Results 21 to 30 of about 21,930 (203)

Evidence for an underestimation of the shunt pathway of mevalonate metabolism in slices of livers and kidneys from fasted rats and rats in diabetic ketosis

Journal of Lipid Research, 1982
Yields of (14)CO(2) from [2-(14)C]mevalonate and [5-(14)C]mevalonate have been used by others to estimate the activity of the non-sterol-forming pathway, also called the mevalonate shunt pathway, and yields of (14)C in sterols have been used to estimate ...
P S Brady, W C Schumann, S Ohgaku, R F Scofield, B R Landau   +4 more
doaj   +1 more source

MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway

Scientific Reports, 2022
The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer.
Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita, Naohiko Seki, Bahityar Rahmutulla, Atsushi Kaneda, Siti Nurul Zhahara, Yingbo Gong, Motoi Nishimura, Shoichiro Kawauchi, Eiryo Kawakami, Tomoaki Tanaka   +18 more
doaj   +1 more source

Mevalonate Metabolism in Immuno-Oncology

Frontiers in Immunology, 2017
Immuno-oncology not only refers to the multifaceted relationship between our immune system and a developing cancer but also includes therapeutic approaches that harness the body’s immune system to fight cancer.
Georg Gruenbacher, Martin Thurnher
doaj   +1 more source

An enzymatic platform for the synthesis of isoprenoid precursors. [PDF]

PLoS ONE, 2014
The isoprenoid family of compounds is estimated to contain ∼ 65,000 unique structures including medicines, fragrances, and biofuels. Due to their structural complexity, many isoprenoids can only be obtained by extraction from natural sources, an ...
Sofia B Rodriguez, Thomas S Leyh
doaj   +1 more source

Deficiency and absence of endogenous isoprene in adults, disqualified its putative origin

Heliyon, 2021
Background: Isoprene (C5H8) is a clinically important breath metabolite. Although, hundreds of studies have reported differential expressions in isoprene exhalation as breath biomarker for diverse diseases, the substance couldn't enter to clinical ...
Pritam Sukul, Anna Richter, Jochen K. Schubert, Wolfram Miekisch   +3 more
doaj   +1 more source

Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer

Molecular Oncology, 2019
Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors (statins) may overcome resistance.
Natalia Ricco, Amy Flor, Don Wolfgeher, Elena V. Efimova, Aishwarya Ramamurthy, Oliver K. Appelbe, Jacqueline Brinkman, Andrew W. Truman, Michael T. Spiotto, Stephen J. Kron   +9 more
doaj   +1 more source

The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats.

Journal of Lipid Research, 1981
Circulating mevalonate is metabolized by two mechanisms: the sterol pathways leading to cholesterol and the shunt pathway resulting in CO2 production. The kidney is the chief site of circulating mevalonate metabolism by both pathways.
K R Feingold, M H Wiley, G MacRae, M D Siperstein   +3 more
doaj   +1 more source

Further engineering of R. toruloides for the production of terpenes from lignocellulosic biomass

Biotechnology for Biofuels, 2021
Background Mitigation of climate change requires that new routes for the production of fuels and chemicals be as oil-independent as possible. The microbial conversion of lignocellulosic feedstocks into terpene-based biofuels and bioproducts represents ...
James Kirby, Gina M. Geiselman, Junko Yaegashi, Joonhoon Kim, Xun Zhuang, Mary Bao Tran-Gyamfi, Jan-Philip Prahl, Eric R. Sundstrom, Yuqian Gao, Nathalie Munoz, Kristin E. Burnum-Johnson, Veronica T. Benites, Edward E. K. Baidoo, Anna Fuhrmann, Katharina Seibel, Bobbie-Jo M. Webb-Robertson, Jeremy Zucker, Carrie D. Nicora, Deepti Tanjore, Jon K. Magnuson, Jeffrey M. Skerker, John M. Gladden   +21 more
doaj   +1 more source

NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

iScience, 2021
Summary: Lipids, such as cholesterol and fatty acids, influence cell signaling, energy storage, and membrane formation. Cholesterol is biosynthesized through the mevalonate pathway, and aberrant metabolism causes metabolic diseases.
Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi   +10 more
doaj   +1 more source

Mevalonate metabolism governs cancer immune surveillance

OncoImmunology, 2017
The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs ...
Georg Gruenbacher, Martin Thurnher
doaj   +1 more source