Results 111 to 120 of about 209,419 (263)

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Warrior of Rome: Falling Sky (H.) Sidebottom, Pp. 376, map. London: Zaffre, 2022. Cased, £16.99. ISBN: 978-1838778019

The Journal of Classics Teaching
Brian J. Zawiski
doaj   +1 more source

Pre-Exposure Prophylaxis Adherence and HIV Self-Testing App Among Women in the South Bronx: 12-Month Usability, Acceptability, and Feasibility Study. [PDF]

JMIR Form Res
Wright CG, Chern TL, Abularrage TF, Franks J, Kahn A, Edwards S, Chellani HH, Redd R, Ying AW, Arumugam S, Stanciu R, Sia SK, Morrison EA, Justman JE.   +13 more
europepmc   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Diversity and the Study of Antiquity in Higher Education. Perspectives from North America and Europe (D.) Libatique and (F.) McHardy (edd.), Pp. viii + 144. Abingdon, Oxon: Routledge, 2023. Cased, £48.99. ISBN: 978-1-032-23512-7

The Journal of Classics Teaching
Brian J. Zawiski
doaj   +1 more source

Equity and Access in HIV Prevention: Addressing Global Disparities in PrEP Use Among Men Who Have Sex With Men Population. [PDF]

Am J Mens Health
Li S, Chan ASW.
europepmc   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Beauty and the Gods. A History from Homer to Plato (H.) Shakeshaft Pp. xxx + 498, b/w & colour ills. Princeton, NJ: Princeton University Press, 2025. Cased, £42, US$49.95. ISBN: 978-0-691-25020-5. https://press.princeton.edu/books/hardcover/9780691250205/beauty-and-the-gods

The Journal of Classics Teaching
Brian James Zawiski
doaj   +1 more source

Qualitative Insights on Client and Provider Barriers and Facilitators to Using a Novel Online HIV Pre- and Post-Exposure Delivery Model in Kenya. [PDF]

J Int AIDS Soc
Okello P, Thuo N, Roche SD, Saravis AL, Mwai D, Naik P, Kiptinness C, Kareithi T, Mugambi ML, Sharma M, Ngure K, Ortbald KF.   +11 more
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source