Results 11 to 20 of about 16,603 (230)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Inhibitors of Sterol Biosynthesis as Staphylococcus aureus Antibiotics [PDF]

Angewandte Chemie International Edition, 2008
One of the truisms in the medicinal chemistry of antibiotics is that there can never be enough scaffolds and structures, whether of natural or synthetic origin. No matter how successful a new antibiotic is upon clinical introduction, the inevitable selection for resistant microbes will limit its useful lifetime.[1] Resistance to all major classes of ...
Christopher T, Walsh, Michael A, Fischbach   +1 more
openaire   +2 more sources

Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles

Frontiers in Microbiology, 2018
Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis.
Chengcheng Hu, Chengcheng Hu, Mi Zhou, Mi Zhou, Wenzhao Wang, Xianyun Sun, Xianyun Sun, Oded Yarden, Shaojie Li, Shaojie Li   +9 more
doaj   +1 more source

Effects of sterol biosynthesis inhibitors on endosymbiont-bearing trypanosomatids [PDF]

FEMS Microbiology Letters, 2006
Some protozoa of the Trypanosomatidae family have a close relationship with an endosymbiotic bacterium. As the prokaryote envelope has a controversial origin, a sterol 24-methyltransferase inhibitor (20-piperidin-2-yl-5alpha-pregnan-3beta,20-diol; 22,26-azasterol) was used as a tool to investigate lipid biosynthetic pathways in Crithidia deanei, an ...
Isabella Vieira, Palmié-Peixoto, Marcia Rosa, Rocha, Julio A, Urbina, Wanderley, de Souza, Marcelo, Einicker-Lamas, Maria Cristina Machado, Motta   +5 more
openaire   +2 more sources

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

Journal of Lipid Research, 2014
Sterols are an essential class of lipids in eukaryotes, where they serve as structural components of membranes and play important roles as signaling molecules.
Matthias A. Fügi, Kapila Gunasekera, Torsten Ochsenreiter, Xueli Guan, Markus R. Wenk, Pascal Mäser   +5 more
doaj   +1 more source

Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.

Journal of Lipid Research, 1991
Lanosterol 14 alpha-demethylase (P45014DM) is the cytochrome P450 enzyme complex responsible for an early step in cholesterol biosynthesis, namely the 14 alpha-demethylation of lanosterol.
SF Tuck, H Patel, E Safi, CH Robinson
doaj   +1 more source

Isolation and chemical characterization of Δ5,7,24-cholestatrien-3β-ol from pig tissues

Journal of Lipid Research, 1969
Although indirect evidence has implicated Δ5,7,24-cholestatrien-3β-ol a possible intermediate in cholesterol biosynthesis, this sterol has not previously been isolated from tissues. Administration of two inhibitors of cholesterol biosynthesis to pigs led
Terence J. Scallen, W.J. Dean, E.D. Loughran, B.V. Vora   +3 more
doaj   +1 more source

Discovery of inhibitors against SARS-CoV-2 associated fungal coinfections via virtual screening, ADMET evaluation, PASS, molecular docking, dynamics and pharmacophore studies

Arab Journal of Basic and Applied Sciences, 2022
The black fungus is a SARS-CoV-2-associated fungal co-infection. Mechanisms by which antifungal drugs act against Mucormycosis are by inhibition of enzymes implicated in ergosterol biosynthesis or cell wall formation or the drug interaction directly with
Talia Serseg, Khedidja Benarous, Menaouar Serseg, Hafiz Muzzammel Rehman, Youness El Bakri, Souraya Goumri-Said   +5 more
doaj   +1 more source

Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly disease have significant limitations.
Mei Feng, Yiru Jin, Sihyung Yang, Arline M. Joachim, Yu Ning, Luis M. Mori-Quiroz, Jacob Fromm, Chamani Perera, Kai Zhang, Karl A. Werbovetz, Michael Zhuo Wang   +10 more
doaj   +1 more source

Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors

Molecules, 2018
Sterol 14α-demethylase (SDM) is essential for sterol biosynthesis and is the primary molecular target for clinical and agricultural antifungals. SDM has been demonstrated to be a valid drug target for antiprotozoal therapies, and much research has ...
David J. Leaver
doaj   +1 more source