Results 101 to 110 of about 9,807 (200)

Structural Evidence of N6‑Isopentenyladenosine As a New Ligand of Farnesyl Pyrophosphate Synthase

, 2016
N6-isopentenyladenosine (i6A), a modified nucleoside belonging to the cytokinin family, has shown in humans many biological actions, including antitumoral effects through the modulation of the farnesyl pyrophosphate synthase (FPPS) activity.
Mario Scrima (680670), Gianluigi Lauro (1355385), Anna Maria D’Ursi (654019), Sara Di Marino (1745086), Paola Picardi (1745083), Ettore Novellino (333902), Raffaele Riccio (1355394), Manuela Grimaldi (680669), Patrizia Gazzerro (409139), Maurizio Bifulco (409140), Giuseppe Bifulco (186812), Alessandra Tosco (484379)   +11 more
core   +1 more source

Density functional theory calculation of interaction between bisphosphate and farnesyl pyrophosphate synthase

, 2010
Bisphosphonates (BPs) are the most widely used and effective treatment for osteoporosis and Pagets disease of the bone. To date, a number of BPs-namely alendronate, risedronate, and minodronate-have been launched to market.
Kazuki Ohno, Makoto Takeuchi, Yohsuke Hagiwara, Masaya Orita, Kenichi Mori   +4 more
core   +1 more source

Development of a Komagataella phaffii cell factory for sustainable production of ( +)-valencene

Microbial Cell Factories
Background Sesquiterpene ( +)-valencene is a characteristic aroma component from sweet orange fruit, which has a variety of biological activities and is widely used in industrial manufacturing of food, beverage and cosmetics industries.
Jintao Cheng, Jiali Chen, Dingfeng Chen, Baoxian Li, Chaozhi Wei, Tao Liu, Xiao Wang, Zhengshun Wen, Yuanxiang Jin, Chenfan Sun, Guiling Yang   +10 more
doaj   +1 more source

The Enigma of Sponge-Derived Terpenoid Isothiocyanate–Thiocyanate Pairs: A Biosynthetic Proposal

Marine Drugs
The co-occurrence of rare terpenoid thiocyanates (R-SCN), structurally similar to their more common isothiocyanate isomers (R-NCS), poses an enigma: how does the accepted path, terpenyl cation R+ → R-NC → R-NCS, accommodate R-SCN?
Tadeusz F. Molinski
doaj   +1 more source

Discovery of Novel Allosteric, Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding

, 2015
Farnesyl pyrophosphate synthase (FPPS) is an established target for bone diseases, but also shows promise as an anticancer and anti-infective drug target.
Bold, Guido, René Amstutz, Marjo Götte, Roddy, Thomas, Glickman, Fraser, Stauffer, Frederic, Silvio Ofner, Wolfgang Jahnke, Xavier Pellé, Marzinzik, Andreas, Cotesta, Simona, Ofner, Silvio, Sylvie Lehmann, Stout, Steven, J. Constanze D. Hartwieg, Jean‐Michel Rondeau, Amstutz, Rene, Henry, Christelle, Andreas L. Marzinzik, J. Fraser Glickman, Bourgier, Emmanuelle, Guido Bold, Zimmermann, Johann, Johann Zimmermann, Thomas Zoller, Hartwieg, Constanze, Frédéric Stauffer, Steven J. Stout, Zoller, Thomas, Rondeau, Jean-Michel, Goette, Marjo, Thomas P. Roddy, Armin Widmer, Lehmann, Sylvie, Emmanuelle Bourgier, Christelle Henry, Simona Cotesta, Widmer, Armin, Pelle, Xavier, Jahnke, Wolfgang   +39 more
core   +1 more source

Influence of Nutrient (NPK) Factors on Growth, and Pharmacodynamic Component Biosynthesis of Atractylodes chinensis: An Insight on Acetyl-CoA Carboxylase (ACC), 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR), and Farnesyl Pyrophosphate Synthase (FPPS) Signaling Responses. [PDF]

Front Plant Sci, 2022
Sun J, Luo H, Jiang Y, Wang L, Xiao C, Weng L.   +5 more
europepmc   +1 more source

Regulation of Steroidal Alkaloid Biosynthesis in Bulbs of Fritillaria thunbergii Miq. By Shading and Potassium Application: Integrating Transcriptomics and Metabolomics Analyses

Biology
Fritillaria thunbergii Miq., a medicinal plant rich in steroidal alkaloids, produces bulbs that clear heat, resolve phlegm, and detoxify. However, excessive yield-oriented cultivation has reduced the number of F.
Jia Liu, Zixuan Zhu, Leran Wang, Qiang Yuan, Honghai Zhu, Xiaoxiao Sheng, Kejie Zhang, Bingbing Liang, Huizhen Jin, Shumin Wang, Wenjun Weng, Hui Wang, Ning Sui   +12 more
doaj   +1 more source

Novel inhibitors of the human Farnesyl Pyrophosphate Synthase

, 2013
Farnesyl pyrophosphate synthase (FPPS) occupies the first branching point of the mevalonate pathway, an important biosynthetic route that provides essential lipid molecules, such as steroids and isoprenoids, in mammalian cells.
De Schutter, Joris
core  

Molecular insights into a distinct class of terpenoid cyclases

Nature Communications
Terpenoid cyclases (TCs) account for the synthesis of the most widespread and diverse natural compounds. A sesquiterpene cyclase termed BcABA3 from an abscisic acid-producing fungus Botrytis cinerea that yields (2Z,4E)-α-ionylideneethane but lacks ...
Siyu Li, Jian-Wen Huang, Jian Min, Hao Li, Meidan Ning, Shuyu Zhou, Yu Yang, Chun-Chi Chen, Rey-Ting Guo   +8 more
doaj   +1 more source

Structural Evidence ofN6-Isopentenyladenosine As a New Ligand of Farnesyl Pyrophosphate Synthase

, 2014
N6-isopentenyladenosine (i6A), a modified nucleoside belonging to the cytokinin family, has shown in humans many biological actions, including antitumoral effects through the modulation of the farnesyl pyrophosphate synthase (FPPS) activity.
TOSCO, ALESSANDRA, Anna Maria D’Ursi, RICCIO, Raffaele, SCRIMA, MARIO, Manuela Grimaldi, Sara Di Marino, LAURO, GIANLUIGI, PICARDI, PAOLA, Alessandra Tosco, Gianluigi Lauro, D'URSI, Anna Maria, Mario Scrima, Patrizia Gazzerro, Raffaele Riccio, BIFULCO, Giuseppe, Sara Di Marino, Paola Picardi, Ettore Novellino, GRIMALDI, MANUELA, Maurizio Bifulco, Giuseppe Bifulco, GAZZERRO, Patrizia, Ettore Novellino, BIFULCO, Maurizio   +23 more
core   +1 more source