Results 91 to 100 of about 296 (134)

The formation of cyclic sesquiterpenes from farnesyl pyrophosphate by prenyltransferase

Archives of Biochemistry and Biophysics, 1981
Abstract Prenyltransferase, which normally catalyzes the 1′-4 condensation which is the basic polymerization of polyterpenoid and cholesterol biosynthesis, also mediates a pyrophosphate-dependent solvolysis of its substrates. We had previously shown that this was an aberration of the normal reaction and that dimethylallyl alcohol and geraniol were ...
A, Saito, H C, Rilling
openaire   +2 more sources

Farnesyl Pyrophosphate Synthase Is the Molecular Target of Nitrogen-Containing Bisphosphonates

Biochemical and Biophysical Research Communications, 1999
Bisphosphonates (Bps), inhibitors of osteoclastic bone resorption, are used in the treatment of skeletal disorders. Recent evidence indicated that farnesyl pyrophosphate (FPP) synthase and/or isopentenyl pyrophosphate (IPP) isomerase is the intracellular target(s) of bisphosphonate action. To examine which enzyme is specifically affected, we determined
Beek, E. van, Pieterman, E., Cohen, L., Löwik, C., Papapoulos, S.   +4 more
openaire   +3 more sources

Aristolochene biosynthesis and enzymatic cyclization of farnesyl pyrophosphate

Journal of the American Chemical Society, 1989
Proposition d'un schema reactionnel concernant la biosynthese d'un sesquiterpene, en l'occurrence l'aristolochene, chez Aspergillus terrus.
David E. Cane, P. C. Prabhakaran, E. J. Salaski, Paul H. M. Harrison, Hiroshi Noguchi, Bernard J. Rawlings   +5 more
openaire   +1 more source

Synthesis of pyrophosphonic acid analogues of farnesyl pyrophosphate

Tetrahedron, 1995
The synthesis of four new analogues (i.e. 3-6) of farnesyl pyrophosphate (FPP), which may function as inhibitor of squalene synthase, is described. Compounds 3 and 4 were readily accessible by reaction of farnesal with diethyl phosphite or dimethyl lithiomethylphosphonate, respectively, followed by condensation of the resulting alcohols with diethyl ...
Valentijn, A.R.P.M., Berg, O. van den, Marel, G.A. van der, Cohen, L.H., Boom, J.H. van   +4 more
openaire   +2 more sources

Mechanism of the biosynthesis of squalene from farnesyl pyrophosphate

Tetrahedron, 1987
Abstract The biosynthesis of squalene (1) from farnesyl pyrophosphate (2) has been studied by carrying out calculations for models. The suggested mechanism involves initial allylic attack on 2 by the enzyme, probably by the trapping of farnesyl cation, followed by S N 2' reaction with a second molecule of 2 to form a π complex which is deprotonated ...
Michael J.S. Dewar, James M. Ruiz
openaire   +1 more source

Enzymatic synthesis of new farnesyl pyrophosphate homologues

Journal of the Chemical Society, Chemical Communications, 1972
3-Ethylbut-3-enyl pyrophosphate acts as a substrate for farnesyl pyrophosphate synthetase in place of isopentenyl pyrophosphate, to give farnesyl pyrophosphate homologues.
Kyozo Ogura, Tanetoshi Koyama, Shuichi Seto   +2 more
openaire   +1 more source

Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

Chemical Communications, 2010
The mevalonate pathway is an important drug target for the treatment of cancer and cardiovascular disease. We synthesized and studied a new type of nitrogen-containing bisphosphonate analogs and developed a sensitive end point assay method for enzyme FPPS, which was used for inhibitor screening.
Jinbo, Gao, Xiusheng, Chu, Yongge, Qiu, Long, Wu, Yuqin, Qiao, Jiasheng, Wu, Ding, Li   +6 more
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Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase

Expert Opinion on Drug Discovery, 2016
Farnesyl pyrophosphate synthase (FPPS) catalyzes the condensation of isopentenyl diphosphate with dimethylallyl diphosphate to give rise to one molecule of geranyl diphosphate, which on a further reaction with another molecule of isopentenyl diphosphate forms the 15-carbon isoprenoid farnesyl diphosphate.
Rodriguez, Juan Bautista, Falcone, Bruno Nicolas, Szajnman, Sergio Hernan   +2 more
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Substrate specificity of farnesyl pyrophosphate synthetase

Journal of the American Chemical Society, 1972
T, Nishino, K, Ogura, S, Seto
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Formation of 16,16'-bisnorgeranylgeranyl pyrophosphate by farnesyl pyrophosphate synthetase

Journal of the American Chemical Society, 1971
Shuichi Seto, Tokuzo Nishino, Kyozo Ogura   +2 more
openaire   +1 more source