Results 11 to 20 of about 7,466 (212)
Farnesol-Induced Apoptosis in Candida albicans [PDF]
Antimicrobial Agents and Chemotherapy, 2009 ABSTRACT Farnesol, a precursor in the isoprenoid/sterol pathway, was recently identified as a quorum-sensing molecule produced by the fungal pathogen Candida albicans . Farnesol is involved in the inhibition of germination and biofilm formation by C. albicans and can be cytotoxic at
Shirtliff, Mark E. +7 more
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Biologically Active Fluorescent Farnesol Analogs [PDF]
Chemistry & Biology, 2005 We describe ten polyene analogs of farnesol, typified by 3,7,11-trimethyl-2,4,6,8,10-dodecapentenaldehyde oxime, which preserve the length, cross-section, and approximate hydrophobicity of farnesol. Four of the ten display strong quorum-sensing activity in the human pathogen Candida albicans, with IC(50) values for inhibition of germ-tube formation as ...
Shchepin, Roman +4 more
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Farnesol stimulates laccase production in Trametes versicolor
Engineering in Life Sciences, 2016 Farnesol, a quorum‐sensing molecule, was used successfully to improve laccase production in submerged cultures of Trametes versicolor. At the optimal farnesol concentration of 60 μM added at the beginning of the culture, the extracellular laccase ...
Jianhua Hu +7 more
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Influence of farnesol on the morphogenesis of Aspergillus niger
Journal of Basic Microbiology, 2008 AbstractFarnesol was the first quorum‐sensing regulator to be found in eukaryotic cells. In Candida albicans, a dimorphic fungal human pathogen, farnesol blocks the yeast‐to‐filamentous growth transition. Here we show that in Aspergillus niger farnesol acts as an inhibitor of conidiation: Colonies grown on media containing farnesol were unable to ...
Lorek, Justine +4 more
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Farnesol-Containing Macromolecular Systems for Antibiofilm Strategies
Surfaces, 2020 Farnesol is a natural sesquiterpenoid and an interesting quorum-sensing molecule. Its insolubility in water is the biggest obstacle to its application for bacterial biofilm treatments since it compromises the bioavailability.
Maria Nowacka +2 more
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Cardioprotection by Farnesol: Role of the Mevalonate Pathway
Cardiovascular Drugs and Therapy, 2013 Farnesol is a key metabolite of the mevalonate pathway and known as an antioxidant. We examined whether farnesol treatment protects the ischemic heart.Male Wistar rats were treated orally with 0.2, 1, 5, and 50 mg/kg/day farnesol/vehicle for 12 days, respectively. On day 13, the effect of farnesol treatment on cardiac ischemic tolerance and biochemical
Szűcs, Gergő +8 more
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Biological effects of trans, trans-farnesol in Leishmania amazonensis [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionFarnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers.
Liliane Sena Pinheiro +9 more
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Farnesol, a Potential Efflux Pump Inhibitor in Mycobacterium smegmatis
Molecules, 2010 The active multidrug efflux pump (EP) has been described as one of the mechanisms involved in the natural drug resistance of bacteria, such as mycobacteria. As a result, the development of efflux pumps inhibitors (EPIs) is an important topic.
Jing Jin +10 more
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Ameliorative action of farnesol on cyclophosphamide induced toxicity in mice [PDF]
Journal of HerbMed Pharmacology, 2018 Introduction: Cyclophosphamide is an alkylating agent with antineoplastic and immunosuppressive effects. Acrolein, one of its metabolites, is responsible for different toxic side effects such as oxidative stress, and cell death.
Atefeh Araghi +3 more
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Microbial Biotechnology, 2021 Summary Candida biofilms are tolerant to conventional antifungal therapeutics and the host immune system. The transition of yeast cells to hyphae is considered a key step in C.
Jin‐Hyung Lee +3 more
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