Results 21 to 30 of about 24,078 (213)

Determination of mevalonate in blood plasma in man and rat. Mevalonate “tolerance” tests in man.

Journal of Lipid Research, 1979
A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation of ...
G Popják, G Boehm, T S Parker, J Edmond, P A Edwards, A M Fogelman   +5 more
doaj   +1 more source

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Frontiers in Oncology, 2021
A hallmark of cancer cells includes a metabolic reprograming that provides energy, the essential building blocks, and signaling required to maintain survival, rapid growth, metastasis, and drug resistance of many cancers.
Borja Guerra, Carlota Recio, Haidée Aranda-Tavío, Miguel Guerra-Rodríguez, José M. García-Castellano, Leandro Fernández-Pérez   +5 more
doaj   +1 more source

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy

Frontiers in Oncology, 2020
Recently, targeting metabolic reprogramming has emerged as a potential therapeutic approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic helix-loop-helix leucine zipper transcription factor, mainly regulates genes ...
Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Qingxia Huang, Daqing Zhao, Boyang Jason Wu, Xiangyan Li   +8 more
doaj   +1 more source

Measurement of cholesterol synthesis in kinetically defined pools using fecal steroid analysis and double labeling technique in man1

Journal of Lipid Research, 1977
The purpose of the study was to develop a kinetic method for measurement of different parameters of cholesterol metabolism in man using labeled cholesterol precursors that could initially be incorporated even into the slowly exchangeable cholesterol pool.
M Kekki, T A Miettinen, B Wahlström
doaj   +1 more source

Immunomodulatory effects of atorvastatin on peripheral blood mononuclear cells infected with Mycobacterium tuberculosis

Frontiers in Immunology
BackgroundTuberculosis (TB) remains a major global health threat, contributing substantially to high morbidity and mortality rates. This underscores the urgent need for more effective interventions. Recent studies highlight the potential of host-directed
Solima Sabeel, Solima Sabeel, Solima Sabeel, Bongani Motaung, Bongani Motaung, Mumin Ozturk, Mumin Ozturk, Trevor S. Mafu, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Friedrich Thienemann, Friedrich Thienemann, Friedrich Thienemann, Reto Guler, Reto Guler, Reto Guler   +16 more
doaj   +1 more source

Activation of the plant mevalonate pathway by extracellular ATP

Nature Communications, 2022
Products of the mevalonate pathway support plant development. Here the authors show that the extracellular ATP receptor P2K1 phosphorylates mevalonate kinase and this affects the mevalonate pathway.
Sung-Hwan Cho, Katalin Tóth, Daewon Kim, Phuc H. Vo, Chung-Ho Lin, Pubudu P. Handakumbura, Albert Rivas Ubach, Sterling Evans, Ljiljana Paša-Tolić, Gary Stacey   +9 more
doaj   +1 more source

Biosynthesis of Δ7-cholesten-3Β-ol, Δ5,7-cholestadien-3Β-ol, and Δ5-cholesten-3Β-ol by guinea pig intestinal mucosa in vitro

Journal of Lipid Research, 1966
Methods were developed for the separation and determination of the various 27-carbon sterols of intestinal mucosa by means of thin-layer chromatography.
Robert K. Ockner, Leonard Laster
doaj   +1 more source

(R)-Mevalonate 3-Phosphate Is an Intermediate of the Mevalonate Pathway in Thermoplasma acidophilum [PDF]

Journal of Biological Chemistry, 2014
The lack of a few conserved enzymes in the classical mevalonate pathway and the widespread existence of isopentenyl phosphate kinase suggest the presence of a partly modified mevalonate pathway in most archaea and in some bacteria. In the pathway, (R)-mevalonate 5-phosphate is thought to be metabolized to isopentenyl diphosphate via isopentenyl ...
Yasuhiro, Azami, Ai, Hattori, Hiroto, Nishimura, Hiroshi, Kawaide, Tohru, Yoshimura, Hisashi, Hemmi   +5 more
openaire   +2 more sources

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells

Journal of Lipid Research, 2003
Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (42) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans.
Rosa A. Canuto, Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Riccardo Autelli, Paola Costelli, Gabriella Bonelli, Francesco M. Baccino   +8 more
doaj   +1 more source