Results 21 to 30 of about 30,985 (250)

Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins

Frontiers in Pharmacology, 2020
Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening bronchoconstriction.
Robin A. Lu, Amir A. Zeki, Sumati Ram-Mohan, Nhan Nguyen, Yan Bai, Kenneth Chmiel, Stevan Pecic, Xingbin Ai, Ramaswamy Krishnan, Chandra C. Ghosh   +9 more
doaj   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Glucose restriction drives spatial reorganization of mevalonate metabolism

eLife, 2021
Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood.
Sean Rogers, Hanaa Hariri, N Ezgi Wood, Natalie Ortiz Speer, W Mike Henne   +4 more
doaj   +1 more source

Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis

Frontiers in Pharmacology, 2022
Background and aim: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, with most patients succumbing rapidly after diagnosis.
Lloyd Tanner, Jesper Bergwik, Andrew B. Single, Ravi K. V. Bhongir, Jonas S. Erjefält, Arne Egesten   +5 more
doaj   +1 more source

Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity

, 2022
Mitochondrial dysfunction induces a strong adaptive retrograde signaling response; however, many of the downstream effectors of this response remain to be discovered.
Descombes, Patrick, Wiederkehr, Andreas, Lefebvre, Gregory, Santo-Domingo, Jaime, Metairon, Sylviane, Wall, Christopher Tadhg James   +5 more
core   +1 more source

c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway

Biomedicines, 2022
It has been shown that wild-type (wt)p53 inhibits oncogene c-Myc while mutant (mut)p53 may transactivate it, with an opposite behavior that frequently occurs in the crosstalk of wt or mutp53 with molecules/pathways promoting carcinogenesis.
Maria Anele Romeo, Maria Saveria Gilardini Montani, Andrea Arena, Rossella Benedetti, Gabriella D’Orazi, Mara Cirone   +5 more
doaj   +1 more source

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase [PDF]

, 2007
This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the ...
Tanja Sgraja, Smith, Terry K, Terry K Smith, Sgraja, Tanja, Hunter, William N., William N Hunter, Hunter, William N   +6 more
core   +1 more source

Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL

Journal of Lipid Research, 2003
Retention of LDL in the artery intima is mediated by extracellular matrix proteoglycans and plays an important role in the initiation of atherosclerosis.
C. Daniel Meyers, Lisa R. Tannock, Thomas N. Wight, Alan Chait   +3 more
doaj   +1 more source

Mevalonate Biosynthesis in Plants

Critical Reviews in Biochemistry and Molecular Biology, 1999
(1999). Mevalonate Biosynthesis in Plants. Critical Reviews in Biochemistry and Molecular Biology: Vol. 34, No. 2, pp. 107-122.
Bach, Thomas J., Boronat i Margosa, Albert, Campos Martínez, Narciso, Ferrer i Prats, Albert, Vollack, Kai-Uwe   +4 more
openaire   +4 more sources

Influx of cholesterol into plasma in rabbits with fasting hyperbetalipoproteinemia

Journal of Lipid Research, 1974
New Zealand white rabbits exhibited as much as a threefold increase in plasma cholesterol but no change in hepatic cholesterol when fasted for 7–9 days.
H.C. Klauda, D.B. Zilversmit
doaj   +1 more source