Results 11 to 20 of about 17,106 (263)

Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death.

PLoS ONE, 2013
The protozoan parasite Trypanosoma cruzi displays similarities to fungi in terms of its sterol lipid biosynthesis, as ergosterol and other 24-alkylated sterols are its principal endogenous sterols.
Rafael Luis Kessler, Maurilio José Soares, Christian Macagnan Probst, Marco Aurélio Krieger   +3 more
doaj   +4 more sources

Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors

Molecules, 2018
Sterol 14α-demethylase (SDM) is essential for sterol biosynthesis and is the primary molecular target for clinical and agricultural antifungals. SDM has been demonstrated to be a valid drug target for antiprotozoal therapies, and much research has ...
David J. Leaver
doaj   +2 more sources

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack [PDF]

Journal of Lipid Research, 2014
Sterols are an essential class of lipids in eukaryotes, where they serve as structural components of membranes and play important roles as signaling molecules.
Matthias A. Fügi, Kapila Gunasekera, Torsten Ochsenreiter, Xueli Guan, Markus R. Wenk, Pascal Mäser   +5 more
doaj   +2 more sources

Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles

Frontiers in Microbiology, 2018
Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis.
Chengcheng Hu, Chengcheng Hu, Mi Zhou, Mi Zhou, Wenzhao Wang, Xianyun Sun, Xianyun Sun, Oded Yarden, Shaojie Li, Shaojie Li   +9 more
doaj   +2 more sources

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs [PDF]

Interdisciplinary Perspectives on Infectious Diseases, 2009
Sterols are constituents of the cellular membranes that are essential for their normal structure and function. In mammalian cells, cholesterol is the main sterol found in the various membranes.
Wanderley de Souza, Juliany Cola Fernandes Rodrigues   +1 more
doaj   +2 more sources

Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads

Biomolecules
Sterol biosynthesis via the mevalonate-isoprenoid pathway produces ergosterol (24β-methyl cholesta-5,7-dienol) necessary for growth in a wide-range of eukaryotic pathogenic organisms in eukaryotes, including the fungi, trypanosomes and amoebae, while ...
W. David Nes, Minu Chaudhuri, David J. Leaver   +2 more
doaj   +2 more sources

Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. [PDF]

PLoS Neglected Tropical Diseases, 2015
Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are associated with significant morbidity and mortality, there are few adequate ...
Laura-Isobel McCall, Amale El Aroussi, Jun Yong Choi, Debora F Vieira, Geraldine De Muylder, Jonathan B Johnston, Steven Chen, Danielle Kellar, Jair L Siqueira-Neto, William R Roush, Larissa M Podust, James H McKerrow   +11 more
doaj   +3 more sources

Sterol biosynthesis is required for heat resistance but not extracellular survival in leishmania. [PDF]

PLoS Pathogens, 2014
Sterol biosynthesis is a crucial pathway in eukaryotes leading to the production of cholesterol in animals and various C24-alkyl sterols (ergostane-based sterols) in fungi, plants, and trypanosomatid protozoa.
Wei Xu, Fong-Fu Hsu, Eda Baykal, Juyang Huang, Kai Zhang   +4 more
doaj   +3 more sources

Inhibition of sterol biosynthesis in animal cells by 14 alpha-hydroxymethyl sterols.

Journal of Lipid Research, 1980
The chemical syntheses of a number of 14 alpha-hydroxymethyl sterols and 14 alpha -hydroxymethyl-15 alpha-hydroxysterols and their derivatives have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in animal ...
G J Schroepfer, Jr, E J Parish, R A Pascal, Jr, A A Kandutsch   +3 more
doaj   +2 more sources

Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.

Journal of Lipid Research, 1979
Reported herein are the results of investigations of the effects of a number of 14 alpha-alkyl-substituted 15-oxygenated sterols, prepared by chemical synthesis, on sterol biosynthesis and the levels of 3-hydroxy-3-methylglutaryl CoA reductase activity ...
G J Schroepfer, Jr, E J Parish, M Tsuda, D L Raulston, A A Kandutsch   +4 more
doaj   +2 more sources