Results 21 to 30 of about 23,950 (217)

Urinary clearance and metabolism of mevalonate by the isolataed perfused rat kidney.

Journal of Lipid Research, 1981
The urinary excretion and the incorporation into lipids of R[3-14C]mevalonate was investigated in isolated rat kidneys perfused with physiological concentration sof the substrate (80-500 pmol/ml).
H Brunengraber, S B Weinstock, D L Story, R R Kopito   +3 more
doaj   +1 more source

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Frontiers in Oncology, 2021
A hallmark of cancer cells includes a metabolic reprograming that provides energy, the essential building blocks, and signaling required to maintain survival, rapid growth, metastasis, and drug resistance of many cancers.
Borja Guerra, Carlota Recio, Haidée Aranda-Tavío, Miguel Guerra-Rodríguez, José M. García-Castellano, Leandro Fernández-Pérez   +5 more
doaj   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy

Frontiers in Oncology, 2020
Recently, targeting metabolic reprogramming has emerged as a potential therapeutic approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic helix-loop-helix leucine zipper transcription factor, mainly regulates genes ...
Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Qingxia Huang, Daqing Zhao, Boyang Jason Wu, Xiangyan Li   +8 more
doaj   +1 more source

Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man1

Journal of Lipid Research, 1977
The purpose of the study was to develop a kinetic method for measurement of different parameters of cholesterol metabolism in man using labeled cholesterol precursors that could initially be incorporated even into the slowly exchangeable cholesterol pool.
M Kekki, T A Miettinen, B Wahlström
doaj   +1 more source

Immunomodulatory effects of atorvastatin on peripheral blood mononuclear cells infected with Mycobacterium tuberculosis

Frontiers in Immunology
BackgroundTuberculosis (TB) remains a major global health threat, contributing substantially to high morbidity and mortality rates. This underscores the urgent need for more effective interventions. Recent studies highlight the potential of host-directed
Solima Sabeel, Solima Sabeel, Solima Sabeel, Bongani Motaung, Bongani Motaung, Mumin Ozturk, Mumin Ozturk, Trevor S. Mafu, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Friedrich Thienemann, Friedrich Thienemann, Friedrich Thienemann, Reto Guler, Reto Guler, Reto Guler   +16 more
doaj   +1 more source

Biosynthesis of Δ7-cholesten-3Β-ol, Δ5,7-cholestadien-3Β-ol, and Δ5-cholesten-3Β-ol by guinea pig intestinal mucosa in vitro

Journal of Lipid Research, 1966
Methods were developed for the separation and determination of the various 27-carbon sterols of intestinal mucosa by means of thin-layer chromatography.
Robert K. Ockner, Leonard Laster
doaj   +1 more source

(R)-Mevalonate 3-Phosphate Is an Intermediate of the Mevalonate Pathway in Thermoplasma acidophilum [PDF]

Journal of Biological Chemistry, 2014
The lack of a few conserved enzymes in the classical mevalonate pathway and the widespread existence of isopentenyl phosphate kinase suggest the presence of a partly modified mevalonate pathway in most archaea and in some bacteria. In the pathway, (R)-mevalonate 5-phosphate is thought to be metabolized to isopentenyl diphosphate via isopentenyl ...
Yasuhiro, Azami, Ai, Hattori, Hiroto, Nishimura, Hiroshi, Kawaide, Tohru, Yoshimura, Hisashi, Hemmi   +5 more
openaire   +2 more sources

Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome [PDF]

Orphanet Journal of Rare Diseases, 2006
Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis. At least 30 patients with MVA and 180 patients with HIDS have been reported worldwide.
Hoffmann Georg F, Haas Dorothea
openaire   +3 more sources

Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells

Journal of Lipid Research, 2003
Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (42) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans.
Rosa A. Canuto, Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Riccardo Autelli, Paola Costelli, Gabriella Bonelli, Francesco M. Baccino   +8 more
doaj   +1 more source