Results 141 to 150 of about 257,990 (304)

Implementation of long-acting injectable PrEP at a Latine community organization: protocol for a mixed-methods, hybrid type 3 implementation-effectiveness study. [PDF]

BMJ Open
Cutshaw MK, Navarro I, Barfield R, Krajewski T, Kilpatrick KW, McKellar MS, Poteat T.   +6 more
europepmc   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Development and implementation of a pharmacy PrEP awareness-raising and referral pathway: acceptability and feasibility of a UK pilot. [PDF]

Sex Transm Infect
Harrison C, Harryman L, Stockwell S, Family H, Kesten JM, Denford S, Scott J, Sabin C, Copping J, Saunders J, Hamilton-Shaw R, Symonds N, Dick OB, Tarmey E, Horwood J.   +14 more
europepmc   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Women and Society in the Roman World. A Sourcebook of Inscriptions from the Roman West (E.A.) Hemelrijk Pp. xxii +345, ills, maps. Cambridge: Cambridge University Press, 2021. Cased, £99.99. ISBN: 978-1-107-14245-9.

The Journal of Classics Teaching, 2022
Lucy Benson
doaj   +1 more source

A scoping review of pre-exposure prophylaxis awareness, acceptability, uptake, adherence, and HIV-related risk behaviors among university students in South Africa. [PDF]

Front Public Health
Serebane MJ, Ramavhoya TI, Mutshatshi TE, Mokhwelepa LW.   +3 more
europepmc   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

PrEP access [PDF]

stsh_prep-ig2_v5Publication date from document properties.How Can I Start PrEP? -- How Do I Pay for PrEP?

core  

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

HIV pre-exposure prophylaxis in US prison settings: a model-based cost-effectiveness study. [PDF]

Lancet Reg Health Am
Park Y, Goldhaber-Fiebert JD, Cipriano LE.   +2 more
europepmc   +1 more source