Results 41 to 50 of about 30,985 (250)
Journal of Lipid Research, 1977 The purpose of the study was to develop a kinetic method for measurement of different parameters of cholesterol metabolism in man using labeled cholesterol precursors that could initially be incorporated even into the slowly exchangeable cholesterol pool.
M Kekki, T A Miettinen, B Wahlström
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Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy
Frontiers in Oncology, 2020 Recently, targeting metabolic reprogramming has emerged as a potential therapeutic approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic helix-loop-helix leucine zipper transcription factor, mainly regulates genes ...
Linyuan Xue +8 more
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Mevalonate Dependence and Apoptosis in Blood Cancers
, 2021 There is a resurgence of interest in understanding the role of the mevalonate pathway in cancer. The on-target anti-cancer effects of the clinical mevalonate inhibitors, statins, are plentiful and diverse across several cancer models.
Juarez, Dennis
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Frontiers in ImmunologyBackgroundTuberculosis (TB) remains a major global health threat, contributing substantially to high morbidity and mortality rates. This underscores the urgent need for more effective interventions. Recent studies highlight the potential of host-directed
Solima Sabeel +16 more
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p53 regulates Mevalonate Metabolic pathway
, 2014 2012-2013The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced expression of mevalonate
D'Alessandro, Alba
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A cofactor-promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis. [PDF]
Protein SciAbstract The Lyme disease pathogen Borrelia burgdorferi contains a highly reduced genome lacking many primary metabolic pathways. However, B. burgdorferi retains the mevalonate pathway that synthesizes isopentenyl pyrophosphate (IPP), the precursor to the peptidoglycan carrier lipid.
Paddy IA +7 more
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Journal of Lipid Research, 1966 Methods were developed for the separation and determination of the various 27-carbon sterols of intestinal mucosa by means of thin-layer chromatography.
Robert K. Ockner, Leonard Laster
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Activation of the plant mevalonate pathway by extracellular ATP
Nature Communications, 2022 Products of the mevalonate pathway support plant development. Here the authors show that the extracellular ATP receptor P2K1 phosphorylates mevalonate kinase and this affects the mevalonate pathway.
Sung-Hwan Cho +9 more
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(R)-Mevalonate 3-Phosphate Is an Intermediate of the Mevalonate Pathway in Thermoplasma acidophilum [PDF]
Journal of Biological Chemistry, 2014 The lack of a few conserved enzymes in the classical mevalonate pathway and the widespread existence of isopentenyl phosphate kinase suggest the presence of a partly modified mevalonate pathway in most archaea and in some bacteria. In the pathway, (R)-mevalonate 5-phosphate is thought to be metabolized to isopentenyl diphosphate via isopentenyl ...
Yasuhiro, Azami +5 more
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Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome [PDF]
Orphanet Journal of Rare Diseases, 2006 Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis. At least 30 patients with MVA and 180 patients with HIDS have been reported worldwide.
Hoffmann Georg F, Haas Dorothea
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