Cwh8 moonlights as a farnesyl pyrophosphate phosphatase and is essential for farnesol biosynthesis in Candida albicans [PDF]
mBioIn the opportunistic pathogen Candida albicans, hyphal growth and virulence factor expression are regulated by environmental and chemical cues. Farnesol is a secreted autoregulatory molecule that represses filamentation.
Daniel J. Gutzmann +7 more
doaj +2 more sources
Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells. [PDF]
FASEB BioadvAdenylyl cyclase 6 (AC6) plays an important role in the generation of cyclic adenosine monophosphate (cAMP) in the lungs. In cystic fibrosis, excessive mucus production and reduced mucociliary clearance create regions of severe hypoxia that can affect cell functions.
Cunnington RH +5 more
europepmc +2 more sources
Effect of farnesol on Candida dubliniensis morphogenesis [PDF]
Letters in Applied Microbiology, 2007 Cell–cell signalling in Candida albicans is a known phenomenon and farnesol was identified as a quorum sensing molecule determining the yeast morphology.
Chan-Tack K.M. +9 more
core +5 more sources
Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis [PDF]
Plant Journal, 2011 SummaryFarnesol, which is toxic to plant cells at high concentrations, is sequentially phosphorylated to farnesyl phosphate and farnesyl diphosphate. However, the genes responsible for the sequential phosphorylation of farnesol have not been identified and the physiological role of farnesol phosphorylation has not been fully elucidated.
A Heather, Fitzpatrick +2 more
exaly +3 more sources
Molecular mechanisms involved in farnesol-induced apoptosis [PDF]
Cancer Letters, 2010 The isoprenoid alcohol farnesol is an effective inducer of cell cycle arrest and apoptosis in a variety of carcinoma cell types. In addition, farnesol has been reported to inhibit tumorigenesis in several animal models suggesting that it functions as a chemopreventative and anti-tumor agent in vivo.
Anton M Jetten
exaly +3 more sources
Ameliorative action of farnesol on cyclophosphamide induced toxicity in mice [PDF]
Journal of HerbMed Pharmacology, 2018 Introduction: Cyclophosphamide is an alkylating agent with antineoplastic and immunosuppressive effects. Acrolein, one of its metabolites, is responsible for different toxic side effects such as oxidative stress, and cell death.
Atefeh Araghi +3 more
doaj +4 more sources
Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol
Molecules, 2018 Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema.
Gautam Sethi +2 more
exaly +3 more sources
Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis
Molecules, 2010 The active multidrug efflux pump (EP) has been described as one of the mechanisms involved in the natural drug resistance of bacteria, such as mycobacteria. As a result, the development of efflux pumps inhibitors (EPIs) is an important topic.
Jing Jin, Na Guo, Lu Yu
exaly +3 more sources
Farnesol stimulates laccase production in Trametes versicolor
Engineering in Life Sciences, 2016 Farnesol, a quorum‐sensing molecule, was used successfully to improve laccase production in submerged cultures of Trametes versicolor. At the optimal farnesol concentration of 60 μM added at the beginning of the culture, the extracellular laccase ...
Jianhua Hu +7 more
doaj +2 more sources
Purification and Characterization of a Novel NAD(P)+-Farnesol Dehydrogenase from Polygonum minus Leaves. [PDF]
PLoS ONE, 2015 Juvenile hormones have attracted attention as safe and selective targets for the design and development of environmentally friendly and biorational insecticides.
Nor-Ain-Shahajar Ahmad-Sohdi +3 more
doaj +1 more source