Results 51 to 60 of about 38,617 (240)

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]

, 2011
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong, Durrant, Jacob D, Gorfe, Alemayehu A, Li, Jikun, McCammon, J Andrew, Oldfield, Eric, Sankovsky, Anna, Zhu, Wei   +7 more
core   +5 more sources

Applying asymptotic methods to synthetic biology: modelling the reaction kinetics of the mevalonate pathway [PDF]

, 2016
The mevalonate pathway is normally found in eukaryotes, and allows for the production of isoprenoids, a useful class of organic compounds. This pathway has been successfully introduced to Escherichia coli, enabling a biosynthetic production route for ...
Dalwadi, Mohit P., Garavaglia, Marco, King, John R., Minton, Nigel P., Webb, Joseph P.   +4 more
core   +4 more sources

Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells. [PDF]

PLoS ONE, 2013
Durable tumor cell eradication by chemotherapy is challenged by the development of multidrug-resistance (MDR) and the failure to induce immunogenic cell death.
Chiara Riganti, Barbara Castella, Joanna Kopecka, Ivana Campia, Marta Coscia, Gianpiero Pescarmona, Amalia Bosia, Dario Ghigo, Massimo Massaia   +8 more
doaj   +1 more source

Inhibition of the mevalonate pathway improves myocardial fibrosis

Experimental and Therapeutic Medicine, 2021
The mevalonate (MVA) pathway serves an important role in ventricular remodeling. Targeting the MVA pathway has protective effects against myocardial fibrosis. The present study aimed to investigate the mechanism behind these effects. Primary cultured cardiac fibroblasts from C57BL/6 mice were treated in vitro in 5 groups: i) negative control; ii ...
Xu, Huifeng, Shen, Yi, Liang, Chenyu, Wang, Haifeng, Huang, Junling, Xue, Pengcheng, Luo, Ming   +6 more
openaire   +3 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus

Nature Communications, 2018
Oncolytic viruses selectively kill tumour cells and induce anti-tumour immunity. Here, the AUs demonstrate the anti-viral effect of the mevalonate pathway on oncolytic virus M1 in refractory cancer cells and provide evidence for a combination strategy of
Jiankai Liang, Li Guo, Kai Li, Xiao Xiao, Wenbo Zhu, Xiaoke Zheng, Jun Hu, Haipeng Zhang, Jing Cai, Yaya Yu, Yaqian Tan, Chuntao Li, Xincheng Liu, Cheng Hu, Ying Liu, Pengxin Qiu, Xingwen Su, Songmin He, Yuan Lin, Guangmei Yan   +19 more
doaj   +1 more source

Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy

Cell Reports, 2015
Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance.
Teemu P. Miettinen, Mikael Björklund
doaj   +1 more source

NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer

Cell Reports, 2023
Summary: Dysregulation of transcription is a hallmark of cancer, including bladder cancer (BLCA). CRISPR-Cas9 screening using a lentivirus library with single guide RNAs (sgRNAs) targeting human transcription factors and chromatin modifiers is used to ...
Zefu Liu, Xianchong Zheng, Jiawei Chen, Lisi Zheng, Zikun Ma, Lei Chen, Minhua Deng, Huancheng Tang, Liwen Zhou, Tiebang Kang, Yuanzhong Wu, Zhuowei Liu   +11 more
doaj   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source