Results 91 to 100 of about 617,401 (307)
Advanced Science, EarlyView.DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang +11 more
wiley +1 more source
Evidence-Based Study of Medication Compliance Project in Hiv Prevention Using Pre-Exposure Prophylaxis (Prep) Antivirals for HIV-Negative Males [PDF]
, 2018 In 2012, emtricitabine/tenofovir was the only Food and Drug Administration-approved medication for pre-exposure prophylaxis (PrEP) used in human immunodeficiency virus (HIV) prevention.
Ho, Ming-Chun
core +1 more source
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source
Identify and Report Water Pollution: An Interpretive Guide to Surface Water Conditions of the New Hampshire Coastal Watershed, 2nd edition [PDF]
, 2007 This gude was designed to help people who work or recreate outdoors to interpret surface water conditions so that they would recognize a pollution incident and know how to report it.
New Hampshire Estuaries Project
core +4 more sources
Advanced Science, EarlyView.Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li +9 more
wiley +1 more source
Self-Prep Checklist Handout [PDF]
, 2018 Initiating & Sustaining Community-Academic Partnerships Erin Burke Brown, Ph.D., Director, ASPiRE This workshop presents “5 Simple Steps” for initiating and sustaining community-academic partnerships.
Brown, Erin B.
core +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Shellfish Tissue Monitoring in Piscataqua Region Estuaries 2014 [PDF]
, 2015 Originally conducted by the Gulf of Maine Council on the Marine Environment from 1993 to 2011, the Gulfwatch Program examined trends in the water quality of the Gulf of Maine by monitoring toxic contaminant concentrations in the tissues of shellfish ...
Wood, Matthew A.
core +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Testing of Great Bay Oysters for Two Protozoan Pathogens [PDF]
, 2006 Two protozoan pathogens, Haplosporidium nelsoni (MSX) and Perkinsus marinus(Dermo) are known to be present in Great Bay oysters. With funds provided by the New Hampshire Estuaries Project (NHEP), the Marine Fisheries Division of New Hampshire Fish and ...
Nelson, John I.
core +3 more sources