpene cyclase termed BcABA3 from an abscisic acid-producing fungus Botrytis cinerea that yields (2Z,4E)-α-ionylideneethane but lacks ...
Siyu Li, Jian-Wen Huang, Jian Min, Hao Li, Meidan Ning, Shuyu Zhou, Yu Yang, Chun-Chi Chen, Rey-Ting Guo   +8 more
doaj   +1 more source

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells

BMC Cardiovascular Disorders
Background Nitrogen-containing bisphosphonate(N-BP)had been found to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells (VSMCs), but the mechanism is not clear.
Wei Xu, Lifeng Gong, Weigang Tang, Guoyuan Lu   +3 more
doaj   +1 more source

A cDNA Encoding Farnesyl Pyrophosphate Synthase in White Lupin [PDF]

Plant Physiology, 1995
S, Attucci, S M, Aitken, R K, Ibrahim, P J, Gulick   +3 more
openaire   +2 more sources

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Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase

Bioorganic and Medicinal Chemistry, 1998
Several phosphonate and bisphosphonate analogues of farnesyl pyrophosphate have been prepared for an examination of their ability to inhibit farnesyl protein transferase (FPTase). A Horner-Wadsworth-Emmons condensation of farnesal or geranial with tetraethyl methylenediphosphonate gave the desired vinyl phosphonates, while alkylation of the dimethyl ...
David Wiemer, Sarah Holstein, Raymond J Hohl   +2 more
exaly   +3 more sources

Farnesyl pyrophosphate and geranylgeranyl pyrophosphate synthetases during Cucurbita pepo germination

Phytochemistry, 1974
Abstract Although the geranylgeranyl pyrophosphate synthetase activity was very low compared with farnesyl pyrophosphate synthetase activity on imbibition of pumpkin seed, the former increased markedly and the latter decreased as germination proceeded.
Kyozo Ogura, Shuichi Seto
exaly   +2 more sources