Results 81 to 90 of about 9,807 (200)

α-Phosphono Lactone Analogues of Farnesyl Pyrophosphate:  An Asymmetric Synthesis via Ring-Closing Metathesis

, 2016
An α-phosphono lactone derivative of farnesol has been prepared, in both racemic and nonracemic forms, to provide a new type of farnesyl pyrophosphate analogue.
David F. Wiemer (1309671), Yanming Du (822990)   +1 more
core   +1 more source

Strong Implications From Small Deviations in Labeling Patterns: The Mechanism of Burkholderia gladioli Pacifigorgiadiene Synthase

Chemistry – A European Journal, Volume 32, Issue 16, 25 April 2026.
The mechanism of pacifigorgiadiene synthase from Burkholderia gladioli was investigated through isotopic labeling experiments and DFT calculations. The results revealed an unexpected labeling pattern which appeared to be different in the main and the side products, requiring unprecedented mechanistic explanations, including a “break‐flip‐cyclise ...
Zhiyong Yin, Zhehui Hu, Xiyuan He, Juan Xu, Bernd Goldfuss, Jeroen S. Dickschat, Guangkai Bian   +6 more
wiley   +1 more source

Synthesis of high specific activity (1- sup 3 H) farnesyl pyrophosphate

, 1991
The synthesis of tritiated farnesyl pyrophosphate with high specific activity is reported. trans-trans Farnesol was oxidized to the corresponding aldehyde followed by reduction with lithium aluminium tritide (5%-{sup 3}H) to give trans-trans (1-{sup 3}H ...
Williams, P. G., Morimoto, H., Saljoughian, M.   +2 more
core  

A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli

, 1996
A previously described cembranolide diterpene from Lobophytum cristagalli was identified as a potent (lC so 0.15 11M) inhibitor of farnesyl protein transferase (FPT).
Coval, S. J., Patel, Mahesh, Bishop, W. R., Patton, R. W., Linda James, McPhail, A. T., Marnie L. Rothofsky, Robert W. Patton, Stanley L. Lin, Petrin, J. M., Stephen J. Coval, Andrew T. McPhail, W. Robert Bishop, Rothofsky, M. L., Lin, S. L., Reed, John K., John K. Reed, James, L., Mahesh Patel, Joanne M. Petrin   +19 more
core   +1 more source

Biosynthesis and Structure of a New Intermediate between Farnesyl Pyrophosphate and Squalene

Journal of Biological Chemistry, 1969
Abstract The intermediate, discovered by Rilling, between farnesyl pyrophosphate and squalene was synthesized in milligram quantities with yeast subcellular particles from farnesyl-14C-pyrophosphate and from farnesyl-1-3H2-14C-pyrophosphate. The 3H:14C ratio in the new squalene precursor was found to be identical with that in the farnesyl pyrophosphate,
G, Popják, J, Edmond, K, Clifford, V, Williams   +3 more
openaire   +2 more sources

Enhanced Triterpene Accumulation in Panax ginseng Hairy Roots Overexpressing Mevalonate-5-pyrophosphate Decarboxylase and Farnesyl Pyrophosphate Synthase

, 2016
To elucidate the function of mevalonate-5-pyrophosphate decarboxylase (MVD) and farnesyl pyrophosphate synthase (FPS) in triterpene biosynthesis, the genes governing the expression of these enzymes were transformed into Panax ginseng hairy roots. All the
Soo-Un Kim (1734889), Sang Un Park (415822), Yeon Bok Kim (415817), Sanghyun Lee (179163), Yong-Kyoung Kim (1734892), Md Romij Uddin (422070)   +5 more
core   +1 more source

Photoactive Analogs of Farnesyl Pyrophosphate Containing Benzoylbenzoate Esters:  Synthesis and Application to Photoaffinity Labeling of Yeast Protein Farnesyltransferase

, 2016
Farnesyl pyrophosphate (FPP) is involved in a large number of cellular processes including the prenylation of transforming mutants of Ras proteins implicated in cancer.
Valerie A. Weller (3004026), Igor Gaon (3037467), Rebecca L. Edelstein (2945433), Satinder K. Singh (1332018), Mark D. Distefano (559344), Tammy C. Turek (3037464)   +5 more
core   +1 more source

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +1 more source

The Mevalonate Pathway Is Indispensable for Adipocyte Survival

iScience, 2018
Summary: The mevalonate pathway is essential for the synthesis of isoprenoids and cholesterol. Adipose tissue is known as a major site for cholesterol storage; however, the role of the local mevalonate pathway and its synthesized isoprenoids remains ...
Yu-Sheng Yeh, Huei-Fen Jheng, Mari Iwase, Minji Kim, Shinsuke Mohri, Jungin Kwon, Satoko Kawarasaki, Yongjia Li, Haruya Takahashi, Takeshi Ara, Wataru Nomura, Teruo Kawada, Tsuyoshi Goto   +12 more
doaj   +1 more source

Thermodynamic Evaluation of the Binding of Bisphosphonates to Human Farnesyl Pyrophosphate Synthase

Chemical and Pharmaceutical Bulletin, 2014
Bisphosphonates (BPs) are the drug of choice for treating bone diseases such as osteoporosis, Paget's disease, and metastatic bone disease. BPs with nitrogen-containing side chains (N-BPs) are known to act as inhibitors for farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway.
Kawasaki, Yuko, Sekiguchi, Mitsuhiro, Kawasaki, Masashi, Hirakura, Yutaka   +3 more
openaire   +3 more sources