Results 171 to 180 of about 209,419 (263)

Factors influencing PrEP adoption in sexual health clinics within Ontario's public health system: a qualitative study using the Consolidated Framework for Implementation Research (CFIR). [PDF]

open access: yesFront Public Health
Nagy E   +9 more
europepmc   +1 more source

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

open access: yesAdvanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song   +5 more
wiley   +1 more source

Positive psychological intervention to reduce HIV acquisition risk with men who use stimulants: protocol for a randomised controlled trial. [PDF]

open access: yesBMJ Open
Valentin OR   +13 more
europepmc   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

open access: yesAdvanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin   +3 more
wiley   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu   +4 more
wiley   +1 more source

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