Results 11 to 20 of about 32,395 (260)

Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors

Molecules, 2018
Sterol 14α-demethylase (SDM) is essential for sterol biosynthesis and is the primary molecular target for clinical and agricultural antifungals. SDM has been demonstrated to be a valid drug target for antiprotozoal therapies, and much research has ...
David J. Leaver
doaj   +3 more sources

Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death.

PLoS ONE, 2013
The protozoan parasite Trypanosoma cruzi displays similarities to fungi in terms of its sterol lipid biosynthesis, as ergosterol and other 24-alkylated sterols are its principal endogenous sterols.
Rafael Luis Kessler, Maurilio José Soares, Christian Macagnan Probst, Marco Aurélio Krieger   +3 more
doaj   +3 more sources

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. [PDF]

, 2017
BackgroundChagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variable ...
Calvet, Claudia Magalhaes, Choi, Jun Yong, de Mesquita, Liliane Batista, de Souza Pereira, Mirian Claudia, Hirata, Ken, Lostracco-Johnson, Sharon, McKerrow, James H, Meuser-Batista, Marcelo, Nogueira, Alanderson, Podust, Larissa M, Roush, William R, Silva, Tatiana Araujo, Siqueira-Neto, Jair Lage, Suzuki, Brian, Thomas, Diane   +14 more
core   +7 more sources

Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis

Biomolecules, 2023
The concurrent use of several medications is a common practice in the treatment of complex psychiatric conditions. One such commonly used combination is aripiprazole (ARI), an antipsychotic, and trazodone (TRZ), an antidepressant.
Zeljka Korade, Allison Anderson, Marta Balog, Keri A. Tallman, Ned A. Porter, Karoly Mirnics   +5 more
doaj   +1 more source

Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis

mSphere, 2021
Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the ...
Tomye L. Ollinger, Bao Vu, Daniel Murante, Josie E. Parker, Lucia Simonicova, Laura Doorley, Mark A. Stamnes, Steven L. Kelly, P. David Rogers, W. Scott Moye-Rowley, Damian J. Krysan   +10 more
doaj   +1 more source

Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

Microorganisms, 2022
The sterol biosynthesis pathway of Leishmania spp. is used as a pharmacological target; however, available information about the mechanisms of the regulation and remodeling of sterol-related genes is scarce.
Thais Tenorio Soares Fujii, Pollyanna Stephanie Gomes, Rubens Lima do Monte-Neto, Daniel Claudio de Oliveira Gomes, Marc Ouellette, Eduardo Caio Torres-Santos, Valter Viana Andrade-Neto, Herbert Leonel de Matos Guedes   +7 more
doaj   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

Journal of Lipid Research, 1992
Some bisphosphonates used for the treatment of bone disorders are also potent inhibitors of squalene synthase, a critical enzyme for sterol biosynthesis.
D Amin, SA Cornell, SK Gustafson, SJ Needle, JW Ullrich, GE Bilder, MH Perrone   +6 more
doaj   +1 more source

Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles

Frontiers in Microbiology, 2018
Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis.
Chengcheng Hu, Chengcheng Hu, Mi Zhou, Mi Zhou, Wenzhao Wang, Xianyun Sun, Xianyun Sun, Oded Yarden, Shaojie Li, Shaojie Li   +9 more
doaj   +1 more source

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

Journal of Lipid Research, 2014
Sterols are an essential class of lipids in eukaryotes, where they serve as structural components of membranes and play important roles as signaling molecules.
Matthias A. Fügi, Kapila Gunasekera, Torsten Ochsenreiter, Xueli Guan, Markus R. Wenk, Pascal Mäser   +5 more
doaj   +1 more source