Results 31 to 40 of about 30,985 (250)
Management of Mevalonate Kinase Deficiency: A Pediatric Perspective
Frontiers in Immunology, 2020 Background: Mevalonate kinase deficiency (MKD) is an inborn error of metabolism leading to a syndrome characterized by recurrent inflammation. This clinically manifests itself as fever and can be accompanied by gastrointestinal symptoms, oral ulcers ...
Jerold Jeyaratnam, Joost Frenkel
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A move in response to starvation
eLife, 2021 When a yeast cell runs out of fuel, it can increase the flux through a central metabolic pathway by simply changing the location of an enzyme.
Rebecca Martina Fausten, Maria Bohnert
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Effect of ethanol on cholesterol and bile acid metabolism
Journal of Lipid Research, 1972 Ethanol feeding increased significantly levels of hepatic esterified cholesterol and serum free and esterified cholesterol in rats. Incorporation of intraperitoneally administered [14C]acetate into cholesterol was significantly increased.
A.F. Lefèvre, L.M. DeCarli, C.S. Lieber
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Biomolecules, 2021 Mevalonate Kinase Deficiency (MKD) is a rare inborn disease belonging to the family of periodic fever syndromes. The MKD phenotype is characterized by systemic inflammation involving multiple organs, including the nervous system.
Erika Rimondi +5 more
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Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways [PDF]
, 2022 Mevalonate 3,5-bisphosphate decarboxylase is involved in the recently discovered Thermoplasma-type mevalonate pathway. The enzyme catalyzes the elimination of the 3-phosphate group from mevalonate 3,5-bisphosphate as well as concomitant decarboxylation ...
Vinokur, Jeffrey +11 more
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Biocatalytic asymmetric phosphorylation of mevalonate
, 2014 The excellent selectivity of the mevalonate kinase-catalyzed phosphorylation of mevalonate simplifies lengthy multi-step routes to (R)-mevalonate-5-phosphate to a one-step biocatalytic reaction, because the phosphate group can be transferred directly and
Hellriegel, C. +5 more
core +2 more sources
Molecules, 2021 Globally, Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders associated with cognitive decline and memory deficits due to beta-amyloid deposition (Aβ) and tau protein hyperphosphorylation. To date, approximately
Rajib Das +7 more
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Journal of Lipid Research, 1982 Yields of (14)CO(2) from [2-(14)C]mevalonate and [5-(14)C]mevalonate have been used by others to estimate the activity of the non-sterol-forming pathway, also called the mevalonate shunt pathway, and yields of (14)C in sterols have been used to estimate ...
P S Brady +4 more
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Determination of mevalonate in blood plasma in man and rat. Mevalonate “tolerance” tests in man.
Journal of Lipid Research, 1979 A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation of ...
G Popják +5 more
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The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Frontiers in Oncology, 2021 A hallmark of cancer cells includes a metabolic reprograming that provides energy, the essential building blocks, and signaling required to maintain survival, rapid growth, metastasis, and drug resistance of many cancers.
Borja Guerra +5 more
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