Antibacterial effect of some eukaryotic sterol biosynthesis inhibitors
Advanced Biomedical Research, 2022 Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in ...
Ghasem Arjmand, Mohammad Reza Haeri
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Post-lanosterol inhibition profile based classification of commonly used prescription medications [PDF]
Translational PsychiatryCholesterol is an essential structural component of all cells, and the sterol biosynthetic pathway provides critical precursors for essential homeostatic molecules. Sterol biosynthesis can be disrupted by pathogenic variants in genes, as well as commonly
Keri A. Tallman +4 more
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Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis
Memorias do Instituto Oswaldo Cruz, 2022 A significant percentage of exogenous cholesterol was found in promastigotes and amastigotes of all studied species of Leishmania, suggesting a biological role for this molecule.
Valter Viana Andrade-Neto +7 more
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Sterol biosynthesis is required for heat resistance but not extracellular survival in leishmania. [PDF]
PLoS Pathogens, 2014 Sterol biosynthesis is a crucial pathway in eukaryotes leading to the production of cholesterol in animals and various C24-alkyl sterols (ergostane-based sterols) in fungi, plants, and trypanosomatid protozoa.
Wei Xu +4 more
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The Oxidosqualene Cyclase from the Oomycete Saprolegnia Parasitica Synthesizes Lanosterol as a Single Product [PDF]
Frontiers in Microbiology, 2016 The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol or cycloartenol. This is catalyzed by an oxidosqualene cyclase.
Paul Dahlin +5 more
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Inhibitors of Sterol Biosynthesis as Staphylococcus aureus Antibiotics [PDF]
Angewandte Chemie International Edition, 2008 One of the truisms in the medicinal chemistry of antibiotics is that there can never be enough scaffolds and structures, whether of natural or synthetic origin. No matter how successful a new antibiotic is upon clinical introduction, the inevitable selection for resistant microbes will limit its useful lifetime.[1] Resistance to all major classes of ...
Christopher T, Walsh +1 more
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Frontiers in Plant Science, 2021 Diosgenin serves as an important precursor of most steroidal drugs in market. Cholesterol was previously deemed as a sterol origin leading to diosgenin biosynthesis.
Liyang Cao +7 more
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Cholesterol metabolism is altered in Rett syndrome: A study on plasma and primary cultured fibroblasts derived from patients [PDF]
, 2014 Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2) are responsible for the onset of the disease.
Di Tunno, Ilenia +6 more
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Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. [PDF]
PLoS Pathogens, 2018 Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans.
Wenxu Zhou +7 more
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Effects of sterol biosynthesis inhibitors on endosymbiont-bearing trypanosomatids [PDF]
FEMS Microbiology Letters, 2006 Some protozoa of the Trypanosomatidae family have a close relationship with an endosymbiotic bacterium. As the prokaryote envelope has a controversial origin, a sterol 24-methyltransferase inhibitor (20-piperidin-2-yl-5alpha-pregnan-3beta,20-diol; 22,26-azasterol) was used as a tool to investigate lipid biosynthetic pathways in Crithidia deanei, an ...
Isabella Vieira, Palmié-Peixoto +5 more
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