Results 1 to 10 of about 17,106 (263)

Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis

Memórias do Instituto Oswaldo Cruz, 2022
A significant percentage of exogenous cholesterol was found in promastigotes and amastigotes of all studied species of Leishmania, suggesting a biological role for this molecule. Previous studies have shown that promastigotes of Leishmania uptake more low-density lipoprotein (LDL) particles under pharmacological pressure and are more susceptible to ...
Valter Viana Andrade-Neto, Pedro Paulo de Abreu Manso, Miria Gomes Pereira, Nuccia Nicole Theodoro de Cicco, Georgia Corrêa Atella, Marcelo Pelajo-Machado, Rubem Figueiredo Sadok Menna-Barreto, Eduardo Caio Torres-Santos   +7 more
doaj   +5 more sources

Antibacterial Effect of Some Eukaryotic Sterol Biosynthesis Inhibitors

Advanced Biomedical Research, 2022
Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in bacteria.
Ghasem Arjmand, Mohammad Reza Haeri
openaire   +4 more sources

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. [PDF]

PLoS Pathogens, 2018
Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans.
Wenxu Zhou, Anjan Debnath, Gareth Jennings, Hye Jee Hahn, Boden H Vanderloop, Minu Chaudhuri, W David Nes, Larissa M Podust   +7 more
doaj   +3 more sources

Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast. [PDF]

Cells
Sterols and sphingolipids assemble into specialized membrane microdomains that are essential for membrane function, protein sorting, and signal transduction. Although coordinated regulation between sterol and sphingolipid metabolic pathways has long been
Barone F, Cottier S, Stribny J, Visentin M, Schneiter R, Lone MA.   +5 more
europepmc   +2 more sources

Post-lanosterol inhibition profile based classification of commonly used prescription medications. [PDF]

Transl Psychiatry
Cholesterol is an essential structural component of all cells, and the sterol biosynthetic pathway provides critical precursors for essential homeostatic molecules. Sterol biosynthesis can be disrupted by pathogenic variants in genes, as well as commonly
Tallman KA, Anderson AC, Mirnics K, Porter NA, Korade Z.   +4 more
europepmc   +2 more sources

Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

Microorganisms, 2022
The sterol biosynthesis pathway of Leishmania spp. is used as a pharmacological target; however, available information about the mechanisms of the regulation and remodeling of sterol-related genes is scarce.
Thais Tenorio Soares Fujii, Pollyanna Stephanie Gomes, Rubens Lima do Monte-Neto, Daniel Claudio de Oliveira Gomes, Marc Ouellette, Eduardo Caio Torres-Santos, Valter Viana Andrade-Neto, Herbert Leonel de Matos Guedes   +7 more
doaj   +2 more sources

Altering Sterol Composition Implied That Cholesterol Is Not Physiologically Associated With Diosgenin Biosynthesis in Trigonella foenum-graecum

Frontiers in Plant Science, 2021
Diosgenin serves as an important precursor of most steroidal drugs in market. Cholesterol was previously deemed as a sterol origin leading to diosgenin biosynthesis.
Liyang Cao, Zilin Zhou, Zilin Zhou, Jia Sun, Changfu Li, Changfu Li, Yansheng Zhang, Yansheng Zhang   +7 more
doaj   +1 more source

Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis

Biomolecules, 2023
The concurrent use of several medications is a common practice in the treatment of complex psychiatric conditions. One such commonly used combination is aripiprazole (ARI), an antipsychotic, and trazodone (TRZ), an antidepressant.
Zeljka Korade, Allison Anderson, Marta Balog, Keri A. Tallman, Ned A. Porter, Karoly Mirnics   +5 more
doaj   +1 more source

Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis

mSphere, 2021
Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the ...
Tomye L. Ollinger, Bao Vu, Daniel Murante, Josie E. Parker, Lucia Simonicova, Laura Doorley, Mark A. Stamnes, Steven L. Kelly, P. David Rogers, W. Scott Moye-Rowley, Damian J. Krysan   +10 more
doaj   +1 more source

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

Journal of Lipid Research, 1992
Some bisphosphonates used for the treatment of bone disorders are also potent inhibitors of squalene synthase, a critical enzyme for sterol biosynthesis.
D Amin, SA Cornell, SK Gustafson, SJ Needle, JW Ullrich, GE Bilder, MH Perrone   +6 more
doaj   +1 more source