Results 51 to 60 of about 24,078 (213)

Comprehensive elucidation of volatile, phenolic, and organic acid profiles in Turkish mallow (Malva sylvestris L.) petal herbal tea: impact of diverse brewing conditions

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Mallow (Malva sylvestris L.) petals are traditionally consumed as herbal tea across the Mediterranean for their soothing and anti‐inflammatory properties; however, scientific characterization of this consumption‐relevant matrix under realistic brewing conditions remains scarce.
Armin Amanpour, Ali Tekin, Ali Adnan Hayaloglu   +2 more
wiley   +1 more source

Microbial Test-System for Screening of Inhibitors of Sterol Biosynthesis

Антибиотики и Химиотерапия, 2020
New effective economic microbial test-system for screening of microbial metabolites, that are inhibitors of sterol biosynthesis, is proposed. It is based on cultivation of fungal strain Acremonium fusidioides (former Fusidium coccineum), that produces ...
A. S. Trenin
doaj  

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. [PDF]

PLoS ONE, 2014
HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate that ...
Parmida Ranji, Manish Rauthan, Christophe Pitot, Marc Pilon   +3 more
doaj   +1 more source

Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease

VIEW, EarlyView.
This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin, Lijie Ma, Yuqing Yuan, Kaiyi Zhu, Zhaohui Tong, Qianmei Sun   +5 more
wiley   +1 more source

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

Insect Science, EarlyView.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji, Qing Xie, Xiaoxiao Chang, Juan Shi   +3 more
wiley   +1 more source

The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats.

Journal of Lipid Research, 1981
Circulating mevalonate is metabolized by two mechanisms: the sterol pathways leading to cholesterol and the shunt pathway resulting in CO2 production. The kidney is the chief site of circulating mevalonate metabolism by both pathways.
K R Feingold, M H Wiley, G MacRae, M D Siperstein   +3 more
doaj   +1 more source

LsFAMeT and LsJHAMT coordinate JH biosynthesis to regulate fecundity in Laodelphax striatellus

Insect Science, EarlyView.
The small brown planthopper (SBPH), Laodelphax striatellus, can trigger large‐scale outbreaks when encountering suitable habitats during migration due to their strong reproductive ability. This study investigated the role of juvenile hormone (JH) in regulating SBPH reproduction.
Yan Guo, Bing‐Bing Shi, Xue‐Qi Zhang, Qiong Yang   +3 more
wiley   +1 more source

Urinary Metabolites of Mevalonic Acid: Evidence That Mevalonic Acid is not a Precursor of Isovalthine

Experimental Biology and Medicine, 1961
SummarySynthetic isovalthine (S-(isopropyl-carboxymethyl)-cysteine) was added to urine from hypercholesterolemic patients that had received mevalonic acid-2-C14 intravenously. Isovalthine recovered from the urine was found to be devoid of radioactivity thus indicating that either (a) mevalonic acid is not a precursor of isovalthine, or (b) mevalonic ...
L D, WRIGHT, W P, HOLLANDER
openaire   +2 more sources

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source