Results 171 to 180 of about 257,990 (304)

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng   +10 more
wiley   +1 more source

Just4Us: Acceptability and Feasibility of a Woman-Focused Pre-exposure Prophylaxis (PrEP) Randomized Controlled Trial Intervention. [PDF]

open access: yesArch Sex Behav
Tieu HV   +7 more
europepmc   +1 more source

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1–NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Hongseo Choi   +22 more
wiley   +1 more source

Missed opportunities for PrEP among the partners of people newly initiated in HIV care in western Tanzania. [PDF]

open access: yesJ Acquir Immune Defic Syndr
Sheira LA   +11 more
europepmc   +1 more source

Prepping for Colonoscopy: Is Leisurely Holiday Prep Better Than Rushed Workday Prep?

open access: yesGastroenterology, 2011
Mohammed K. Mazumder   +4 more
openaire   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han   +11 more
wiley   +1 more source

Hybrid Semi‐Transparent Perovskite‐Photovoltaics and Concentrated Solar‐Thermal Harvesting Collectors

open access: yesAdvanced Science, EarlyView.
A hybrid semi‐transparent perovskite‐photovoltaic and concentrating solar‐thermal collector is developed to spectrally split sunlight for simultaneous electricity and heat generation. The design achieves thermal decoupling between the photovoltaic and thermal components, offering a promising route for efficient co‐harvesting of solar electricity and ...
Nada. A. Alati   +8 more
wiley   +1 more source

Trends of bacterial sexually transmitted infections with doxycycline post-exposure prophylaxis among people using pre-exposure prophylaxis for HIV. [PDF]

open access: yesSex Transm Infect
Chen YT   +18 more
europepmc   +1 more source

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