Results 121 to 130 of about 209,419 (263)

Implementación de la Profilaxis pre-exposición al VIH en Colombia

Interdisciplinary Journal of Epidemiology and Public Health, 2023
Hector Fabio Mueses-Marín, Ximena Galindo-Orrego, Beatriz Eugenia Alvarado-Llano, María Camila Bolívar-Rocha, Marcela Arrivillaga-Quintero, Pilar Camargo-Plazas, Julián Andrés Torres-Isasiga, Sheila Andrea Gómez-Peñalosa, Ernesto Martínez-Buitrago, Jorge Luis Martínez-Cajas   +9 more
doaj   +1 more source

Characterising individuals with newly diagnosed HIV before versus during the era of PrEP: a descriptive time-series analysis of data from a sexual health centre in Amsterdam, the Netherlands, 2015 to 2024. [PDF]

Euro Surveill
Boyd AC, Wijstma ES, de la Court F, van den Elshout MA, Yap K, van Benthem B, Hoornenborg E, Prins M.   +7 more
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Knowledge gaps and structural barriers to prescribing pre-exposure prophylaxis among healthcare providers in North Louisiana: A cross-sectional study. [PDF]

PLoS One
Smith DG, Castro C, Pichilingue-Reto P, Dean CG, Malek A, Espinoza LE.   +5 more
europepmc   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Where you live matters, but action is personal: insights from multilevel analysis of pre-exposure prophylaxis awareness, willingness, and use among men who have sex with men in China. [PDF]

Infect Dis Poverty
Gebregziabher NK, Zhang J, Shang Q, Wu Q, Cheng Z, Gong H, Yu M, Chen Z, Li C, Cui Z.   +9 more
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Campus healthcare workers' knowledge and views on injectable pre-exposure prophylaxis prior to rollout in South Africa: A qualitative study. [PDF]

PLOS Glob Public Health
Mbatha NN, Mpofana N, Gumede D.
europepmc   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

HIV self-testing for partners of postpartum women to facilitate HIV pre-exposure prophylaxis and antiretroviral therapy uptake: a protocol to adapt and pilot an intervention via a pilot randomised controlled trial in South Africa. [PDF]

BMJ Open
Psaros C, Beesham I, Mosery N, Aoun ZR, Bhardwaj A, Ndlovu L, Ntanzi N, Pratt MC, Chikovore J, Smit JA, Matthews LT.   +10 more
europepmc   +1 more source