Results 21 to 30 of about 38,617 (240)

Dysregulation of the mevalonate pathway promotes transformation [PDF]

Proceedings of the National Academy of Sciences, 2010
The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding of how metabolism contributes to tumorigenesis, we will be better able to integrate the targeting of these fundamental biochemical pathways into
James W, Clendening, Aleks, Pandyra, Paul C, Boutros, Samah, El Ghamrasni, Fereshteh, Khosravi, Grace A, Trentin, Anna, Martirosyan, Anne, Hakem, Razqallah, Hakem, Igor, Jurisica, Linda Z, Penn   +10 more
openaire   +2 more sources

A synthetic biochemistry platform for cell free production of monoterpenes from glucose. [PDF]

, 2017
Cell-free systems designed to perform complex chemical conversions of biomass to biofuels or commodity chemicals are emerging as promising alternatives to the metabolic engineering of living cells.
Bowie, James U, Korman, Tyler P, Opgenorth, Paul H   +2 more
core   +2 more sources

Mevalonate Metabolism in Immuno-Oncology

Frontiers in Immunology, 2017
Immuno-oncology not only refers to the multifaceted relationship between our immune system and a developing cancer but also includes therapeutic approaches that harness the body’s immune system to fight cancer.
Georg Gruenbacher, Martin Thurnher
doaj   +1 more source

An enzymatic platform for the synthesis of isoprenoid precursors. [PDF]

PLoS ONE, 2014
The isoprenoid family of compounds is estimated to contain ∼ 65,000 unique structures including medicines, fragrances, and biofuels. Due to their structural complexity, many isoprenoids can only be obtained by extraction from natural sources, an ...
Sofia B Rodriguez, Thomas S Leyh
doaj   +1 more source

Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]

, 2015
Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut, A Hilgendorff, AA Ajibade, BI Gavrila, BP Leung, C Arnaud, C Guiducci, C Guijarro, E Munro, EH Choy, FL Zhang, FM Brennan, FM Brennan, FX Zhang, G Falgarone, H Kanda, H Kanda, H Lin, H Methe, H Okamoto, H Radner, H Wesche, H Xu, I Zelvyte, J Qin, Jason Ferdjani, K Chaabo, KA Fitzgerald, KA Fitzgerald, KH Costenbader, KI Paraskevas, L Liu, LA O’Neill, Lisa Mullen, LM Mullen, M Khoury, M Ortego, M Yamamoto, M Yoshida, MA Gonzalez-Gay, QQ Huang, S Alzabin, S Doornum Van, Sandra Sacre, SL Chinault, SM Sacre, T Mosmann, TT Tang, U Schonbeck   +48 more
core   +1 more source

HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways [PDF]

Cancers, 2019
Heat shock factor 1 (HSF1) is an essential transcription factor in cellular adaptation to various stresses such as heat, proteotoxic stress, metabolic stress, reactive oxygen species, and heavy metals. HSF1 promotes cancer development and progression, and increased HSF1 levels are frequently observed in multiple types of cancers.
Kang, Hyeji, Oh, Taerim, Bahk, Young Yil, Kim, Geon-Hee, Kan, Sang-Yeon, Shin, Dong Hoon, Kim, Ji Hyung, Lim, Ji-Hong   +7 more
openaire   +2 more sources

GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway [PDF]

, 2016
Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules produced by solanaceous species. They contribute to pathogen defence but are toxic to humans and considered as anti-nutritional compounds.
Aharoni, Asaph, Burdman, Saul, Cárdenas, Pablo D, Dewangan, Veena, Giri, Ashok P, Goossens, Alain, Malitsky, Sergey, Meir, Sagit, Pollier, Jacob, Rogachev, Ilana, Sonawane, Prashant D, Tal, Lior, Vanden Bossche, Robin, Weithorn, Efrat   +13 more
core   +1 more source

Mevalonate Pathway Promiscuity Enables Noncanonical Terpene Production [PDF]

ACS Synthetic Biology, 2019
Lepidoptera (butterflies and moths) make the six-carbon compounds homoisopentenyl pyrophosphate (HIPP) and homodimethylallyl pyrophosphate (HDMAPP) that are incorporated into 16, 17, and 18 carbon farnesyl pyrophosphate (FPP) analogues. In this work we heterologously expressed the lepidopteran modified mevalonate pathway, a propionyl-CoA ligase, and ...
Christopher B. Eiben, Tristan de Rond, Clayton Bloszies, Jennifer Gin, Jennifer Chiniquy, Edward E. K. Baidoo, Christopher J. Petzold, Nathan J. Hillson, Oliver Fiehn, Jay D. Keasling   +9 more
openaire   +5 more sources

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]

, 2019
We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua, Eibl, Guido, Hao, Fang, Rozengurt, Enrique, Sinnett-Smith, James, Wang, Jing, Xu, Qinhong, Yu, Shuo   +7 more
core   +2 more sources

The Mevalonate Pathway ofStaphylococcus aureus [PDF]

Journal of Bacteriology, 2009
ABSTRACTIsoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophosphate is absolutely required for the formation of
Carl J, Balibar, Xiaoyu, Shen, Jianshi, Tao   +2 more
openaire   +2 more sources