Results 11 to 20 of about 5,807 (179)

Farnesol, the farnesol pathway, and the immune-gut-brain axis. [PDF]

Front Pharmacol
Experimental models and clinical evidence suggest that the gut and the central nervous system (CNS) interact in a multifactorial, bidirectional manner. A third player, the immune system, has recently been identified in these interactions, with research linking the gut microbiome to inflammatory conditions, including those affecting
Gates M, Schumacher SM, Doyle WJ, Sofaly N, Roullet JB, Ochoa-Repáraz J.   +5 more
europepmc   +3 more sources

Fungal-Bacterial Interactions in Polymicrobial Infections: Hidden Threats. [PDF]

Microbiologyopen
ABSTRACT Polymicrobial infections involving fungi and bacteria represent a major and increasingly recognized clinical challenge, in which interkingdom interactions significantly amplify disease severity, antimicrobial resistance, and treatment failure. Rather than passive co‐existence, fungal–bacterial communities form highly coordinated systems driven
Gourabi MJR, Kargar M, Kamali A, Sharahi JY.   +3 more
europepmc   +2 more sources

Farnesol: An approach on biofilms and nanotechnology

Medical Mycology, 2021
Abstract Biofilms are important virulence factor in infections caused by microorganisms because of its complex structure, which provide resistance to conventional antimicrobials. Strategies involving the use of molecules capable of inhibiting their formation and also act synergistically with ...
Adelaide Fernandes Costa, Lívia do Carmo Silva, Andre Correa Amaral   +2 more
openaire   +2 more sources

In vitro and in vivo Effect of Exogenous Farnesol Exposure Against Candida auris

Frontiers in Microbiology, 2020
The spreading of multidrug-resistant Candida auris is considered as an emerging global health threat. The number of effective therapeutic regimens is strongly limited; therefore, development of novel strategies is needed.
Fruzsina Nagy, Fruzsina Nagy, Eszter Vitális, Eszter Vitális, Ágnes Jakab, Andrew M. Borman, Lajos Forgács, Lajos Forgács, Zoltán Tóth, Zoltán Tóth, László Majoros, Renátó Kovács, Renátó Kovács   +12 more
doaj   +1 more source

Enhancement of the antifungal activity of some antimycotics by farnesol and reduction of Candida albicans pathogenicity in a quail model experiment [PDF]

Veterinary World, 2022
Background and Aim: Clinical strains of microorganisms, including pathogenic yeast-like fungi (YLF), are resistant to currently used antifungal agents. Thus, it is relevant to study the combinations of existing antimicrobial drugs and a medicinal extract
Nadezhda Sachivkina, Alexander Senyagin, Irina Podoprigora, Elena Vasilieva, Olga Kuznetsova, Arfenia Karamyan, Alfia Ibragimova, Natalia Zhabo, Maria Molchanova   +8 more
doaj   +1 more source

Farnesol-derived Dicarboxylic Acids in the Urine of Animals Treated with Zaragozic Acid A or with Farnesol [PDF]

Journal of Biological Chemistry, 1997
Farnesyl diphosphate, the substrate for squalene synthase, accumulates in the presence of zaragozic acid A, a squalene synthase inhibitor. A possible metabolic fate for farnesyl diphosphate is its conversion to farnesol, then to farnesoic acid, and finally to farnesol-derived dicarboxylic acids (FDDCAs) which would then be excreted in the urine.
R G, Bostedor, J D, Karkas, B H, Arison, V S, Bansal, S, Vaidya, J I, Germershausen, M M, Kurtz, J D, Bergstrom   +7 more
openaire   +2 more sources

Amino acid substitutions in specific proteins correlate with farnesol unresponsiveness in Candida albicans

BMC Genomics, 2023
Background The quorum-sensing molecule farnesol, in opportunistic yeast Candida albicans, modulates its dimorphic switch between yeast and hyphal forms, and biofilm formation. Although there is an increasing interest in farnesol as a potential antifungal
Sima Mohammadi, Annie Leduc, Steve J. Charette, Jean Barbeau, Antony T. Vincent   +4 more
doaj   +1 more source

Systematic analysis of protein expression in Candida albicans exposed to farnesol

Chinese Medical Journal, 2019
. Background:. The phenotypic switching of Candida spp. plays an important role in the development of vulvovaginal candidiasis (VVC). Farnesol, as a quorum-sensing molecule in Candida albicans, has the ability to prevent yeast-to-hyphal conversion in ...
Feng-Juan Wang, Zhao-Hui Liu, Peng Lyu
doaj   +1 more source

Farnesol Ameliorates Demyelinating Phenotype in a Cellular and Animal Model of Charcot-Marie-Tooth Disease Type 1A

Current Issues in Molecular Biology, 2021
Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous disease affecting the peripheral nervous system that is caused by either the demyelination of Schwann cells or degeneration of the peripheral axon. Currently, there are no treatment options
Na-Young Park, Geon Kwak, Hyun-Myung Doo, Hye-Jin Kim, So-Young Jang, Yun-Il Lee, Byung-Ok Choi, Young-Bin Hong   +7 more
doaj   +1 more source

The Fungal Quorum-Sensing Molecule Farnesol Activates Innate Immune Cells but Suppresses Cellular Adaptive Immunity

mBio, 2015
Farnesol, produced by the polymorphic fungus Candida albicans, is the first quorum-sensing molecule discovered in eukaryotes. Its main function is control of C. albicans filamentation, a process closely linked to pathogenesis.
Ines Leonhardt, Steffi Spielberg, Michael Weber, Daniela Albrecht-Eckardt, Markus Bläss, Ralf Claus, Dagmar Barz, Kirstin Scherlach, Christian Hertweck, Jürgen Löffler, Kerstin Hünniger, Oliver Kurzai   +11 more
doaj   +1 more source