Results 131 to 140 of about 257,990 (304)

Modeling the Potential Impact of Scaling Up Event-Driven PrEP Among Gay, Bisexual, and Other Men Who Have Sex With Men. [PDF]

open access: yesJ Acquir Immune Defic Syndr
Chandra C   +4 more
europepmc   +1 more source

Barriers and facilitators to PrEP access, uptake and use in young people living in Queensland

open access: yes
In January 2021, the Australian Pharmaceutical Benefits Scheme expanded its eligibility for subsidised access to pre-exposure prophylaxis (PrEP) to people under 18-years. In Australia, there is a limited understanding of how intrapersonal, interpersonal,
Fowler, James A.   +9 more
core   +1 more source

An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach

open access: yesAdvanced Science, EarlyView.
An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang   +15 more
wiley   +1 more source

AIDS Behav [PDF]

open access: yes
Black and Hispanic/Latina transgender women are inequitably impacted by HIV; yet gaps in PrEP use exist. Among a sample of mostly Black and Hispanic/Latina transgender women in New York City, we aim to examine whether PrEP use was associated with gender ...

core  

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

open access: yesAdvanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan   +5 more
wiley   +1 more source

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

open access: yesAdvanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy