Results 21 to 30 of about 16,603 (230)

Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads

Biomolecules
Sterol biosynthesis via the mevalonate-isoprenoid pathway produces ergosterol (24β-methyl cholesta-5,7-dienol) necessary for growth in a wide-range of eukaryotic pathogenic organisms in eukaryotes, including the fungi, trypanosomes and amoebae, while ...
W. David Nes, Minu Chaudhuri, David J. Leaver   +2 more
doaj   +1 more source

Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Journal of Lipid Research, 2019
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT).
Wenxu Zhou, Emilio Ramos, Xunlu Zhu, Paxtyn M. Fisher, Medhanie E. Kidane, Boden H. Vanderloop, Crista D. Thomas, Juqiang Yan, Ujjal Singha, Minu Chaudhuri, Michael T. Nagel, W.David Nes   +11 more
doaj   +1 more source

Basidiomycetes Ganoderma lucidum, Kuehneromyces mutabilis, Flammulina velutipes, Pleurotus ostreatus and Lentinula edodes as Possible Producers of Sterol Biosynthesis Inhibitors

Антибиотики и Химиотерапия
Background. Cardiovascular and infectious diseases, especially those caused by pathogens resistant to existing drugs, remain the most important problem in modern medicine.
A. S. Trenin, E. A. Tsvigun, M. A. Maximova, M. I. Leonteva, A. V. Avtonomova, L. M. Krasnopolskaya   +5 more
doaj   +1 more source

Sterol Metabolism Differentially Contributes to Maintenance and Exit of Quiescence

Frontiers in Cell and Developmental Biology, 2022
Nutrient starvation initiates cell cycle exit and entry into quiescence, a reversible, non-proliferative state characterized by stress tolerance, longevity and large-scale remodeling of subcellular structures.
Carlotta Peselj, Mahsa Ebrahimi, Filomena Broeskamp, Simon Prokisch, Lukas Habernig, Irene Alvarez-Guerra, Verena Kohler, F.-Nora Vögtle, F.-Nora Vögtle, F.-Nora Vögtle, Sabrina Büttner, Sabrina Büttner   +11 more
doaj   +1 more source

Microbial Test-System for Screening of Inhibitors of Sterol Biosynthesis

Антибиотики и Химиотерапия, 2020
New effective economic microbial test-system for screening of microbial metabolites, that are inhibitors of sterol biosynthesis, is proposed. It is based on cultivation of fungal strain Acremonium fusidioides (former Fusidium coccineum), that produces ...
A. S. Trenin
doaj  

Functional analysis of two sterol regulatory element binding proteins in Penicillium digitatum. [PDF]

PLoS ONE, 2017
The sterol regulatory element binding proteins (SREBPs) are key regulators for sterol homeostasis in most fungi. In the citrus postharvest pathogen Penicillium digitatum, the SREBP homolog is required for fungicide resistance and regulation of CYP51 ...
Ruoxin Ruan, Mingshuang Wang, Xin Liu, Xuepeng Sun, Kuang-Ren Chung, Hongye Li   +5 more
doaj   +1 more source

Plant Growth Retardants as Inhibitors of Sterol Biosynthesis in Tobacco Seedlings [PDF]

Plant Physiology, 1974
Three plant-growth retardants 2'-isopropy1-4'-(trimethylammonium chloride)-5-methylphenylpiperidine carboxylate (Amo 1618), beta-chloroethyltrimethylammonium chloride, and tributyl-2, 4-dichlorobenzylphosphonium chloride were tested for their effects on sterol production in, and growth of tobacco (Nicotiana tabacum) seedlings.
T J, Douglas, L G, Paleg
openaire   +2 more sources

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. [PDF]

PLoS Neglected Tropical Diseases, 2015
Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are associated with significant morbidity and mortality, there are few adequate ...
Laura-Isobel McCall, Amale El Aroussi, Jun Yong Choi, Debora F Vieira, Geraldine De Muylder, Jonathan B Johnston, Steven Chen, Danielle Kellar, Jair L Siqueira-Neto, William R Roush, Larissa M Podust, James H McKerrow   +11 more
doaj   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source