Results 91 to 100 of about 9,807 (200)

Synthesis and Activity of Fluorescent Isoprenoid Pyrophosphate Analogues

, 2016
New fluorescent analogues of farnesol and geranylgeraniol have been prepared and then converted to the corresponding pyrophosphates. These analogues incorporate anthranylate or dansyl-like groups anchored to the terpenoid skeleton through amine bonds ...
Raymond J. Hohl (3032028), David F. Wiemer (1309671), Sarah A. Holstein (414571), Troy S. Kleckley (2666404), Andrew J. Wiemer (1831930), Kim (3208551)   +5 more
core   +1 more source

Pleiotropic effects of statins

Indian Journal of Endocrinology and Metabolism, 2015
Statins or 3-hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors not only prevents the synthesis of cholesterol biosynthesis but also inhibits the synthesis of essential isoprenoid intermediates such as farnesyl pyrophosphate, geranylgeranyl
Narasaraju Kavalipati, Jay Shah, Ananthraman Ramakrishan, Hardik Vasnawala   +3 more
doaj   +1 more source

Farnesyl Pyrophosphate Is a Novel Transcriptional Activator for a Subset of Nuclear Hormone Receptors

, 2007
In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-β (TRβ) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might function as an ...
Goyanka, Ritu, Schapira, Matthieu, Samuels, Herbert H, Cardozo, Timothy, Tomic-Canic, Marjana, Das, Sharmistha   +5 more
core   +1 more source

Inhibition of farnesyl pyrophosphate synthase alleviates cardiomyopathy in diabetic rat. [PDF]

Cell Cycle, 2023
Liu X, Liu Y, Tang L, Du C.
europepmc   +1 more source

Allosteric non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase identified by fragment-based discovery

, 2010
Bisphosphonates are potent inhibitors of farnesyl pyrophosphate synthase (FPPS) and are highly efficacious in the treatment of bone diseases such as osteoporosis, Paget´s disease and tumor-induced osteolysis.
Francis Bitsch, Strauss, Andre, Marjo Götte, Geiser, Martin, Roddy, Thomas, Glickman, Fraser, Wolfgang Jahnke, Hemmig, Rene, Xavier Pellé, Jonathan R Green, Cotesta, Simona, Marzinzik, Andreas, Thomas P Roddy, Green, Jonathan, René Hemmig, Chrystèle Henry, Sylvie Lehmann, Bitsch, Francis, Stout, Steven, Andreas Marzinzik, Henry, Christelle, Martin Geiser, J Fraser Glickman, André Strauss, Steven J Stout, Jean-Michel Rondeau, Rondeau, Jean-Michel, Goette, Marjo, Lehmann, Sylvie, Simona Cotesta, Jahnke, Wolfgang, Pelle, Xavier   +31 more
core   +1 more source

Functional analysis of Pogostemon cablin farnesyl pyrophosphate synthase gene and its binding transcription factor PcWRKY44 in regulating biosynthesis of patchouli alcohol. [PDF]

Front Plant Sci, 2022
Wang X, Tang Y, Huang H, Wu D, Chen X, Li J, Zheng H, Zhan R, Chen L.   +8 more
europepmc   +1 more source

Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene.

, 1993
The prenyltransferases are a class of enzymes involved in the synthesis of sterol and nonsterol isoprene compounds. We report here the chromosomal mapping of nine loci in the mouse that hybridize to the cDNA for the enzyme farnesyl pyrophosphate ...
Taylor, B A, Lusis, A J, Quon, D, Mohandas, T, Diep, A, Andalibi, A   +5 more
core  

The role of protein prenylation inhibition through targeting FPPS by zoledronic acid in the prevention of renal fibrosis in rats

Scientific Reports
Renal fibrosis (RF) represents the most widespread pathological condition in chronic kidney disease (CKD). Recently, protein prenylation has been implicated in the fibrosis’s progression. The research examined the renoprotective effect of zoledronic acid
Reham Hussein Mohamed, Dina S. Abdelrahim, Nesma Hussein Abdel Hay, Nesma Mohamed Fawzy, Doaa Karem M. M., Dalia Ahmed Yousef Yehia, Omnia M. AbdelMaksoud, Yomna M. Tamim   +7 more
doaj   +1 more source

Probing the Structures of Leishmanial Farnesyl Pyrophosphate Synthases: Homology Modeling and Docking Studies

, 2016
Leishmania donovani and Leishmania major farnesyl pyrophosphate synthase (LdFPPS and LmFPPS) are potential targets for the development of antileishmanial therapy. The protein sequence for LdFPPS was recently elucidated in our laboratory.
Mitchell A. Avery (239950), Prasenjit Mukherjee (2041477), Prashant V. Desai (239948), Anuradha Srivastava (2437303), Babu L. Tekwani (1328517)   +4 more
core   +1 more source

Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages

Journal of Bacteriology
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M.
Matheus da Silva Rocha, Antônio Marcos Rodrigues Pereira, Plínio Marcos Freire dos Santos, André Alves Dias, Melissa Pontes Pereira, Patrícia Sammarco Rosa, Daniele F. F. Bertoluci, John T. Belisle, Fabricio da Mota Ramalho Costa, Cristiana Santos de Macedo, Maria Cristina Vidal Pessolani, Marcia Berrêdo-Pinho   +11 more
doaj   +1 more source