Results 91 to 100 of about 15,452 (211)

Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products

The FEBS Journal, Volume 293, Issue 5, Page 1341-1357, March 2026.
We have converted the only known true bacterial monoterpene synthase, cineole synthase from Streptomyces clavuligerus (bCinS, C10 substrate), to a highly competent sesquiterpene synthase (C15) with a minimum number of rational mutations. By comparison with diterpene synthases (C20), we were then able to bestow diterpene synthase activity on bCinS. This
Nicole G. H. Leferink, Joshua N. Whitehead, Linus O. Johannissen, Nigel S. Scrutton   +3 more
wiley   +1 more source

Transcriptome analysis of Thapsia laciniata rouy provides insights into terpenoid biosynthesis and diversity in apiaceae [PDF]

, 2013
Thapsia laciniata Rouy (Apiaceae) produces irregular and regular sesquiterpenoids with thapsane and guaiene carbon skeletons, as found in other Apiaceae species.
Acquadro, Avato, Bak, Bjørn Dueholm, Bouvier, Cavagnaro, Christensen, Christoph Sensen, Cool, Corinna Weitzel, Damian Drew, De Kraker, Drew, Drew, Eddy, Gaasterland, Guindon, Hegnauer, Hemmerlin, Henrik Simonsen, Holub, Ikezawa, Iorizzo, Kotchoni, Mao, Martin, Meisel, Moriya, Nelson, Nguyen, Nørholm, Ogata, Pickel, Polichuk, Ro, Rouy, Rubal, Ruhlman, Schulz, Simonsen, Smitt, Sui, Tang, Teoh, Tholl, Thulasiram, Tutin, Weitzel, Ye Zhang, Yu, Zerbino   +50 more
core   +2 more sources

Purification and characterization of farnesyl pyrophosphate synthase from Capsicum annuum

FEBS Letters, 1990
Faraesyl pyrophosphate synthase (FPP) displaying dimethylallyl transferase activity (EC 2.5.1.1) and geranyl transferase activity (EC 2.5.1.10) was purified from Capsicum fruits. This prenyltransferase has a molecular mass of 89000 ± 5000 Da resulting from the association of two apparently identical subunits having a molecular mass of 43000 ± 2000 Da ...
Hugueney, Philippe, Camara, Bilal
openaire   +2 more sources

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency [PDF]

, 1871
Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be fully elucidated ...
Tricarico, Paola Maura, Romeo, Alessandra, Gratton, Rossella, Crovella, Sergio, Celsi, Fulvio   +4 more
core   +2 more sources

An Examination of the Effects of Atorvastatin and Parathyroid Hormone on Osteoblast Activity [PDF]

, 2014
HMG-CoA reductase inhibitors, also known as statins, are a ubiquitous class of medication used for lowering cholesterol. In-vitro and animal studies have suggested that statins can activate osteoblast differentiation and have anabolic effects on bones ...
Lam, InLok, Lull, Melinda E., Traina, Andrea   +2 more
core   +1 more source

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +1 more source

The Mevalonate Pathway Is Indispensable for Adipocyte Survival

iScience, 2018
Summary: The mevalonate pathway is essential for the synthesis of isoprenoids and cholesterol. Adipose tissue is known as a major site for cholesterol storage; however, the role of the local mevalonate pathway and its synthesized isoprenoids remains ...
Yu-Sheng Yeh, Huei-Fen Jheng, Mari Iwase, Minji Kim, Shinsuke Mohri, Jungin Kwon, Satoko Kawarasaki, Yongjia Li, Haruya Takahashi, Takeshi Ara, Wataru Nomura, Teruo Kawada, Tsuyoshi Goto   +12 more
doaj   +1 more source

Targeting Metastatic Breast Cancer with Statin Drugs and CoQ10 [PDF]

, 2018
Statin drugs are commonly prescribed to lower cholesterol levels in patients, but recently statins have been under investigation as a potential anti-cancer drug. Statins are HMG-CoA reductase inhibitors and subsequently inhibit the mevalonate pathway and
Thrasher, Jacob
core   +1 more source

Pleiotropic effects of statins

Indian Journal of Endocrinology and Metabolism, 2015
Statins or 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors not only prevents the synthesis of cholesterol biosynthesis but also inhibits the synthesis of essential isoprenoid intermediates such as farnesyl pyrophosphate, geranylgeranyl
Narasaraju Kavalipati, Jay Shah, Ananthraman Ramakrishan, Hardik Vasnawala   +3 more
doaj   +1 more source

Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors.

PLoS ONE, 2014
The yeast Xanthophyllomyces dendrorhous synthesizes the carotenoid astaxanthin, which has applications in biotechnology because of its antioxidant and pigmentation properties.
Jennifer Alcaíno, Ignacio Romero, Mauricio Niklitschek, Dionisia Sepúlveda, María Cecilia Rojas, Marcelo Baeza, Víctor Cifuentes   +6 more
doaj   +1 more source