Results 81 to 90 of about 296 (134)

Farnesyl pyrophosphate synthase

2021
Harry Morrison
exaly   +2 more sources

Enzymic conversion of farnesyl pyrophosphate to squalene

Archives of Biochemistry and Biophysics, 1966
Abstract Squalene synthetase of pig liver has been solubilized and partially purified. This enzyme has a pH optimum of 7.4 and a K m value of 5 × 10 −7 M for farnesyl pyrophosphate. A divalent metal ion, Mg ++ or Mn ++ , and NADPH are required for the conversion of farnesyl pyrophosphate to squalene.
G, Krishna, H W, Whitlock, D H, Feldbruegge, J W, Porter   +3 more
openaire   +2 more sources

Photoaffinity Analogues of Farnesyl Pyrophosphate Transferable by Protein Farnesyl Transferase

Journal of the American Chemical Society, 2002
Farnesylation is a posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins in a reaction catalyzed by protein farnesyltransferase (FTase). We synthesized analogues (3-6) of farnesyl pyrophosphate (FPP) to probe the range of modifications possible to the FPP ...
Kareem A H, Chehade, Katarzyna, Kiegiel, Richard J, Isaacs, Jennifer S, Pickett, Katherine E, Bowers, Carol A, Fierke, Douglas A, Andres, H Peter, Spielmann   +7 more
openaire   +2 more sources

FORMATION OF A NONALLYLIC HOMONERYL PYROPHOSPHATE BY FARNESYL PYROPHOSPHATE SYNTHETASE

Chemistry Letters, 1975
Abstract The reaction of 4-methylpent-4-enyl pyrophosphate (1) with dimethylallyl pyrophosphate (2) catalyzed by farnesyl pyrophosphate synthetase (prenyltransferase) results in an exclusive cis condensation to give a nonallylic homoneryl pyrophosphate (3).
Akio Saito, Kyozo Ogura, Shuichi Seto
openaire   +1 more source

Expression of farnesyl pyrophosphate synthase is increased in diabetic cardiomyopathy

Cell Biology International, 2021
AbstractFarnesyl pyrophosphate synthase (FPPS)‐catalyzed isoprenoid intermediates are involved in diabetic cardiomyopathy. This study investigated the specific role of FPPS in the development of diabetic cardiomyopathy. We demonstrated that FPPS expression was elevated in both in vivo and in vitro models of diabetic cardiomyopathy.
Zhengwei Li, Jiefang Zhang, Min Wang, Fuyu Qiu, Chongyin Jin, Guosheng Fu   +5 more
openaire   +2 more sources

Inhibition of squalene synthetase by farnesyl pyrophosphate analogs

Journal of Medicinal Chemistry, 1977
The pyrophosphates of the following farnesol analogues have been synthesized: 2-methylfarnesol; 7,11-dimethyl-3-ethyl-2,6,10-dodecatrien-1-ol; 3-demethylfarnesol; 4-methylthiofarnesol; 7,11-dimethyl-3-iodo-2,6,10-dodecatrien-1-ol; 7,11-dimethyl02-iodo-2,6,10-dodecatrien-1-ol; 7,11-dimethyldodeca-6,10-dien-2-yn-1-ol; phytol; 3,7,11-trimethyl-2-dodecen-1-
P R, de Montellano, J S, Wei, R, Castillo, C K, Hsu, A, Boparai   +4 more
openaire   +2 more sources

Properties of farnesyl pyrophosphate synthetase of pig liver

Archives of Biochemistry and Biophysics, 1965
Abstract The isolation and partial purification of farnesyl pyrophosphate synthetase of pig liver are described. This enzyme does not have isopentenyl pyrophosphate isomerase, geranyl pyrophosphate synthetase, or geranyl geranyl pyrophosphate synthetase activities.
C R, Benedict, J, Kett, J W, Porter
openaire   +2 more sources

Brain Isoprenoids Farnesyl Pyrophosphate and Geranylgeranyl Pyrophosphate are Increased in Aged Mice

Molecular Neurobiology, 2012
The mevalonate/isoprenoids/cholesterol pathway has a fundamental role in the brain. Increasing age could be associated with specific changes in mevalonate downstream products. Other than age differences in brain cholesterol and dolichol levels, there has been little if any evidence on the short-chain isoprenoids farnesylpyrophosphate (FPP) and ...
Gero P, Hooff, W Gibson, Wood, Ji-Hyun, Kim, Urule, Igbavboa, Wei-Yi, Ong, Walter E, Muller, Gunter P, Eckert   +6 more
openaire   +2 more sources

A novel approach towards the synthesis of pyrophosphate analogues of farnesyl pyrophosphate

Recueil des Travaux Chimiques des Pays-Bas, 1994
AbstractThe synthesis of two new analogues (i.e. 3 and 4) of farnesyl pyrophosphate (FPP) containing a phosphonophosphate and a phosphonophosphonate moiety was accomplished via the phosphonomorpholidate. The latter was easily obtained by treatment of a phosphonic chloride with morpholine.
Valentijn, A.R.P.M., Berg, O. van den, Marel, G.A. van der, Cohen, L.H., Boom, J.H. van   +4 more
openaire   +2 more sources

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase

Bioorganic & Medicinal Chemistry Letters, 2010
A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented.
Joris W, De Schutter, Serge, Zaretsky, Sarah, Welbourn, Arnim, Pause, Youla S, Tsantrizos   +4 more
openaire   +2 more sources