Results 41 to 50 of about 38,617 (240)

NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

iScience, 2021
Summary: Lipids, such as cholesterol and fatty acids, influence cell signaling, energy storage, and membrane formation. Cholesterol is biosynthesized through the mevalonate pathway, and aberrant metabolism causes metabolic diseases.
Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi   +10 more
doaj   +1 more source

A comparative study of Gaussian Graphical Model approaches for genomic data [PDF]

, 2011
The inference of networks of dependencies by Gaussian Graphical models on high-throughput data is an open issue in modern molecular biology. In this paper we provide a comparative study of three methods to obtain small sample and high dimension estimates
Ancona, N., Anglani, R., Creanza, T. M., Liuzzi, V. C., Mukherjee, S., Stifanelli, P. F.   +5 more
core   +2 more sources

Different adaptation strategies of two citrus scion/rootstock combinations in response to drought stress [PDF]

, 2017
Scion/rootstock interaction is important for plant development and for breeding programs. In this context, polyploid rootstocks presented several advantages, mainly in relation to biotic and abiotic stresses.
Bonatto, Diego, Coelho Filho, Mauricio Antonio, Da Silva Gesteira, Abelmon, De Andrade Silva, Edson Mario, de Souza, Joadson Dutra, Micheli, Fabienne, Morillon, Raphaël   +6 more
core   +8 more sources

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging [PDF]

, 2014
Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is the mevalonate pathway.
Bardenheier, Annabelle, Bening-Abu-Schach, Ulrike, Boxem, Mike, Broday, Limor, Ching, Kaitlin, Chou, Tsui-Fen, Koorman, Thijs, Mishra, Prashant, Podolsky, Lisa, Sapir, Amir, Sternberg, Paul W., Tsur, Assaf   +11 more
core   +3 more sources

Targeting prenylation inhibition through the mevalonate pathway

RSC Medicinal Chemistry, 2020
Recent progress on mevalonate pathway inhibitor development.
Pimyupa Manaswiyoungkul, Elvin D. de Araujo, Patrick T. Gunning   +2 more
openaire   +3 more sources

Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo

Journal of Ovarian Research, 2023
High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the fallopian tube epithelium.
Madison Pereira, Alice Glogova, Jacob Haagsma, Julia Stewart, Trevor G. Shepherd, Jim Petrik   +5 more
doaj   +1 more source

Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin [PDF]

, 2017
Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens.
A Baxter, A Bellier, A Das, AE Christian, AF Read, B Page, BH Jost, BN Bonnett, CY Kao, DL Huffman, DO Ballard, DS Schneider, EP Kilsdonk, G Krikun, G Preta, GD Healey, IM Sheldon, IM Sheldon, JD Bergstrom, JG Cronin, JL Goldstein, JL Goldstein, JM Park, JW Rosch, K Bloch, KS Giddings, L Gurcel, L Pokrajac, L Raberg, LJ Bischof, LJ Sharpe, MD Peraro, MJ Rogers, ML Turner, MLS Bicalho, MR Amos, MR Gonzalez, R Medzhitov, RK Tweten, S Statt, S Westermann, SA Bustin, SJ Billington, SJ Billington, SJ Billington, T Mosmann, Y Lange   +46 more
core   +2 more sources

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

Cell Reports, 2019
Summary: The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive.
Maheshwor Timilshina, Zhiwei You, Sonja M. Lacher, Suman Acharya, Liyuan Jiang, Youra Kang, Jung-Ae Kim, Hyeun Wook Chang, Keuk-Jun Kim, Byoungduck Park, Jae-Hyoung Song, Hyun-Jeong Ko, Yun-Yong Park, Min-Jung Ma, Mahesh Raj Nepal, Tae Cheon Jeong, Yeonseok Chung, Ari Waisman, Jae-Hoon Chang   +18 more
doaj   +1 more source

Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase

Nature Communications, 2020
Mevalonate diphosphate decarboxylase (MDD) is a key enzyme in the mevalonate pathway and catalyses the decarboxylation of mevalonate-5-diphosphate to isopentenyl diphosphate.
Chun-Liang Chen, Lake N. Paul, James C. Mermoud, Calvin Nicklaus Steussy, Cynthia V. Stauffacher   +4 more
doaj   +1 more source

Mutant-based model of two independent pathways for carotenoid-mediated chloroplast biogenesis in Arabidopsis embryos [PDF]

, 2019
Chloroplasts are essential for autonomous plant growth, and their biogenesis is a complex process requiring both plastid and nuclear genome. One of the essential factors required for chloroplast biogenesis are carotenoids.
Colinas Martinez, Maite, Kopcsayová, Diana, Košuth, Ján, Vranová, Eva   +3 more
core   +1 more source