Results 151 to 160 of about 617,401 (307)

Barriers and Facilitators of Oral PrEP Uptake Against HIV Among Selected Priority Populations: A Global Perspective. [PDF]

Curr HIV/AIDS Rep
Ngwoke I, Adedire AM, Danladi NP, Eze CC, Dada OK, Okesanya OJ.   +5 more
europepmc   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Sustaining long-term pre-exposure prophylaxis use among international migrants

Population Medicine, 2023
Olalekan J. Okesanya, Emery Manirambona, Julian M.A. Buban, Don Eliseo Lucero-Prisno III   +3 more
doaj   +1 more source

Analysis of potential barriers for PrEP non-users among PrEP-eligible MSM in Germany. [PDF]

BMC Public Health
Waldorf H, Marcus U, Iannuzzi S, Albrecht S, Hoebel J, Gunsenheimer-Bartmeyer B, Bremer V, von Kleist M, Koppe U.   +8 more
europepmc   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Health Care Providers' Reported Barriers to Pre-Exposure Prophylaxis Initiation Among Cisgender Women. [PDF]

Health Educ Behav
Goldberg AJ, Flores RA, Desir A, Hickmon M, Ball T, Purtle J, Operario D, Golub SA, Price DM, Pellowski JA.   +9 more
europepmc   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis. [PDF]

PLoS Med
Tieosapjaroen W, Williams E, Johnson CC, Baptista Da Silva C, Barr-DiChiara M, Rodolph M, Ingold HL, Schmidt HA, Prochazka M, Msimanga B, Lastrucci C, Peralta H, Chitembo L, Andifasi P, Siegfried N, Landovitz RJ, Ong JJ.   +16 more
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Real-World Estimates of HIV Incidence From Sexual Health Clinic EMRs: Feasibility, Limitations, and Implications for Surveillance. [PDF]

J Acquir Immune Defic Syndr
Fischer Walker C, Lee MT, Chen PL, Ridgeway K, Johnson A, Doblecki-Lewis S, Castor D, Zucker J, Quigee D, Rifkin M, Gule D, Bouwer L, Mjenxane S, Janyam S, Somwaeng A, Putcharoen O, Avihingsanon A, Jomja P, Auchieng C, Russell E.   +19 more
europepmc   +1 more source